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1.
I A Bochkov O D Trofimova O S Darbeeva R S Cherkasskaia M S Shevchuk 《Laboratornoe delo》1989,(6):43-47
Formulae for the calculation of the count of microorganisms isolated from natural bacterial biocenoses of a child's body have been derived. The authors suggest a variant of simplified drip method for the computation of microorganism colonies in solid media. The described method helps cut down the nutrient media consumption at least 3-fold and is time-saving. 相似文献
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I. A. Zavalishin N. P. Bochkov Z. A. Suslina M. N. Zakharova V. Z. Tarantul B. S. Naroditskiy N. A. Suponeva S. N. Illarioshkin M. M. Shmarov D. Y. Logunov I. L. Tutyhina L. V. Verkhovskaya E. S. Sedova A. V. Vasiliev L. V. Brylev A. L. Ginzburg 《Bulletin of experimental biology and medicine》2008,145(4):483-486
Two-year experiments were performed to evaluate the neurotrophic effect of hypoxia-inducible factors (vascular endothelial
growth factor and angiogenin) expressed in recombinant human adenoviruses in amyotrophic lateral sclerosis. Randomized placebo-controlled
trial demonstrated safety and good tolerability of the recombinant antiviral drugs. The life span of patients under conditions
of hypoxia increased after treatment with the test drug, which was probably related to improved resistance of motoneurons.
The presence of virus-neutralizing antibodies decreases the effectiveness of adenoviral vectors, which necessitates differential
approach to the selection of patients and continuous monitoring of gene therapy.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 4, pp. 467–470, April, 2008 相似文献
4.
Andre V. Bochkov Marcela Lareschi Mauricio Barreto 《Acta parasitologica / Witold Stefański Institute of Parasitology, Warszawa, Poland》2014,59(4):586-595
Six fur-mite species of the genus Prolistrophorus Fain, 1970 (Acariformes: Listrophoridae) were recorded from Central and South American rodents of the subfamily Sigmodontinae (Rodentia: Cricetidae). Among them, Prolistrophorus (Aprolistrophorus) parabidentatus sp. nov. from Akodon azarae from Argentina and Prolistrophorus (Aprolistrophorus) tylomys sp. nov. from Tylomys nudicaudus from Guatemala are described as new for science. New hosts are recorded for the following species: Prolistrophorus (Prolistrophorus) grassii (Radford, 1954) from Zygodontomys brevicauda from Colombia, P. (P.) frontalis (Hirst, 1921) from Oligoryzomys sp. from Argentina, P. (P.) argentinus (Hirst, 1921) from Melanomys caliginosus, Akodon affinis from Colombia and Scapteromys aquaticus from Argentina, Prolistrophorus (Beprolistrophorus) hirstianus Fain, 1973 from Scapteromys aquaticus from Argentina. 相似文献
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Meshkov AN Stambol'skiĭ DV Krapivner SR Bochkov VN Kukharchuk VV Malyshev PP 《Kardiologiia》2004,44(9):58-61
Low density lipoprotein receptor (LDLR) gene mutations cause familial hypercholesterolemia which is associated with elevated risk of ischemic heart disease. AIM: To define LDLR gene mutations in unrelated patients with heterozygous familial hypercholesterolemia in Russia. METHODS: PCR- single-strand conformation polymorphism analysis, automated DNA sequencing, and test for the presence of the apolipoprotein (apo) B-3500 mutation known to induce hereditary defect in apo-B-100. RESULTS: We found 6 novel mutations of LDLR gene designated E8X, 230insG, 671_679dupGACAAATCT, W422R, D461Y, and V698L. We also identified three missense mutations - C139G, E207K and R395W, which were previously described in FH patients from western populations. None of the studied persons had apo-B-3500 mutation. CONCLUSION: These findings broaden knowledge on mutations responsible for development of familial hypercholesterolemia and confirm molecular heterogeneity of this disease in Russia. 相似文献
7.
G Stübiger E Aldover-Macasaet W Bicker G Sobal A Willfort-Ehringer K Pock V Bochkov K Widhalm O Belgacem 《Atherosclerosis》2012,224(1):177-186
ObjectivesPhospholipids (PLs) are increasingly recognized as key molecules with potential diagnostic value in acute inflammation, CVD and atherosclerosis. We introduce a pioneer mass spectrometry (MS)-based approach aiming to investigate the relationship of specific plasma PL-subsets with atherogenic blood parameters in young patients with familial hyperlipidemia representing high-CVD-risk groups.MethodsPlasma of carefully phenotyped FH and FCH patients as well as normolipidemic subjects (age 13 ± 5 years, n = 20) was used. Clinical parameters were assessed using standard laboratory techniques and lipids were subjected to a direct targeted monitoring using LC-ESI-SRM- and MALDI-QIT-TOF-MS/MS, respectively. Statistical analysis was performed to evaluate correlations between PL data and the clinical parameters.ResultsMost characteristically significant differences of SM/PC and PC/LPC ratios and positive correlations between SM vs. LDL-C (r = 0.946; p = 0.004) and LPC vs. VLDL-C (r = 0.669; p = 0.218) were observed in FH in contrast to the other study groups. OxPC levels were found in the range of ~2–20 μmol/L with predominance of short-chain aldehydic species (e.g. SOVPC). A positive correlation of OxPCs with IMT (r = 0.952; p = 0.052) and HDL-C (r = 0.893; p = 0.016) but negative correlation with OxLDL (r = ?0.910; p = 0.096) was observed.ConclusionsOur study was a first attempt to use a MALDI-QIT-TOF-MS/MS based clinical lipidomics approach to investigate atherogenic dyslipidemia in young patients with familial hyperlipidemia. This technique represents a promising platform for clinical screening of lipid biomarkers in the future. 相似文献
8.
Riitta Turunen Tuomas Jartti Yury A. Bochkov James E. Gern Tytti Vuorinen 《Journal of medical virology》2016,88(12):2059-2068
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N. P. Bochkov V. A. Nikitina E. S. Voronina N. P. Kuleshov 《Bulletin of experimental biology and medicine》2009,148(4):677-683
A combination of karyotyping and aneuploidy analysis by interphase fluorescent in situ hybridization is a sensitive method for evaluation of genetic stability of stem cell cultures. The methodology and specific
features of preparing and analyzing the cytogenetic preparations are described as exemplified by human multipotent mesenchymal
stromal cells. 相似文献