全文获取类型
收费全文 | 2204篇 |
免费 | 150篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 103篇 |
妇产科学 | 56篇 |
基础医学 | 313篇 |
口腔科学 | 57篇 |
临床医学 | 236篇 |
内科学 | 346篇 |
皮肤病学 | 50篇 |
神经病学 | 246篇 |
特种医学 | 90篇 |
外科学 | 341篇 |
综合类 | 21篇 |
一般理论 | 1篇 |
预防医学 | 155篇 |
眼科学 | 23篇 |
药学 | 165篇 |
肿瘤学 | 144篇 |
出版年
2023年 | 23篇 |
2022年 | 19篇 |
2021年 | 37篇 |
2020年 | 27篇 |
2019年 | 48篇 |
2018年 | 50篇 |
2017年 | 45篇 |
2016年 | 58篇 |
2015年 | 59篇 |
2014年 | 58篇 |
2013年 | 95篇 |
2012年 | 127篇 |
2011年 | 148篇 |
2010年 | 68篇 |
2009年 | 59篇 |
2008年 | 108篇 |
2007年 | 106篇 |
2006年 | 80篇 |
2005年 | 91篇 |
2004年 | 93篇 |
2003年 | 86篇 |
2002年 | 85篇 |
2001年 | 40篇 |
2000年 | 33篇 |
1999年 | 36篇 |
1998年 | 22篇 |
1997年 | 23篇 |
1996年 | 22篇 |
1995年 | 13篇 |
1994年 | 22篇 |
1993年 | 23篇 |
1992年 | 43篇 |
1991年 | 29篇 |
1990年 | 33篇 |
1989年 | 28篇 |
1988年 | 14篇 |
1987年 | 22篇 |
1986年 | 22篇 |
1985年 | 28篇 |
1984年 | 25篇 |
1983年 | 38篇 |
1982年 | 23篇 |
1981年 | 13篇 |
1979年 | 29篇 |
1978年 | 14篇 |
1977年 | 19篇 |
1976年 | 12篇 |
1974年 | 12篇 |
1973年 | 12篇 |
1966年 | 11篇 |
排序方式: 共有2362条查询结果,搜索用时 15 毫秒
1.
Registry of the International Society for Heart and Lung Transplantation: twenty-second official adult lung and heart-lung transplant report--2005. 总被引:13,自引:0,他引:13
2.
Flemming M. Nilsson Birgitte L. Hansen Christian Büchel Wagner F. Gattaz Jes Gerlach 《European archives of psychiatry and clinical neuroscience》1996,246(2):71-77
Digital movment analysis (DMA) is a new instrumental approach to assessing oral tardive dyskinesia (TD) by means of digital image processing of a video signal, tracking five paper dots placed around the patient's mouth. A total of 40 schizophrenic patients, 30 with and 10 without TD, were examined twice (with a 3-month interval) with this new device. The patients were further examined with two TD rating scales: the St. Hans Rating Scale for extrapyramidal syndromes (SHRS) and the Abnormal Involuntary Movement Scale (AIMS).The schizophrenic patients accepted the instrumental assessment without any anxiety or resistance. The internal relibility of the apparatus was high, with correlation coefficients of 0.80–0.99. The DMA TD values correlated with the SHRS and AIMS scores with correlation coefficients of 0.48–0.73 indicating an acceptable, although not strong, concurrent validity. Fluctuations occurred from the first to the second examination independent of medication. For these fluctuations no correlation was found between DMA values and rating scores. Finally, the DMA device was able to detect perioral tremor as a sign of parkinsonism.It has been concluded that DMA is a useful supplement to classical TD rating, although further validity evaluation is warranted. 相似文献
3.
BACKGROUND: Recalcitrant gingival erythematous lichen planus/lichenoid lesions comprise a considerable therapeutic problem. The objective of this study was to evaluate the therapeutic effect of grafting keratinized oral palatal mucosa to the sites of gingival lichen. METHODS: In 12 patients 20 grafts were transplanted to buccal gingival lesions. Mean age of the patients was 59.8 +/- 7.1 years (range 46-71 years). The mean observation time was 32 +/- 32.7 months (range 5-97 months). RESULTS: On a 4-point clinical grade scale (0-3), 12 (60%) transplants showed complete healing grade 3, six (30%) grade 2 and two (10%) grade 1. CONCLUSIONS: Using oral mucosal grafts from the palatal mucosa for the treatment of recalcitrant erythematous gingival lichen planus/lichenoid lesions seems to be a promising treatment modality. 相似文献
4.
5.
The Registry of the International Society for Heart and Lung Transplantation: twenty-first official adult lung and heart-lung transplant report--2004. 总被引:17,自引:0,他引:17
6.
The question whether the benzodiazepine receptor site in astrocytes or in neurons might be identical to the adenosine uptake site was studied by determining pharmacological profiles, inhibition types, and the effects of benzodiazepine antagonsts in primary cultures of either astrocytes or neurons. Fourteen different benzodiazepines and five different adenosine uptake inhibitors displaced [3H] diazepam and inhibited adenosine uptake in both astrocytes and neurons. However, the rank orders (determined as IC50 values) with which these two parameters were affected were profoundly different, indicating dissimilarities between these two sites. For several of the compounds a difference in inhibition type (competitive vs. noncompetitive) was observed between the benzodiazepine-binding site and the adenosine uptake site in astrocytes and/or neurons, which further corroborated the conclusion of a difference between the benzodiazepine-binding site and the adenosine uptake site. Finally, the neuronal benzodiazepine antagonists RO 15-1788 and CGS-8216 and the astrocytic benzodiazepine antagonist PK 11195, which reverse the action of benzodiazepines, were not able to reverse inhibition of adenosine uptake by diazepam but exerted an inhibitory effect of their own. 相似文献
7.
Dual blockade of the renin-angiotensin system in type 1 patients with diabetic nephropathy. 总被引:7,自引:0,他引:7
Peter Jacobsen Steen Andersen Kasper Rossing Birgitte V Hansen Hans-Henrik Parving 《Nephrology, dialysis, transplantation》2002,17(6):1019-1024
BACKGROUND: Albuminuria and hypertension are predictors of poor renal and cardiovascular outcome in patients with diabetes. Approximately 30% of type 1 patients with diabetic nephropathy (DN) have albuminuria >1 g/day, and blood pressure >135 and/or >85 mmHg despite antihypertensive therapy with recommended doses of ACE inhibitor (ACEI) and diuretics. We tested the effect of dual blockade of the renin-angiotensin system (RAS) in these patients. METHODS: We performed a randomised double blind crossover trial with 2 months treatment with Irbesartan 300 mg o.d. and placebo added on top of previous antihypertensive treatment. We included 21 type 1 patients with DN responding insufficiently to ACEI and diuretics, as defined above. At the end of each treatment period, albuminuria, 24-h blood pressure and glomerular filtration rate (GFR) were measured. RESULTS: Addition of 300 mg Irbesartan to the patients' usual antihypertensive therapy induced a mean reduction in albuminuria of 37% (95% CI 20-49, P<0.001); from 1574 mg/24 h (95% CI 1162-2132) to 996 mg/24 h (95% CI 699-1419), a reduction in 24-h blood pressure of 8 mmHg systolic (95% CI -2 to 18) and 5 mmHg diastolic (95% CI 1-9) (P=0.11 and 0.01, respectively) (from placebo, mean (SE) 146 (4)/80 (2) mmHg). GFR remained unchanged. Serum potassium increased (mean 4.3 to 4.6 mmol/l, P=0.02). Intervention to reduce serum potassium was needed in two patients with GFR <35 ml/min/1.73 m(2). Otherwise the dual blockade with Irbesartan was safe and well tolerated. CONCLUSIONS: Dual blockade of the RAS may offer additional renal and cardiovascular protection in type 1 patients with DN responding insufficiently to conventional antihypertensive therapy, including recommended doses of ACEI and diuretics. 相似文献
8.
Computed tomography (CT) after abdominoperineal (AP) resection for rectal carcinoma is a routine procedure for the detection of recurrent tumor and distal metastases. We reviewed sequential CT scans after AP resection in 52 patients in order to see whether the urinary tract as a neighboring organ is involved in recurrent malignancy. Bladder displacement in itself was not associated with hydronephrosis. Such hydronephrosis developed, however, in 14 patients--13 with a presacral mass, and one with retroperitoneal lymphadenopathy. In 23 of the 52 patients a presacral mass appeared, either fibrosis, infection, or recurrence. Severe hydronephrosis was found only with malignancy. We suggest that marked hydronephrosis associated with a presacral mass after AP resection is an indirect sign of malignancy. 相似文献
9.
Birgitte Lidegaard Frederiksen Merete Osler Henrik Harling Steen Ladelund Torben Jørgensen 《Social science & medicine (1982)》2009
This paper investigates the association between individually measured socioeconomic status (SES) and all-cause survival in colorectal cancer patients, and explores whether factors related to the patient, the disease, or the surgical treatment mediate the observed social gradient. 相似文献
10.
We are presenting an investigation of 47 cases treated with Kirschner wire fixation using drill wires for distal radius fractures. The average study period was 18 months after the fixation (13-25 months). Using Sarmiento's ratings we obtained the following results: 21 patients were rated as excellent, 19 as good, 6 as fair and 1 as poor. In contrast to a good reduction with a stepless joint surface, the initial fracture form and displacement does not influence the functional end results. 相似文献