全文获取类型
收费全文 | 1078篇 |
免费 | 113篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 29篇 |
妇产科学 | 30篇 |
基础医学 | 127篇 |
口腔科学 | 41篇 |
临床医学 | 105篇 |
内科学 | 145篇 |
皮肤病学 | 16篇 |
神经病学 | 104篇 |
特种医学 | 90篇 |
外科学 | 154篇 |
综合类 | 25篇 |
预防医学 | 74篇 |
眼科学 | 56篇 |
药学 | 91篇 |
中国医学 | 2篇 |
肿瘤学 | 109篇 |
出版年
2021年 | 16篇 |
2019年 | 8篇 |
2018年 | 23篇 |
2017年 | 13篇 |
2016年 | 10篇 |
2015年 | 14篇 |
2014年 | 24篇 |
2013年 | 31篇 |
2012年 | 48篇 |
2011年 | 61篇 |
2010年 | 34篇 |
2009年 | 30篇 |
2008年 | 55篇 |
2007年 | 42篇 |
2006年 | 39篇 |
2005年 | 52篇 |
2004年 | 42篇 |
2003年 | 43篇 |
2002年 | 42篇 |
2001年 | 15篇 |
2000年 | 19篇 |
1999年 | 18篇 |
1998年 | 32篇 |
1997年 | 26篇 |
1996年 | 24篇 |
1995年 | 29篇 |
1994年 | 13篇 |
1993年 | 16篇 |
1992年 | 11篇 |
1991年 | 14篇 |
1990年 | 25篇 |
1989年 | 14篇 |
1988年 | 20篇 |
1987年 | 33篇 |
1986年 | 12篇 |
1985年 | 14篇 |
1984年 | 13篇 |
1983年 | 18篇 |
1982年 | 20篇 |
1981年 | 12篇 |
1980年 | 14篇 |
1979年 | 12篇 |
1977年 | 17篇 |
1976年 | 17篇 |
1975年 | 10篇 |
1974年 | 9篇 |
1972年 | 6篇 |
1967年 | 8篇 |
1965年 | 6篇 |
1964年 | 7篇 |
排序方式: 共有1205条查询结果,搜索用时 296 毫秒
1.
Hans D de Boer Jan van Egmond Jacques J Driessen Leo HD Booij 《Neuropsychiatric Disease and Treatment》2007,3(5):539-544
Steroidal neuromuscular blocking agents (NMBAs), such as rocuronium, are widely used in clinical anesthesia and emergency medicine to facilitate endotracheal intubation and artificial ventilation and to allow surgical access to body cavities. Reversal of neuromuscular blockade is important for the acceleration of patient recovery and prevention of postoperative residual neuromuscular blockade and reduces the incidence of severe morbidity and mortality associated with anesthesia management. Sugammadex is the first selective relaxant binding agent (SRBA) and has been designed to reverse the steroidal neuromuscular blocking drug rocuronium. Encapsulation of the rocuronium molecule by sugammadex results in a rapid decrease in free rocuronium in the plasma and subsequently at the nicotinic receptor at the motor endplate. After encapsulation, rocuronium is not available to bind to the nicotinic receptor in the neuromuscular junction. This promotes the liberation of acetylcholine receptors, and muscle activity reappears. This new concept of reversal of neuromuscular block induced by rocuronium (or vecuronium) led to impressive results in animal and phase 1 and 2 studies. Sugammadex is currently in phase 3 clinical studies and may be commercially available by 2008. 相似文献
2.
Adeno-associated virus and the development of adeno-associated virus vectors: a historical perspective. 总被引:1,自引:0,他引:1
Barrie J Carter 《Molecular therapy》2004,10(6):981-989
3.
4.
In vitro and in vivo precipitation of iodinated contrast agents when ioxaglate and papaverine are given together has been reported. To verify these reports and to investigate other medications not previously tested, the authors analyzed mixtures of contrast agents and medications in vitro with a light spectrophotometer and observed them for visible precipitates for up to 120 minutes. Previously reported incompatibilities between ionic or low-osmolality contrast media and medications were verified, and several new incompatibilities were discovered. No incompatibilities were found when the drugs tested were mixed with the new nonionic contrast media. 相似文献
5.
6.
Lorraine D. Buckberry Ian S. Blagbrough Barrie W. Bycroft P.Nicholas Shaw 《Toxicology letters》1992,60(3):241-246
The C-S lyase enzymes are responsible for the generation of mutagenic and cytotoxic metabolites via aberrant drug-metabolising pathways in mammalian tissues. We have examined human hepatic cytosolic, mitochondrial and microsomal fractions for evidence of C-S lyase activity. The cytosolic enzyme was purified using fast protein liquid chromatography over FFQ Sepharose, Mono P and Superose 12. An homogeneous protein (monitored by SDS-PAGE) was obtained following purification, and an 11-fold increase in C-S lyase specific activity was observed. The molecular weight of the enzyme was found to be 37 kDa in denaturing conditions, 82.3 kDa in non-denaturing conditions, and the C-S lyase activity was shown to co-purify with kynurenine aminotransferase activity when the transaminase activity of the enzyme was examined with kynurenine as the substrate. 相似文献
7.
8.
Barrie Anderson M.D. 《Gynecologic oncology》1994,55(3)
When ovarian cancer progresses, goals change from cure to prolongation of life with the best possible quality for the patient. Criteria for futility must be established to guide the transition from active to palliative management. Pain control can be achieved by following established WHO guidelines. Continued education of the medical community, legislators, and the public is needed to assure pain control for the cancer patient. Limited surgery or radiation can be used to control symptoms from locally progressive disease. Other symptoms to be actively controlled include nausea and vomiting, nutrition, hydration, and fatigue. Support services, including home services, psychological counseling, and nutritional support need funding for both home and hospital settings. Quality of life assessment must be as specific as possible and address the patient's concerns by self-assessment techniques. Funding must be provided to develop specific quality of life tools and to then apply them clinically, both as part of research protocols and to assess success of palliative care. 相似文献
9.
10.