Sternberg-Reed Cells in the Peripheral Blood of Patients with Hodgkin's Disease

Our observations of 135 patients indicate that 37 per cent of those sufferingfrom Hodgkin’s disease exhibit abnormal cells in the leukocyte concentrates ofthe peripheral blood during the course of their illness. Typical Sternberg-Reedcells were found in 18.5 per cent of patients and were present only in theadvanced stages of generalized Hodgkin’s disease.

The presence of Sternberg-Reed cells in the peripheral blood indicates anadvanced stage of the disease but does not necessarily predict an immediatelyfatal outcome.

Comparative studies, searching for Sternberg-Reed cells in the splenic circulation, showed no Sternberg-Reed cells to be present in the splenic arteries ofpatients with Hodgkin’s disease; but numerous Sternberg-Reed cells were present in the splenic vein, particularly after mechanical squeezing of the spleen.A possible hypothesis is given to support the evidence for the circulation ofSternberg-Reed cells and an explanation for their lower incidence in the peripheral blood.

Our observations support the hematogenous metastasis of Hodgkin’s disease.

Submitted on June 2, 1965 Accepted on August 2, 1965     

GLYCOSYLATED HEMOGLOBIN (HbAtc) AND PLASMA LIPOPROTEINS IN JUVENILE ONSET DIABETES MELLITUS

Abstract. Pollak, A., Widhalm, K., Havelec, L., Frisch, H. and Schober, E. (Division of Neonatology and Congenital Disorders, Department of Paediatrics and Institute for Medical Statistics and Documentation, University of Vienna, Vienna, Austria). Glycosylated hemoglobin (HbA_1c) and plasma lipoproteins in juvenile onset diabetes mellitus. Acta Paediatr Scand, 69:475, 1980.—Plasma lipid and lipoprotein levels and hemoglobin A_1c. estimates of diabetic control were measured in 19 juvenile-onset diabetics (8 girls and 11 boys) upon admission (day 1) and at the end (day 25) of a 4-week summer camp, where the patients were put on a controlled diet with a daily linoleic acid intake of about 16 g. Lipoproteins were also measured in 64 healthy controls. When values on day 25 were compared with those of day one, a slight but significant decrease in mean hemoglobin Ate (10.4±0.3 vs. 9.8±0.4% of total Hb; M±S.E.M.; p < 0.05) was noted, as well as an increase in mean high density lipoprotein cholesterol (1.0±0.07 vs. 1.3±0.1 mmol/l; M±S.E.M.; p < 0.02) and a decrease in mean triglycerides (1.2±0.1 vs. 0.7±0.04 mmol/l; M±S.E.M.; p < 0.001). A linear correlation was found between hemoglobin A_1c on day 25 and urine glucose excretion during the camping period ( p < 0.01). However, no relationship was noted between hemoglobin A_1c and either lipids or lipoproteins. Other factors, e.g. the controlled intake of saturated fat or physical activity could have been responsible for the changes in triglycerides and high-density lipoprotein cholesterol levels noted by the end of the camp     

Leukemic Reticuloendotheliosis

The anatomical and functional featuresof the hairy cells of leukemic reticuloendothelisis were investigated by timelapse cinematography; phytohemagglutinin stimulation; adherence to siliconizedsurfaces; a variety of cytochemicalmethods; and phase, transmission, andscanning electron microscopy. The scanning electron microscopic image supportsthe morphologic evidence for a relationship between the hairy and the reticularcells.

Submitted on February 24, 1971 Revised on April 1, 1971 Accepted on April 13, 1971