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1.
M. J. Robein M. C. de la Mare J. M. Dubrasquet S. Bonfils 《Inflammation research》1979,9(5-6):415-421
The perfused stomach in the anaesthetized rat was used to investigate the action of somatostatin on the gastric acid secretion stimulated by gastrin, histamine and carbamylcholine. Evidence is produced that somatostatin competitively inhibits gastrin-stimulated acid secretion whereas it inhibits carbamylcholine-stimulated acid secretion by a mechanism which is non-competitive in nature and it has no action on histamine-stimulated secretion.The model of the perfused stomach in the anaesthetized rat seems suitable to study the inhibition caused by drug on stimulated acid secretion. 相似文献
2.
Dominique?P?GermainEmail author Paul?Avan Augustin?Chassaing Pierre?Bonfils 《BMC medical genetics》2002,3(1):10
Background
Fabry disease (FD, OMIM 301500) is an X-linked inborn error of glycosphingolipid metabolism due to the deficient activity of alpha-galactosidase A, a lysosomal enzyme. While the progressive systemic deposition of uncleaved glycosphingolipids throughout the body is known to have protean clinical manifestations, few data are available regarding the cochlear involvement. 相似文献3.
J. Vatier C. Poitevin W. Riquet M. T. Vitre A. Olivier P. Martin S. Bonfils 《Inflammation research》1988,24(3-4):243-249
Measurements of acid and pepsin secretions and of histamine release in response to food alone or in combination with graded doses of antramine (AH), a molecular form of histamine isolated from antral mucosa, with or without somatostatin were performed simultaneously in dogs equipped with a denervated pouch.AH restored somatostatin-inhibited acid and pepsin secretions but with different intensities in regard to the different inhibitory levels induced by somatostatin.AH competitively antagonized somatostatin (1 g/kg/h) inhibition of acid cecretion, but when stronger levels of inhibition were achieved, AH restored weakly acid secretion. Recovery of pepsin secretion occured through a competitive mechanism between AH and somatostatin (1 and 2 g/kg/h). There was a close relationship between the secretory outputs and the integrated histamine responses; the slopes of the regression lines might be considered as reflecting the stimulatory activity of blood histamine on secreting cells. For acid secretion, this activity is similar in control and somatostatin (1 g/kg/h) tests, while for pepsin secretion it is identical in control and 1 or 2 g/kg/h somatostatin tests.One can speculate that the suppression of the somatostatin inhibitory effects by antramine, within the limits of physiological conditions, results from a competitive mechanism. 相似文献
4.
Frdric Bonfils Jean-Marc Fabre Louis Giral Claude Montginoul Aumduth Mungroo Ren Sagnes Franois Schu 《Macromolecular chemistry and physics.》1989,190(11):2759-2771
In order to study the influence of the nature of the moiety bearing a tetrathiafulvalenyl group in the polymers upon the microlithographic properties of resists, poly(p-chloromethylstyrene)s and poly(styrene-co-p-chloromethylstyrene)s containing the 4-tetrathiafulvalenylphenoxymethyl group with a variety of controlled molecular weights and molecular weight distributions were studied. The copolymers were all prepared by reaction of poly(4-vinylbenzyl chloride) with potassium 4-tetrathiafulvalenylphenolate ( 3 ). Without exception, the resulting poly[p-chloromethylstyrene-co-p-(tetrathiafulvalenylphenoxymethyl)styrene]s are highly insoluble. However, by reaction of potassium 4-tetrathiafulvalenylphenolate with poly(styrene-co-p-chloromethylstyrene) soluble copolymers could be prepared. 相似文献
5.
L Siproudhis J Vilotte S Bonfils M Mignon 《Gastroentérologie clinique et biologique》1991,15(4):315-321
Endoscopic information was obtained for 52 patients with ulcerative proctitis (23 F, 29 H) seen during a ten-year period. The median follow-up was 68 +/- 8 months. During the first referral period (38 patients experienced a first attack), endoscopic particularities were available: inflammation involved the anal mucosa above the dental line (n = 16), the whole circumference of rectal mucosa (n = 19) or the anterior wall exclusively (n = 33). The upper limit was 12.2 +/- 0.6 cm from the anal verge. Inflammatory lesions were higher in circumferencial conditions, when patients were older (late onset disease) but sex and ethnic state did not influence results of endoscopic presentation. Exulcerations or superficial ulcers were visualized in 16 and spontaneous bleeding in 43. Forty-five patients achieved clinical accuracy after 9.4 +/- 1 ms, but 32 only a complete endoscopic remission. Mean number of relapses was 3.6 +/- 0.4; 13 patients experienced a single attack. During relapses, inflammation was stable in 11 of 38 patients. Extension to the rectum in rectosigmoid junction, and sigmoid and above by 6, 14, and 7 patients respectively. After 5 years follow-up, the cumulative risk of further extension was 37 percent and 13 percent, respectively. Low abdominal pain, an family history of ulcerative colitis, and high inflammatory lesions at referral were significantly associated with a higher risk of extension. Cancer did not occur and not surgery was necessary during the follow-up. Idiopathic proctitis is perhaps at the "benign end" of the spectrum of ulcerative colitis. Nevertheless, its endoscopic particularities should be noticed.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
6.
7.
Long acting somatostatin treatment of paraneoplastic Cushing's syndrome in a case of Zollinger-Ellison syndrome.
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Cushing's syndrome, caused by ectopic ACTH production during Zollinger-Ellison syndrome, raises difficult therapeutic problems. We report a case of clinical and biological efficacy of long acting somatostatin (SMS) in this condition. In a short term study with 200 micrograms SMS bid, symptoms of hypercorticism disappeared while cortisol and ACTH serum concentrations fell below the normal values. Longterm treatment was instituted with 50 micrograms SMS bid. Excellent clinical efficacy as well as normal cortisol and ACTH serum concentrations were maintained during the nine month follow up. Lipotrophic hormone (LPH) serum concentration remained raised. No decrease in size of hepatic metastases was observed. Long acting somatostatin analogues may be useful in endocrine paraneoplastic syndromes. 相似文献
8.
Otte Günther Dinkler Henrich Schumacher Dietrich W. Fischer Rlebeling Eckstein Rosenhagen Klose Bonfils 《Journal of molecular medicine (Berlin, Germany)》1934,13(11):422-426
Ohne Zusammenfassung 相似文献
9.
Eisner-Behrend Grassheim Lewy Zinn Esch Taterka Magnus-Alsleben Koenigsfeld Edens Oppenheimer Bernhardt Sperling Mendel Lenneberg Griesbach Schübel Erich Langer Buschke Sen Erich Langer Finkenrath Weigert Otte Valentin Michaelis Goldstein Bonfils Sacher 《Journal of molecular medicine (Berlin, Germany)》1932,11(45):1886-1890
Ohne Zusammenfassung 相似文献
10.
Fuchs Schübel Oppenheimer Griesbach Erich Langer Finkenrath Eisner-Behrend Jaffé Simon Michaelis Mendel Goldstein Mendel Bonfils Langenbeck Esch 《Journal of molecular medicine (Berlin, Germany)》1932,11(30):1277-1282
Ohne Zusammenfassung 相似文献