全文获取类型
收费全文 | 4700篇 |
免费 | 394篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 131篇 |
妇产科学 | 74篇 |
基础医学 | 576篇 |
口腔科学 | 187篇 |
临床医学 | 529篇 |
内科学 | 954篇 |
皮肤病学 | 41篇 |
神经病学 | 510篇 |
特种医学 | 163篇 |
外科学 | 417篇 |
综合类 | 132篇 |
一般理论 | 3篇 |
预防医学 | 592篇 |
眼科学 | 57篇 |
药学 | 431篇 |
肿瘤学 | 293篇 |
出版年
2022年 | 37篇 |
2021年 | 67篇 |
2020年 | 40篇 |
2019年 | 69篇 |
2018年 | 74篇 |
2017年 | 52篇 |
2016年 | 65篇 |
2015年 | 71篇 |
2014年 | 100篇 |
2013年 | 145篇 |
2012年 | 250篇 |
2011年 | 229篇 |
2010年 | 130篇 |
2009年 | 144篇 |
2008年 | 226篇 |
2007年 | 200篇 |
2006年 | 172篇 |
2005年 | 196篇 |
2004年 | 172篇 |
2003年 | 164篇 |
2002年 | 203篇 |
2001年 | 146篇 |
2000年 | 165篇 |
1999年 | 128篇 |
1998年 | 61篇 |
1997年 | 42篇 |
1996年 | 47篇 |
1995年 | 44篇 |
1994年 | 39篇 |
1993年 | 41篇 |
1992年 | 106篇 |
1991年 | 92篇 |
1990年 | 104篇 |
1989年 | 81篇 |
1988年 | 96篇 |
1987年 | 77篇 |
1986年 | 97篇 |
1985年 | 79篇 |
1984年 | 62篇 |
1983年 | 55篇 |
1982年 | 46篇 |
1981年 | 38篇 |
1980年 | 34篇 |
1979年 | 55篇 |
1978年 | 47篇 |
1977年 | 35篇 |
1974年 | 41篇 |
1973年 | 35篇 |
1970年 | 42篇 |
1968年 | 41篇 |
排序方式: 共有5103条查询结果,搜索用时 15 毫秒
1.
2.
3.
R J Gatchel T G Mayer P Capra J Barnett P Diamond 《Archives of physical medicine and rehabilitation》1986,67(12):878-882
The present study evaluated the use of psychologic measures, in particular, the relatively new Million Behavioral Health Inventory (MBHI), in predicting change in physical function of chronic low back pain patients undergoing a functional restoration program. The first 134 consecutive patients completing this program were assessed. Results demonstrated that various clinical scales of the MBHI were predictive of improvement in physical function. In addition, various scales enabled discrimination between patients who completed the program and those who prematurely dropped out. Although this inventory shows promise in helping to predict response to treatment, no single psychologic test can reliably be used as the sole predictor in clinical cases. 相似文献
4.
5.
This article is designed to help dentists make better decisions regarding capitation programs. It focuses on approaches to costs that can be useful. An example is given that illustrates how these cost concepts might be used to analyze a capitation proposal. 相似文献
6.
Andrew R. Hoellein MD Christopher A. Feddock MD Charles H. Griffith III MD MSPH John F. Wilson PhD Donald R. Barnett MD MSPH Pat F. Bass III MD MS T. Shawn Caudill MD MSPH 《Journal of general internal medicine》2004,19(5P2):562-565
Due to recent public debate and newly imposed resident work hour restrictions, we decided to investigate the relationship of resident call status to their ambulatory patients' satisfaction. Resident continuity clinic patients were asked to rate their level of satisfaction on a 10-point Likert-type scale. Using multiple regression approaches, these data were then assessed as a function of resident call status. We found that in 646 patient encounters, patient satisfaction scores were significantly less when the resident was postcall, 8.99 ± 1.8, than when not postcall, 9.31 ± 1.3. We herein discuss etiologies and implications of these findings for both patient care and medical education. 相似文献
7.
K. F. Tait J. E. Collins J. M. Heward I. Eaves H. Snook J. A. Franklyn A. H. Barnett J. A. Todd M. Maranian A. Compston S. Sawcer S. C. L. Gough 《Diabetic medicine》2004,21(3):267-270
Aims The Type 1 diabetes susceptibility locus, IDDM2, has been mapped to a variable number of tandem repeats (VNTR) region 5′ upstream of the insulin (INS) and insulin‐like growth factor (IGF2) genes on chromosome 11p15. The function of the VNTR is uncertain; however, it may influence the thymic expression of the insulin gene and affect the development of immune self‐tolerance. The aim of this study was to investigate whether the INS VNTR region is a Type 1 diabetes‐specific locus or acting as a general autoimmunity gene. Methods We genotyped the INS‐IGF2 VNTR [using the surrogate INS?23 HphI single nucleotide polymorphism (SNP)] in 823 Graves’ disease (GD)/multiple sclerosis (MS) families, 1433 GD/MS patients and 837 healthy control subjects. Results We found no evidence of excess transmission of the allele associated with Type 1 diabetes to individuals affected by GD or MS within the families. Analysis of the case–control dataset showed no genotypic or allelic difference between the two populations. Conclusions These data suggest that the INS‐IGF2 VNTR is acting as a Type 1 diabetes‐specific susceptibility gene rather than as an influence on general autoimmunity. 相似文献
8.
K F Tait T Marshall J Berman J Carr-Smith B Rowe J A Todd S C Bain A H Barnett S C L Gough 《Diabetic medicine》2004,21(4):358-362
AIMS: Autoimmune disorders co-exist in the same individuals and in families, implying a shared aetiology. The aim of this study was to compare the prevalence of the common autoimmune diseases in the parents of siblings from the Type 1 diabetes Warren repository with the general population. METHODS: Between 1989 and 1996, 505 British families with at least two siblings affected by Type 1 diabetes were recruited. Clinical information was collected regarding the presence of autoimmune disease in the parents and the prevalence of disease in the parents was compared with that expected in the general population. RESULTS: The prevalence of autoimmune disease in the parents was significantly higher in the repository compared with that expected in the general population [P-value = 1.98 x 10(-5) (female), P-value = 1.1 x 10(-8) (male)]. Type 1 diabetes was recorded in 63/1010 (6.2%) parents with a marked paternal preponderance (9.5 vs. 3%P = 0.002). Other autoimmune diseases affected 27% of parents with diabetes and 13.2% of parents without diabetes (P < 0.01). CONCLUSION: These data confirm the importance of family history as a significant risk factor for the development of Type 1 diabetes and support the hypothesis that the common autoimmune diseases share at least some aetiological mechanisms. 相似文献
9.
G Barnett 《Molecular pharmacology》1986,29(4):378-382
Metal cation binding to N7 of guanine (G) and the resulting altered interaction with cytosine (C) were investigated by ab initio quantum chemical calculations for the ions Li+, Na+, B+, Be2+, and Mg2+. It was found that the CG H-bonding interaction becomes more stable and the stacking interaction less stable as the charge density for the ion (ion charge/ionic radius) increases. From this observation a hypothesis is presented for a structure-activity relationship, which is supported by in vivo animal data, that may permit the design of less toxic analogues of the antitumor agent cisplatin. 相似文献
10.
Physical activity is an important, but often underused, therapeutic strategy within diabetes care. To date, little is known about the best way to promote physical activity in diabetes care. Physical activity consultation is an intervention designed to promote physical activity behaviour change. This article provides guidelines on how to conduct a physical activity consultation with people who have Type 2 diabetes, and reviews the evidence surrounding the effectiveness of this intervention in this population. The trans-theoretical model is the underlying theory of behaviour change for the physical activity consultation intervention. The review identifies research which supports the use of this model for understanding physical activity behaviour in people with Type 2 diabetes. The review outlines a number of modifiable variables associated with physical activity behaviour change in this population. How each of these variables is addressed within the guidelines for conducting a physical activity consultation is identified. Finally, limited but consistent research highlights the effectiveness of physical activity consultation for promoting physical activity in people with Type 2 diabetes. 相似文献