全文获取类型
收费全文 | 298篇 |
免费 | 6篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 3篇 |
基础医学 | 84篇 |
口腔科学 | 1篇 |
临床医学 | 43篇 |
内科学 | 70篇 |
皮肤病学 | 1篇 |
神经病学 | 12篇 |
特种医学 | 1篇 |
外科学 | 25篇 |
预防医学 | 19篇 |
眼科学 | 2篇 |
药学 | 24篇 |
肿瘤学 | 13篇 |
出版年
2023年 | 6篇 |
2021年 | 5篇 |
2020年 | 2篇 |
2019年 | 4篇 |
2017年 | 5篇 |
2015年 | 3篇 |
2014年 | 4篇 |
2013年 | 4篇 |
2012年 | 9篇 |
2011年 | 24篇 |
2010年 | 15篇 |
2009年 | 2篇 |
2008年 | 15篇 |
2007年 | 15篇 |
2006年 | 8篇 |
2005年 | 12篇 |
2004年 | 6篇 |
2003年 | 9篇 |
2002年 | 5篇 |
2001年 | 6篇 |
2000年 | 6篇 |
1999年 | 4篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1993年 | 2篇 |
1992年 | 9篇 |
1991年 | 10篇 |
1990年 | 5篇 |
1989年 | 5篇 |
1988年 | 6篇 |
1987年 | 8篇 |
1986年 | 10篇 |
1985年 | 5篇 |
1984年 | 7篇 |
1983年 | 5篇 |
1980年 | 4篇 |
1979年 | 9篇 |
1978年 | 4篇 |
1976年 | 2篇 |
1975年 | 3篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1972年 | 4篇 |
1971年 | 2篇 |
1970年 | 3篇 |
1969年 | 2篇 |
1968年 | 4篇 |
1967年 | 3篇 |
1965年 | 3篇 |
排序方式: 共有305条查询结果,搜索用时 15 毫秒
1.
Lipopolysaccharide-dependent and lipopolysaccharide-independent pathways of monocyte desensitisation to lipopolysaccharides 总被引:1,自引:0,他引:1
The present study demonstrates that with time in culture blood monocytes (MO) lose their ability to express procoagulant activity (PCA) and secrete tumor necrosis factor-alpha (TNF alpha) in culture medium in response to lipopolysaccharide (LPS) stimulation. Thus, upon 10 micrograms/ml LPS stimulation for 4 hours 2-day-old MO produced lower levels of PCA and TNF alpha than fresh MO. The decrease in responsiveness was not caused by cell death, since in the case of TNF alpha it was fully reversible by interferon-gamma (IFN-gamma). Compared with cells pre-incubated in medium alone, the responsiveness of MO pre-incubated in LPS was further decreased. Thus, in MO LPS pre-incubation was followed by an LPS refractory state. It was expected that the decrease in responsiveness induced by cultivation in medium alone was mediated by LPS contamination of culture medium. However, as we were unable to prevent this decrease by neutralizing LPS contamination of the culture medium with polymyxin B, the loss in LPS-induced activities of cultured MO is likely to be mediated by culture conditions other than LPS contamination. Taken together the present data demonstrate that LPS-dependent as well as LPS-independent pathways of MO desensitization to LPS exist. 相似文献
2.
The action of continuous low-frequency vibration on rats for 1 month caused no changes in the total adenine nucleotides of the brain but led to a marked decrease in the ATP content and total adenine nucleotides in the limb muscles. After exposure to vibration for 3 months considerable exhaustion of the total adenine nucleotides of both muscles and brain was found. In the case of interrupted exposure to vibration the state of the adenine-nucleotide system depended on the duration of the pauses between periods of continuous exposure to vibration. During vibration with the shortest pauses (4 min) between successive periods of 30 min of vibration no changes were observed in the energy metabolism of the muscles and brain. Vibration with pauses of 8 and 15 min was found to be unfavorable for the adenine nucleotides of the muscles and vibration with a pause of 8 min for the brain.Kiev Institute of Work Hygiene and Occupational Diseases, (Presented by Academician of the Academy of Medical Sciences of the USSR L. I. Medved'.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 7, pp. 35–38, July, 1978. 相似文献
3.
4.
F. S. Baranova A. A. Berman Yu. M. Zaretskaya 《Bulletin of experimental biology and medicine》1980,89(1):44-46
1-Antitrypsin (1-AT) reduces the intensity of transformation of human peripheral blood lymphocytes stimulated by phytohemagglutinin. The degree of inhibition is determined by the antiprotease activity of the 1-AT. Maximal inhibition of transformation was shown to be 50%. Participation of 1-AT in the control of activity of lymphoid tissue cells is postulated.Laboratory of Immunogenetics, Research Institute of Transplantology and Artificial Organs, Ministry of Health of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. N. Orekhovich.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 89, No. 1, pp. 35–36, January, 1980. 相似文献
5.
V. G. Ablamunits V. N. Blyumkin G. M. Mogilevskii L. A. Kirsanova F. S. Baranova 《Bulletin of experimental biology and medicine》1990,110(6):1718-1721
Research Institute of Transplantology and Artificial Organs, Ministry of Health of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 110, No. 12, pp. 650–653, December, 1990. 相似文献
6.
Baranova IP 《Problemy sot?sial?no? gigieny, zdravookhranenii?a i istorii medit?siny / NII sot?sial?no? gigieny, ?konomiki i upravlenii?a zdravookhraneniem im. N.A. Semashko RAMN ; AO "Assot?siat?sii?a 'Medit?sinskai?a literatura'."》1999,(6):15-17
Preterm babies are at risk of sudden death. Determination of the risk factors and prediction of the probability of sudden death syndrome in infants will help the physicians in purposeful observation of the risk-group children, improve the efficacy of prophylactic check-ups, and decrease neonatal mortality. A prognostic table for rapid diagnosis of the risk of sudden death syndrome is proposed for practical public health. 相似文献
7.
Dietary polyamines promote the growth of azoxymethane-induced aberrant crypt foci in rat colon 总被引:1,自引:1,他引:1
We have examined whether dietary polyamines influence the formation and
initial growth of azoxymethane (AOM)-induced aberrant crypt foci (ACF) in
rat colon. Effects of a combination of dietary polyamines at three dose
levels (putrescine: 50, 280, 740 nmol/g; spermidine: 10, 261, 763 nmol/g;
spermine: 1, 31, 91 nmol/g) in the polyamine-poor AIN-76A diet were studied
in animals in two different experimental situations: animals treated with
AOM alone and animals treated with AOM + difluoromethylornithine (DFMO), a
specific inhibitor of endogenous polyamine synthesis. In both experimental
situations, dietary polyamines enhanced the growth of ACF, expressed as the
number of large ACF (foci with three or more aberrant crypts, ACF > or =
3), whereas the formation of ACF, expressed as the number of ACF, was
apparently not altered. In animals treated with AOM alone, maximal growth
enhancing effect on ACF was nearly obtained with the median level of
dietary polyamine. In rats fed a low polyamine diet, basic AIN-76A, DFMO
reduced the growth of AOM-induced ACF by 83%. This inhibitory effect of
DFMO was counteracted by dietary polyamines in a dose- dependent manner,
and it was abolished at the highest level of polyamines. In conclusion, it
was demonstrated that dietary polyamines are able to enhance the growth of
AOM-induced ACF. Further, dietary polyamines reversed the DFMO-caused
inhibition of ACF growth, probably by compensating for the DFMO-reduced
endogenous polyamine synthesis.
相似文献
8.
Long exposure to small radio activity doses have no impact on the acuity of photopic and mesopic vision, on the resistance of eyes to glare, and on the rapidity of color differentiation, which remain to be at the high level that meets medical requirements for the professional abilities of locomotive workers. 相似文献
9.
10.
Ordyan N. E. Pivina S. G. Baranova K. A. Rakitskaya V. V. Akulova V. K. Kholova G. I. 《Neuroscience and behavioral physiology》2021,51(3):357-366
Neuroscience and Behavioral Physiology - Prenatal stress is regarded as a risk factor for the development of diseases such as mental, cardiovascular, and metabolic disorders in later life.... 相似文献