全文获取类型
收费全文 | 2250篇 |
免费 | 347篇 |
国内免费 | 42篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 109篇 |
妇产科学 | 19篇 |
基础医学 | 190篇 |
口腔科学 | 28篇 |
临床医学 | 326篇 |
内科学 | 671篇 |
皮肤病学 | 61篇 |
神经病学 | 212篇 |
特种医学 | 286篇 |
外科学 | 407篇 |
综合类 | 36篇 |
预防医学 | 69篇 |
眼科学 | 25篇 |
药学 | 63篇 |
中国医学 | 1篇 |
肿瘤学 | 112篇 |
出版年
2023年 | 56篇 |
2022年 | 13篇 |
2021年 | 34篇 |
2020年 | 101篇 |
2019年 | 21篇 |
2018年 | 100篇 |
2017年 | 80篇 |
2016年 | 74篇 |
2015年 | 74篇 |
2014年 | 116篇 |
2013年 | 129篇 |
2012年 | 84篇 |
2011年 | 78篇 |
2010年 | 89篇 |
2009年 | 124篇 |
2008年 | 73篇 |
2007年 | 65篇 |
2006年 | 66篇 |
2005年 | 68篇 |
2004年 | 47篇 |
2003年 | 30篇 |
2002年 | 33篇 |
2001年 | 54篇 |
2000年 | 37篇 |
1999年 | 43篇 |
1998年 | 88篇 |
1997年 | 97篇 |
1996年 | 81篇 |
1995年 | 69篇 |
1994年 | 55篇 |
1993年 | 52篇 |
1992年 | 36篇 |
1991年 | 19篇 |
1990年 | 34篇 |
1989年 | 57篇 |
1988年 | 46篇 |
1987年 | 30篇 |
1986年 | 27篇 |
1985年 | 26篇 |
1984年 | 22篇 |
1983年 | 13篇 |
1982年 | 19篇 |
1981年 | 18篇 |
1980年 | 20篇 |
1979年 | 17篇 |
1978年 | 10篇 |
1977年 | 16篇 |
1976年 | 11篇 |
1975年 | 8篇 |
1971年 | 8篇 |
排序方式: 共有2639条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
The authors reports their experience of 5 cases of intra- and peri-aqueductal tumors. With the exception of 1 case, a subependymoma of the aqueduct discovered at autopsy in a 77 year old woman, the 4 other patients (2 females and 2 males) are relatively young (respectively 14, 23, 14 and 26) at the time when they presented with signs of chronically raised intracranial pressure due to a triventricular hydrocephalus. One patient presented with a partial Parinaud's sign, but the focal and long tract signs were conspicuously absent in the other patients. The diagnosis of a space occupying lesion in the tectum mesencephali or in the aqueduct could only be ascertained with the recent use of M.R.I. The radiological work-up of the cases suggest that theses lesions, presumably of glial origin, are very slowly growing tumors. Four patients have been treated for their symptomatic hydrocephalus, but no treatment of the tumor has been proposed, as the clinical state and the images remain remarkably stable. (Mean duration of follow up from the time of shunting = 3.7 years, extremes = 1.5-8 years). A review of the literature shows that not more than 48 cases of tumors of the aqueduct have been reported. Because of the small number of such observations, there are, until now, no precise informations on the management of such cases to decide if the patient will benefit of an open or stereotactic biopsy associated with radiotherapy or if one can rely on serial clinical and radiological examinations. Further information on the long term follow up is needed. 相似文献
7.
8.
9.
M. L. Margallo-Lana P. B. Moore D. W. K. Kay R. H. Perry B. E. Reid T. P. Berney & S. P. Tyrer 《Journal of intellectual disability research : JIDR》2007,51(6):463-477
Background The clinical and neuropathological features associated with dementia in Down’s syndrome (DS) are not well established. Aims To examine clinico‐pathological correlations and the incidence of cognitive decline in a cohort of adults with DS. Method A total of 92 hospitalized persons with DS were followed up from 1985 to December 2000. At outset, 87 participants were dementia‐free, with a median age of 38 years. Assessments included the Prudhoe Cognitive Function Test (PCFT) and the Adaptive Behavior Scale (ABS), to measure cognitive and behavioural deterioration. Dementia was diagnosed from case records and caregivers’ reports. Results Eighteen (21%) patients developed dementia during follow‐up, with a median age of onset 55.5 years (range 45–74). The PCFT demonstrated cognitive decline among those with a less severe intellectual disability (mild and moderate) but not among the profoundly disabled people (severe and profound). Clinical dementia was associated with neuropathological features of Alzheimer’s disease, and correlated with neocortical neurofibrillary tangle densities. At the age of 60 years and above, a little more than 50% of patients still alive had clinical evidence of dementia. Conclusions Clinical dementia associated with measurable cognitive and functional decline is frequent in people with DS after middle age, and can be readily diagnosed among less severely intellectually disabled persons using measures of cognitive function such as the PCFT and behavioural scales such as the ABS. In the more profoundly disabled people, the diagnosis of dementia is facilitated by the use of behavioural and neurological criteria. In this study, the largest prospective DS series including neuropathology on deceased patients, the density of neurofibrillary tangles related more closely to the dementia of DS than senile plaques. In people with DS surviving to middle and old age, the development of dementia of Alzheimer type is frequent but not inevitable, and some people with DS reach old age without clinical features of dementia. 相似文献
10.
筛检对肝癌死亡率影响的研究 总被引:5,自引:0,他引:5
5581名HBsAg阳性的男性随机分入周期性筛检组(A组,3712人)及对照组(B组,1869人)。A组(19155.4人年)共发生肝癌257例,B组(9785.5人年)为117例,两组的肝癌发生率分别为1342/10万与1196/10万;两组肝癌死亡分别为218与109例,肝癌死亡率分别为1138/10万与1114/10万。两组中Ⅰ期肝癌病例分别为29.6%与6.0%,差异有非常显著性意义。1、3、5年相对生存率A组为23.7%、7.0%、4.0%,B组为9.7%、4.0%、4.1%。用Poisson回归模型拟合显示,在调正年龄、初筛AFP及入列年份后,筛检对于肝癌的相对危险度为0.83,95%CI为0.68~1.03,有较弱的“保护”作用,Cox回归模型拟合结果显示当临床分期未引入模型时,筛检对于肝癌有显著的“保护”作用:危险率为0.6617,95%CI为0.5234~0.8365;而模型经调整后,危险率即接近“1”,95%CI为0.74~1.26。 相似文献