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Padula A Chin NW Azeez S Resetkova E Andriko JA Miettinen M 《Annals of diagnostic pathology》2005,9(1):49-53
We describe a rare case of malignant gastrointestinal stromal tumor (GIST) of the esophagus presenting in an HIV-positive man. Not only did the tumor arise from an unusual anatomic site for GIST, namely, the esophagus, but it also had a predominant epithelioid cell morphology that is uncommon and preferentially associated with aggressive behavior. Exhaustive immunohistochemical studies showed strong reactivities to the classic GIST marker, CD34, and to the current more sensitive and more specific GIST marker, CD117/ c-kit protein. This immunophenotype corresponded to that of stromal tumors arising in the more common sites like stomach and small intestine as well as to that of a reported series of esophageal GISTs in the general population. Mutations of the c-kit protein was detected in the tumor, confirming previous observations. This further documents that esophageal GIST and the more common benign esophageal spindle cell lesions are pathologically distinct entities and despite its rarity, esophageal GIST should be recognized by pathologists and clinicians. The occurrence of this tumor in an HIV-positive patient is coincidental, and it resulted in an extremely unusual metastatic site that has not been reported for GISTs. 相似文献
3.
Abdul Azeez E P G. Anbu Selvi Garima Sharma Senthil Kumar A P 《The International journal of health planning and management》2021,36(1):83-99
The practice of allopathic medicine by informal healthcare practitioners (IHPs) is ubiquitous in India. However, a little is known about the patients' experiences and IHPs' perspectives. The core questions guided the present study were (1) why do urban poor approach IHPs for healthcare? (2) what are their experiences of availing services from IHPs? and (3) what are the perspectives of IHPs about their practice with the population they serve? A qualitative research design guided the study. The study was conducted in the Gurugram city of Haryana, India. Nine IHPs and twenty‐seven patients who fit into the pre‐established inclusion criteria were interviewed. The findings of the study underline the structural constrains of healthcare access to the poor in India and the mutual dependencies between IHPs and the urban poor. Three themes were emerged corresponding to the perspectives of IHPs, and five themes were generated, which describes patients' experiences and perspectives of availing treatment. The factors that attract and sustain patients to IHPs are a mixture of socio‐economic aspects, which include poverty, inaccessibility, unaffordability, inefficient public healthcare facilities, and the positive behavioural and treatment attributes of the practitioners. The study implies urgent policy interventions to ensure quality healthcare to urban poor. 相似文献
4.
Yinusa Raji Olumide S. Akinsomisoye Mistura O. Azeez 《Reproductive Medicine and Biology》2006,5(3):201-209
Aim: To investigate the impact and possible mechanism of action of the rodent malarial parasite on reproduction.
Methods: Male albino mice were infected with 15, 30 and 45% Plasmodium berghei berghei through inoculation with 107 parasitized red blood cells. Each experiment had its own control that was not infected with P. berghei berghei . Mice infected with 15% P. berghei berghei were killed on days 0, 5, 10 and 15; those infected with 30% P. berghei berghei were killed on days 0, 3, 6 and 10; and those infected with 45% P. berghei berghei were killed on days 1–7 after infection. Caudal epididymal sperm motility, counts and morphology, body and wet organ weights and hematological indices were determined.
Results: The results showed a progressive duration dependent decrease in sperm motility, sperm count and viability ( P < 0.01) in parasitized mice. There were significant decreases in serum testosterone and increases in cortisol levels ( P < 0.05) in the infected mice compared with the controls. There was also a progressive decrease ( P < 0.05) in red blood cell count and packed cell volume. However, there was a progressive increase ( P < 0.01) in white blood cell count and weight of the spleen and liver. There was no significant change in weight of the testis and epididymides.
Conclusion: The results suggest that the malaria parasite could depress male fertility indices. (Reprod Med Biol 2006; 5 : 201–209) 相似文献
Methods: Male albino mice were infected with 15, 30 and 45% Plasmodium berghei berghei through inoculation with 10
Results: The results showed a progressive duration dependent decrease in sperm motility, sperm count and viability ( P < 0.01) in parasitized mice. There were significant decreases in serum testosterone and increases in cortisol levels ( P < 0.05) in the infected mice compared with the controls. There was also a progressive decrease ( P < 0.05) in red blood cell count and packed cell volume. However, there was a progressive increase ( P < 0.01) in white blood cell count and weight of the spleen and liver. There was no significant change in weight of the testis and epididymides.
Conclusion: The results suggest that the malaria parasite could depress male fertility indices. (Reprod Med Biol 2006; 5 : 201–209) 相似文献
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Ismail O. Ishola Onyinyechi E. Akataobi Azeez A. Alade Olufunmilayo O. Adeyemi 《Fundamental & clinical pharmacology》2019,33(3):277-285
There is a growing number of epidemiological and molecular studies which suggest that diabetes is associated with an increased risk of Parkinson's disease (PD). Hence, in this study, the effect of glimepiride (GPD), a sulphonylurea (antidiabetic) on paraquat (PQT)‐induced Parkinsonism was evaluated in mice. Thirty‐six mice were randomly divided into six groups (n = 6) and treated orally for 21 consecutive days as follows: Group 1: vehicle (10 mL/kg), Group 2: PQT (10 mg/kg, i.p., twice per week for 3 weeks), Group 3–5: GPD (1, 2 or 4 mg/kg) + PQT (10 mg/kg, i.p., twice per week for 3 weeks), Group 6: GPD (4 mg/kg, p.o.). The effects of the treatment on motor coordination were evaluated using the rotarod performance, bar and open field tests while working memory was assayed using Y‐maze test. Paraquat injection induced significant decrease in falling time, number of crosses and percentage alternation behaviour with a concomitant increase in the duration of cataleptic behaviour in the rotarod, open field, Y‐maze and bar tests, respectively, which was ameliorated by GPD treatment. PQT also increased lipid peroxidation, peroxynitrite and TNF‐α generations as well as deficit in superoxide dismutase and GSH activities in the midbrain. PQT‐induced oxidative stress and neuroinflammation was attenuated by GPD treatment. Findings from this study showed that GPD prevents PQT‐induced motor dysfunction, memory impairment, oxidative stress and neuroinflammation through enhancement of antioxidant defense system and inhibition of pro‐inflammatory cytokine release. Thus, GPD could be a potential adjunct in the management of Parkinsonism. 相似文献
7.
Philip A. Adeniyi Azeez O. Ishola Babafemi J. Laoye Babawale P. Olatunji Oluwamolakun O. Bankole Philemon D. Shallie Olalekan M. Ogundele 《Metabolic brain disease》2016,31(1):93-107
The interaction between MDMA and Nicotine affects multiple brain centres and neurotransmitter systems (serotonin, dopamine and glutamate) involved in motor coordination and cognition. In this study, we have elucidated the effect of prolonged (10 days) MDMA, Nicotine and a combined Nicotine-MDMA treatment on motor-cognitive neural functions. In addition, we have shown the correlation between the observed behavioural change and neural structural changes induced by these treatments in BALB/c mice. We observed that MDMA (2 mg/Kg body weight; subcutaneous) induced a decline in motor function, while Nicotine (2 mg/Kg body weight; subcutaneous) improved motor function in male periadolescent mice. In combined treatment, Nicotine reduced the motor function decline observed in MDMA treatment, thus no significant change in motor function for the combined treatment versus the control. Nicotine or MDMA treatment reduced memory function and altered hippocampal structure. Similarly, a combined Nicotine-MDMA treatment reduced memory function when compared with the control. Ultimately, the metabolic and structural changes in these neural systems were seen to vary for the various forms of treatment. It is noteworthy to mention that a combined treatment increased the rate of lipid peroxidation in brain tissue. 相似文献
8.
Correlation of intraoperative cytological and final histological diagnoses: A retrospective 10‐year study of neurosurgical cases from Ibadan,Nigeria
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A. Salami M.B.B.S. A. Azeez M.B.B.S. A. Malomo M.B.B.S. A. Oluwasola M.B.B.S. A. Adeleye M.B.B.S. G. Ogun M.B.B.S. A. Adeoye M.B.C.H.B. A. Adeolu M.B.C.H.B. C. Okolo M.B.B.S. U. Eze M.B.B.S. Y. Abdullahi M.B.B.S. A. Lawan M.B.B.S. J. Ogunbiyi M.B.B.S. E. Akang M.B.B.S. M. Shokunbi M.B.B.S. 《Diagnostic cytopathology》2015,43(3):195-201
9.
Azeez Butali Satoshi Suzuki Margaret E. Cooper Adela M. Mansilla Karen Cuenco Elizabeth J. Leslie Yasushi Suzuki Teruyuki Niimi Masahiko Yamamoto Gongorjav Ayanga Tudevdorj Erkhembaatar Hiroo Furukawa Kumiko Fujiwawa Hideto Imura Aline L. Petrin Nagato Natsume Terri H. Beaty Mary L. Marazita Jeffery C. Murray M.D. 《American journal of medical genetics. Part A》2013,161(5):965-972
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