Naphthalimido derivatives as antifolate thymidylate synthase inhibitors

A new series of N-(substituted)benzyl-1,8-naphthalimides 4, structurally related to the previously reported thymidylate synthase (TS) inhibitor naphthaleins 3, were synthesized and compounds tested for their inhibition of several species of TS. Moreover, their in vitro cytotoxicity together with antimycotic and antibacterial properties were assayed. While no activity was detected in the antibacterial tests, the m-nitro (4ae) and the p-nitro (4af) derivatives were found able to partially inhibit TS at low micromolar concentrations. Introduction of nitro or (substituted)-amino groups in position 4 of the naphthalic ring always led to less active compounds.     

Critical ovarian hyperstimulation syndrome in a coasted in-vitro fertilization patient

We report an instance of critical ovarian hyperstimulation syndrome in a highly responsive in-vitro fertilization patient despite the preventive measure of a 4 day 'coast' interval during which no gonadotrophins were administered while gonadotrophin-releasing hormone agonist therapy continued until serum oestradiol concentrations fell below 3000 pg/ml.      

Collagen in desmoids (an immunomorphological study)

The results of immunomorphological analysis of 4 collagen types in desmoids of different localization and behaviour are presented. Biopsies of 12 nodes (6 cases of abdominal and 6 cases of extraabdominal localization) were studied. Two groups of desmoids were defined depending on the character of different collagen types distribution. Desmoids of the first group were characterized by a high content of type I and III collagen, both types being found at approximately equal proportions. Clinically predominant abdominal localization and primary character of processes were typical for this group. Collagen of type III clearly predominated in the desmoids of the second group; extraabdominal localization, recurrences, and a young age of patients were characteristic features of this group.