全文获取类型
收费全文 | 3308篇 |
免费 | 193篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 276篇 |
妇产科学 | 56篇 |
基础医学 | 335篇 |
口腔科学 | 76篇 |
临床医学 | 249篇 |
内科学 | 652篇 |
皮肤病学 | 135篇 |
神经病学 | 127篇 |
特种医学 | 201篇 |
外科学 | 417篇 |
综合类 | 166篇 |
预防医学 | 164篇 |
眼科学 | 187篇 |
药学 | 280篇 |
中国医学 | 12篇 |
肿瘤学 | 166篇 |
出版年
2023年 | 26篇 |
2022年 | 60篇 |
2021年 | 104篇 |
2020年 | 58篇 |
2019年 | 70篇 |
2018年 | 85篇 |
2017年 | 94篇 |
2016年 | 104篇 |
2015年 | 100篇 |
2014年 | 155篇 |
2013年 | 174篇 |
2012年 | 221篇 |
2011年 | 198篇 |
2010年 | 139篇 |
2009年 | 123篇 |
2008年 | 181篇 |
2007年 | 149篇 |
2006年 | 134篇 |
2005年 | 112篇 |
2004年 | 99篇 |
2003年 | 72篇 |
2002年 | 59篇 |
2001年 | 61篇 |
2000年 | 55篇 |
1999年 | 53篇 |
1998年 | 67篇 |
1997年 | 62篇 |
1996年 | 41篇 |
1995年 | 36篇 |
1994年 | 34篇 |
1993年 | 38篇 |
1992年 | 46篇 |
1991年 | 31篇 |
1990年 | 39篇 |
1989年 | 45篇 |
1988年 | 46篇 |
1987年 | 51篇 |
1986年 | 28篇 |
1985年 | 40篇 |
1984年 | 25篇 |
1983年 | 17篇 |
1982年 | 18篇 |
1981年 | 12篇 |
1980年 | 13篇 |
1979年 | 22篇 |
1978年 | 21篇 |
1977年 | 11篇 |
1975年 | 13篇 |
1974年 | 13篇 |
1973年 | 14篇 |
排序方式: 共有3524条查询结果,搜索用时 62 毫秒
1.
Akira Sawaki Nobumasa Mizuno Kuniyuki Takahashi Tsuneya Nakamura Masahiro Tajika Hiroki Kawai Toshifumi Isaka Hiroshi Imaoka Yasuyuki Okamoto Masatoshi Aoki Hiroyuki Inoue Ahmed AS Salem Yasushi Yatabe Kenji Yamao 《Digestive endoscopy》2006,18(1):40-44
Background: Gastrointestinal stromal tumors (GIST) are one of the most common mesenchymal tumors of the gastrointestinal tract. GIST are defined by positive immunohistochemical staining for KIT or CD34 and thus are generally diagnosed after surgery. Because small GIST are rarely diagnosed before surgery, the clinical course of these small tumors is not clear. The aim of the present study was to follow changes in size and configuration of small GIST that were pathologically confirmed using endoscopic ultrasonography‐guided fine‐needle aspiration biopsy (EUS‐FNAB). Methods: Between July 1997 and December 2003, 16 tumors in 16 patients (10 men and 6 women) with an immunohistochemical diagnosis of GIST were regularly followed in our hospital. The median patient age when EUS‐FNAB was performed was 62 years (range 26–82 years) and the median follow‐up period was 4.9 years (range 0.5–9.6 years). Results: Fourteen tumors showed no remarkable changes in size and shape during follow up compared with the initial diagnosis. Two tumors enlarged: one tumor approximately doubled its diameter in 8 years and the other tumor increased from 1.8 cm at diagnosis to up to 10 cm after only 2 years. Doubling time of the latter tumor was calculated as 3.1 months. Conclusions: We conclude that EUS‐FNAB might be a good modality for final diagnosis of GIST without surgery, and that GIST without rapid growth on follow up can be endoscopically followed. 相似文献
2.
3.
Coronary artery bypass grafts: visualization with MR imaging 总被引:1,自引:0,他引:1
4.
A S Bansal R Chee V Nagendran A Warner G Hayman 《Journal of investigational allergology & clinical immunology》2007,17(3):189-191
Brazil nuts are the second most frequent cause of nut allergy in the United Kingdom. We report the case of a 20-year-old woman with documented Brazil nut allergy who developed widespread urticaria and mild dyspnea after intercourse with her boyfriend who had earlier consumed Brazil nuts. Skin prick testing with the boyfriend's semen after Brazil nut consumption confirmed significant reactivity whereas a sample before nut consumption was negative. We believe this to be the first case of a sexually transmitted allergic reaction. 相似文献
5.
6.
7.
Ramona A. Cole Anita Bansal Debra M. Moriarity William A. Haber William N. Setzer 《Journal of natural medicines》2007,61(4):414-417
The leaf essential oil of Eugenia zuchowskiae from Monteverde, Costa Rica, has been obtained by hydrodistillation and analyzed by GC–MS. The principal constituents of
E. zuchowskiae leaf oil were α-pinene (28.3%), β-caryophyllene (13.2%), α-humulene (13.1%), and α-copaene (8.1%). The leaf essential oil
of E. zuchowskiae showed pronounced in-vitro cytotoxic activity against MCF-7, MDA-MB-468, and UACC-257 human tumor cell lines. The major components
showed cytotoxic activities comparable to doxorubicin (LC50 14–70 μg/ml). 相似文献
8.
A gradual reduction in cell-mediated immunity is thought to occur with the progression of human immunodeficiency virus (HIV) infection. This suggests a selective attrition of the Th1 subset. The regulation of the soluble form of the low-affinity receptor for IgE (sCD23) by the opposing actions of interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) allows the assessment of the overall balance of Th1 to Th2 activity in a given disease. In order to investigate this further we employed an enhanced chemiluminescent ELISA to analyse serum levels of sCD23 in male subjects with and without HIV infection. Serum levels of sCD23 were similar in 34 HIV seronegative homosexuals, 39 homosexuals with asymptomatic HIV infection, 27 homosexuals with acquired immune deficiency syndrome (AIDS) and 20 healthy controls. This suggests that HIV has no predilection for either the Th1 or Th2 subsets of CD4 T cells. 相似文献
9.
10.
Ajit Sood Vandana Midha Neena Sood Manu Bansal 《Indian journal of gastroenterology》2006,25(6):283-285
BACKGROUND: The treatment of hepatitis C virus (HCV)-related cirrhosis is difficult due to high frequency of adverse effects. We retrospectively reviewed the case records of patients with HCV cirrhosis to evaluate the efficacy and tolerability of pegylated (peg) interferon and ribavirin treatment in these patients. METHODS: Medical records of 28 patients with HCV-related compensated cirrhosis were reviewed. The treatment protocol was a combination therapy of peg interferon alfa-2b (1 microg/Kg/week) plus oral ribavirin (10-12 mg/Kg/day). Primary endpoint was sustained virological response, with additional endpoints of drug tolerance, clinical or biochemical worsening and death. RESULTS: End-of-treatment virlogic response was seen in 24 of 28 patients (85%) and sustained virologic response in 15 of 28 (53%) patients. Biochemical end-of-treatment response and sustained response were seen in 20 and 16 patients (71% and 57%), respectively. Treatment had to be stopped in 3 patients due to decompensation of liver status in two and drug intolerance in one, while dose modification was required in two patients. CONCLUSIONS: Combination therapy with peg interferon plus ribavirin seems effective in patients with liver cirrhosis. High relapse rate, poor biochemical recovery and possibility of decompensation are issues that need to be kept in mind. 相似文献