全文获取类型
收费全文 | 509篇 |
免费 | 14篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 14篇 |
妇产科学 | 6篇 |
基础医学 | 63篇 |
口腔科学 | 3篇 |
临床医学 | 47篇 |
内科学 | 88篇 |
皮肤病学 | 51篇 |
神经病学 | 45篇 |
特种医学 | 8篇 |
外科学 | 86篇 |
综合类 | 16篇 |
一般理论 | 1篇 |
预防医学 | 36篇 |
眼科学 | 5篇 |
药学 | 22篇 |
肿瘤学 | 13篇 |
出版年
2022年 | 3篇 |
2019年 | 4篇 |
2018年 | 5篇 |
2017年 | 6篇 |
2016年 | 6篇 |
2014年 | 3篇 |
2013年 | 12篇 |
2012年 | 13篇 |
2011年 | 10篇 |
2010年 | 11篇 |
2009年 | 9篇 |
2008年 | 12篇 |
2007年 | 12篇 |
2006年 | 25篇 |
2005年 | 38篇 |
2004年 | 21篇 |
2003年 | 26篇 |
2002年 | 38篇 |
2001年 | 19篇 |
2000年 | 20篇 |
1999年 | 19篇 |
1998年 | 8篇 |
1996年 | 8篇 |
1994年 | 5篇 |
1992年 | 10篇 |
1990年 | 13篇 |
1989年 | 11篇 |
1988年 | 4篇 |
1987年 | 9篇 |
1986年 | 15篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 8篇 |
1982年 | 10篇 |
1980年 | 7篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1977年 | 4篇 |
1976年 | 7篇 |
1975年 | 5篇 |
1974年 | 10篇 |
1973年 | 4篇 |
1972年 | 7篇 |
1971年 | 6篇 |
1970年 | 5篇 |
1969年 | 3篇 |
1968年 | 7篇 |
1967年 | 4篇 |
1966年 | 3篇 |
1929年 | 3篇 |
排序方式: 共有525条查询结果,搜索用时 46 毫秒
1.
Flexible Sigmoidoscopy Screening in an Industrial Setting 总被引:1,自引:0,他引:1
Benjamin Krevsky M.D. M.P.H. F.A.C.G. Tomasz Niewiarowski M.D. Rita League R.N. Harold Herman M.D. Lisa Matz Robert S. Fisher M.D. F.A.C.G. 《The American journal of gastroenterology》1992,87(12):1759-1762
Little is known about the yield of colorectal cancer screening programs in an industrial setting. We therefore established a flexible sigmoidoscopy screening program at a chemical manufacturing plant and offered testing to all employees over the age of 40. After a Fleet enema preparation had been administered, a digital rectal examination and sigmoidoscopy were performed on each volunteer worker in the medical office of the plant. The plant had an average census of about 650 workers; 202 were screened during a 2-yr period. The mean (+/- SEM) age of participants was 52 +/- 0.4. Sixty-four employees had polyps (31.7%); data on follow-up colonoscopy were available in 69%. Colonoscopy revealed adenomatous polyps in 23 workers (53.5%), hyperplastic polyps in 10 (23%), and no evidence of neoplasia in 10 (23%). Seven workers did not arrange for follow-up colonoscopy and 12 individuals could not be contacted. No cancers were detected. In the 40- to 50-yr age group, polyps were detected in 19.5% of employees (25% adenomatous). Incidental findings were common, and included prostatic nodules, hemorrhoids, diverticulosis, and proctitis, among others. We conclude that screening sigmoidoscopy can be conveniently and economically performed at the workplace, with a high yield and good worker acceptance. The high yield suggests a possible association between polyp formation and work in a chemical plant. The finding of adenomatous polyps in the younger patients suggests that the threshold for flexible sigmoidoscopy at age 50 needs to be reassessed. 相似文献
2.
Heightened Expression of the Cytotoxicity Receptor NKG2D Correlates with Acute and Chronic Nephropathy After Kidney Transplantation 总被引:4,自引:0,他引:4
3.
W. W. Grody R. J. Chang N. M. Panagiotis D. Matz S. D. Cederbaum 《Journal of inherited metabolic disease》1994,17(5):566-574
Summary We report two female patients, one with a known inborn error of ureagenesis and the other of unknown cause, in whom recurrent, transient episodes of severe hyperammonaemia increased in frequency and severity with sexual maturity and parturition. Both responded to ovarian steroids administered continuously to suppress ovulation and menstruation, and ultimately to simple hysterectomy. These studies suggest a new therapeutic approach to defective ureagenesis in female patients and a relationship between ammonia production or disposal and the menstrual cycle. 相似文献
4.
Matz PE Foster GD Faith MS Wadden TA 《Journal of consulting and clinical psychology》2002,70(4):1040-1044
Predictors of body image dissatisfaction (BID) among obese people are poorly understood. In 79 obese women seeking weight reduction, associations with BID of self-esteem, youth teasing, adult teasing, and internalization of sociocultural appearance standards (ISAS) were studied. Analyses revealed that only self-esteem, adult teasing, and ISAS predicted BID. Results highlight the importance of adulthood self-esteem and interpersonal-cultural context--rather than childhood experiences--in predicting adulthood BID. 相似文献
5.
Bernd Kupfer Torsten Ruf Bertfried Matz Jacob Nattermann Ulrich Spengler Jürgen K Rockstroh Hans H Brackmann Johannes Blümel Michael Tacke Rolf Kaiser 《Journal of clinical virology》2005,34(1):42-47
BACKGROUND: Until the mandatory introduction of viral inactivation techniques of blood plasma products in the early 1980s many recipients of these products were infected with various viral pathogens. OBJECTIVES: To determine the rate of transmission of GB virus C/hepatitis G virus (GBV-C/HGV) HCV, and HIV through non-virus-inactivated clotting factor concentrates in hemophiliacs, as well as the relation between amount of administered clotting factor and risk for GBV-C/HGV infection. STUDY DESIGN: In this cross-sectional study, we determined retrospectively the rates of infection markers for GBV-C/HGV, HCV, and HIV in a German cohort of hemophiliacs treated with documented amounts of non-virus-inactivated clotting factor concentrates (group A) and in a second group of hemophiliacs who were treated exclusively with virus-inactivated clotting factor (group B). The presence of anti-virus antibodies was determined by ELISA. Viral RNA was detected by RT-PCR. Markers for viral infections were compared to amounts of administered non-virus-inactivated clotting factor. RESULTS: Among hemophiliacs treated with documented amounts of non-virus-inactivated clotting factor the prevalence for GBV-C/HGV, HCV, and HIV was 40.3%, 98.6%, and 56.3%, respectively. In contrast to HIV, the rate of GBV-C/HGV infections did not increase with increasing amounts of consumed non-inactivated clotting factor. Even in the subgroup of heavily treated hemophiliacs the rate of GBV-C/HGV infection markers did not exceed 45%. CONCLUSIONS: The amount of non-virus-inactivated clotting factor is not predictive for the risk of GBV-C/HGV infection in hemophiliacs. Despite repeated parenteral exposure more than 55% of hemophiliacs were not infected with GBV-C/HGV. Our findings indicate a high frequency of host factors preventing parenteral transmission of GBV-C/HGV. 相似文献
6.
D. Scott Kreiner Paul Matz Christopher M. Bono Charles H. Cho John E. Easa Gary Ghiselli Zoher Ghogawala Charles A. Reitman Daniel K. Resnick William C. Watters Thiru M. Annaswamy Jamie Baisden Walter S. Bartynski Shay Bess Randall P. Brewer R. Carter Cassidy David S. Cheng Sean D. Christie Amy M. Yahiro 《The spine journal》2021,21(4):726-727
7.
8.
Georg Bauer Susanne Kahl Iva Singh Sawhney Petra Hfler Ralph Gerspach Bertfried Matz 《International journal of cancer. Journal international du cancer》1992,51(5):754-760
Studies on the mechanisms of transformation of mammalian cells by herpes simplex virus (HSV) in vitro have been prevented so far by the extremely low transformation frequencies obtained in monolayer culture. Here we present a transformation system that relies on the direct seeding in soft agar of infected single cells, thus avoiding negative interactions between normal and transformed cells. We took advantage of HSV-I temperature-sensitive mutants at the UL9 locus, which codes for a DNA-binding protein necessary for viral DNA replication. At the non-permissive temperature, viral DNA synthesis and late gene expression are prevented. Viral gene expression is restricted to immediate early and early genes. Induction of transformation was highly efficient in our one-step transformation system. It depended on intact viral particles and viral DNA. Immediate early and/or early viral gene expression was sufficient to induce transformation. Colonies were stably transformed and did not show any rescue of viable virus after temperature downshift and co-cultivation with susceptible cells. Transformed cells maintained the transformed state in the absence of viral DNA. Our data therefore support the "hit-and-run" hypothesis for the transforming effect of HSV. 相似文献
9.
Free radical pathways in CNS injury 总被引:66,自引:0,他引:66
Free radicals are highly reactive molecules implicated in the pathology of traumatic brain injury and cerebral ischemia, through a mechanism known as oxidative stress. After brain injury, reactive oxygen and reactive nitrogen species may be generated through several different cellular pathways, including calcium activation of phospholipases, nitric oxide synthase, xanthine oxidase, the Fenton and Haber-Weiss reactions, by inflammatory cells. If cellular defense systems are weakened, increased production of free radicals will lead to oxidation of lipids, proteins, and nucleic acids, which may alter cellular function in a critical way. The study of each of these pathways may be complex and laborious since free radicals are extremely short-lived. Recently, genetic manipulation of wild-type animals has yielded species that over- or under-express genes such as, copper-zinc superoxide dismutase, manganese superoxide dismutase, nitric oxide synthase, and the Bcl-2 protein. The introduction of the species has improved the understanding of oxidative stress. We conclude here that substantial experimental data links oxidative stress with other pathogenic mechanisms such as excitotoxicity, calcium overload, mitochondrial cytochrome c release, caspase activation, and apoptosis in central nervous system (CNS) trauma and ischemia, and that utilization of genetically manipulated animals offers a unique possibility to elucidate the role of free radicals in CNS injury in a molecular fashion. 相似文献
10.
Localization of a myosin heavy chain-like polypeptide to Drosophila nuclear pore complexes. 总被引:3,自引:0,他引:3
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
M Berrios P A Fisher E C Matz 《Proceedings of the National Academy of Sciences of the United States of America》1991,88(1):219-223
Antibodies previously used for immunofluorescence localization of a myosin heavy chain-like polypeptide to the nuclear envelope in higher eukaryotic cells crossreact with both muscle and nonmuscle isoforms of Drosophila myosin heavy chain. Analyses of Drosophila tissue culture cells and premyogenic embryos suggest that it is the nonmuscle isoform that is associated with the nuclear envelope. Further immunofluorescence and immunoelectron microscopy indicate that this polypeptide is associated with nuclear pore complexes. These data support the hypothesis put forward previously that myosin or myosin-like molecules play a role in pore complex architecture. 相似文献