全文获取类型
收费全文 | 6099篇 |
免费 | 502篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 74篇 |
儿科学 | 212篇 |
妇产科学 | 141篇 |
基础医学 | 661篇 |
口腔科学 | 147篇 |
临床医学 | 734篇 |
内科学 | 1110篇 |
皮肤病学 | 91篇 |
神经病学 | 567篇 |
特种医学 | 285篇 |
外科学 | 883篇 |
综合类 | 137篇 |
一般理论 | 2篇 |
预防医学 | 740篇 |
眼科学 | 149篇 |
药学 | 331篇 |
1篇 | |
中国医学 | 6篇 |
肿瘤学 | 344篇 |
出版年
2023年 | 62篇 |
2022年 | 100篇 |
2021年 | 224篇 |
2020年 | 95篇 |
2019年 | 161篇 |
2018年 | 193篇 |
2017年 | 130篇 |
2016年 | 129篇 |
2015年 | 165篇 |
2014年 | 193篇 |
2013年 | 258篇 |
2012年 | 320篇 |
2011年 | 330篇 |
2010年 | 171篇 |
2009年 | 181篇 |
2008年 | 274篇 |
2007年 | 272篇 |
2006年 | 221篇 |
2005年 | 236篇 |
2004年 | 219篇 |
2003年 | 189篇 |
2002年 | 158篇 |
2001年 | 137篇 |
2000年 | 161篇 |
1999年 | 121篇 |
1998年 | 87篇 |
1997年 | 75篇 |
1996年 | 82篇 |
1995年 | 51篇 |
1994年 | 77篇 |
1993年 | 57篇 |
1992年 | 90篇 |
1991年 | 98篇 |
1990年 | 90篇 |
1989年 | 96篇 |
1988年 | 96篇 |
1987年 | 68篇 |
1986年 | 74篇 |
1985年 | 56篇 |
1984年 | 66篇 |
1983年 | 69篇 |
1982年 | 55篇 |
1981年 | 45篇 |
1980年 | 41篇 |
1979年 | 58篇 |
1978年 | 56篇 |
1976年 | 29篇 |
1974年 | 28篇 |
1973年 | 32篇 |
1970年 | 29篇 |
排序方式: 共有6615条查询结果,搜索用时 15 毫秒
1.
2.
D Monnier† C Vidal‡ L Martin§ A Danzon¶ F Pelletier† E Puzenat† MP Algros†† D Blanc† R Laurent† PH Humbert† F Aubin† 《Journal of the European Academy of Dermatology and Venereology》2006,20(10):1237-1242
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumour of the skin, with an estimated incidence of 0.8 to five cases per 1 million people per year. OBJECTIVE: To study epidemiological, immunohistochemical and clinical features, delay in diagnosis, type of treatment and outcome of DFSP from 1982 to 2002. METHODS: Using data from the population-based cancer registry, 66 patients with pathologically proved DFSP were included (fibrosarcomatous DFSP were excluded). Each patient lived in one of the four departments of Franche-Comté (overall population of 1 million people) at the time of diagnosis. The main data sources came from public and private pathology laboratories and medical records. The rules of the International Agency for Research on Cancer were applied. RESULTS: The estimated incidence of DFSP in Franche-Comté was about three new cases per 1 million people per year. Male patients were affected 1.2 times as often as female patients were. The trunk (45%) followed by the proximal extremities (38%) were the most frequent locations. DFSP occurred mainly in young adults between 20 and 39 years of age. Mean age at diagnosis was 43 years, and the mean delay in diagnosis was 10.08 years. Our 66 patients initially underwent a radical local excision. Among them, 27% experienced one or more local recurrences during 9.6 years of follow-up. There was one regional lymph node recurrence without visceral metastases. These recurrences were significantly related to the initial peripheral resection margins. We observed a local recurrence rate of 47% for margins less than 3 cm, vs. only 7% for margins ranging from 3 to 5 cm [P=0.004; OR=0.229 (95%, CI=0.103-0.510)]. The mean time to a first local recurrence was 2.65 years. Nevertheless, there was no death due to the DFSP course at the end of the follow-up, and the final outcome was favourable. CONCLUSION: Our study emphasizes the importance of wide local excision with margins of at least 3 cm in order to prevent local recurrence. However, the recent development of inhibitors of signal transduction by the PDGFB pathway should soon modify the surgical strategy, which is often too mutilating. 相似文献
3.
4.
5.
6.
Dopaminergic involvement in locomotion elicited from the ventral pallidum/substantia innominata 总被引:1,自引:0,他引:1
Microinjection of the indirect GABAA antagonist, picrotoxin, or the mu opioid agonist, Tyr-D-Ala-Gly-NMe-Phe-Gly-ol (DAGO), into the ventral pallidum and substantia innominata (VP/SI) increases locomotor activity in rats. The VP/SI has direct and indirect projections to the region of the ventral mesencephalon containing dopamine perikarya, and to certain dopamine terminal fields, including the nucleus accumbens. Thus, it is possible that modulation of the mesocorticolimbic dopamine system by pharmacological stimulation in the VP/SI may play a role in the locomotor stimulant response. It was shown that pretreatment with dopamine receptor antagonists, either peripherally or microinjected into the nucleus accumbens significantly attenuated the motor stimulant effect of DAGO or picrotoxin injection into the VP/SI. Injection of either picrotoxin or DAGO into the VP/SI increased the levels of dopamine metabolites in the nucleus accumbens and prefrontal cortex. Thus, the motor stimulant response following pharmacological stimulation of the VP/SI appears to be mediated by increased dopamine neurotransmission via feedback mechanisms to the mesocorticolimbic dopamine system. 相似文献
7.
8.
Olfactory Neuroblastoma and Neuroendocrine Carcinoma of the Anterior Skull Base: Treatment Results at the M.D. Anderson Cancer Center 下载免费PDF全文
John R. Austin Hazel Cebrun Mathew M. Kershisnik Adel K. El-Naggar Adam S. Garden Franco DeMonte Lawrence E. Ginsberg Scott M. Lippman Helmuth Goepfert 《Skull base》1996,6(1):1-8
Updated information on the pathologic characterization and treatment of olfactory neurobiastoma (ON) and neuroendocrine carcinoma (NEC) diseases is presented. A series of patients with ON or NEC was evaluated and retrospectively staged using the UCLA system. The parameters evaluated were symptoms, age, sex, risk factor assessment, stage of disease, treatment, and clinical outcome. The median follow-up was 3 years (range, 18 months to 23 years). The predominant therapy (63%) for ON was combined surgery and radiotherapy. Surgery alone or in combination with ancillary treatment was used in 58% of patients with NEC. For the most receat years of the study, patients with NEC have been treated successfully with combined chemotherapy and radiotherapy. Seventy percent of the patients with ON and 75% of the patients with NEC were clinically free of disease during the defined follow-up period. Surgical therapy consisting of a craniofacial resection combined with postoperative radiotherapy has resulted in good local and long-term control of ON. Our experience indicates that combined chemoradiation is an appropriate therapeutic approach for NEC. 相似文献
9.
10.
Over the past decade, the unfortunate reality is that the income gap has widened between Canadian families. Educational outcomes are one of the key areas influenced by family incomes. Children from low-income families often start school already behind their peers who come from more affluent families, as shown in measures of school readiness. The incidence, depth, duration and timing of poverty all influence a child’s educational attainment, along with community characteristics and social networks. However, both Canadian and international interventions have shown that the effects of poverty can be reduced using sustainable interventions. Paediatricians and family doctors have many opportunities to influence readiness for school and educational success in primary care settings. 相似文献