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排序方式: 共有251条查询结果,搜索用时 10 毫秒
1.
Prof. Dr. Aurel von Török 《Virchows Archiv : an international journal of pathology》1900,159(2):248-288
Ohne ZusammenfassungVorgelegt in der Sitzung der Berliner Anthropologischen Gesellschaft am 21. Januar 1899. 相似文献
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Caroline E. Gebhard Catherine Gebhard Foued Maafi Marie-Jeanne Bertrand Barbara E. Stähli Karin Wildi Zurine Galvan Aurel Toma Zheng W. Zhang David Smith Hung Q. Ly 《The Canadian journal of cardiology》2018,34(6):744-751
Background
The association between diagnosed acute ST-elevation myocardial infarction (STEMI) and hockey games in the Canadian population is unknown.Methods
We retrospectively analyzed the association between hockey games of the National Hockey League Montreal Canadiens and daily hospital admissions for acute STEMI at the Montreal Heart Institute, Canada.Results
Between June 2010 and December 2014, a total of 2199 patients (25.9% women; mean age, 62.6 ± 12.4 years) were admitted for acute STEMI. An increase in STEMI admissions was observed the day after a hockey game of the Montreal Canadiens in the overall population (from 1.3 ± 1.2 to 1.5 ± 1.3), however, this difference was not significant (P = 0.1). The number of STEMI admissions increased significantly from 0.9 ± 1.0 to 1.2 ± 1.0 per day in men (P = 0.04), but not in women (P = 0.7). The association between ice hockey matches and STEMI admission rates was strongest after a victory of the Montreal Canadiens. Accordingly, an increased risk for the occurrence of STEMI was observed in the overall population (hazard ratio [HR], 1.15; 95% confidence interval [CI], 1.0-1.3; P = 0.037) when the Montreal Canadiens won a match. This association was present in men (HR, 1.2; 95% CI, 1.03-1.4; P = 0.02) but not in women (P = 0.87), with a most pronounced effect seen in younger men (younger than 55 years; HR, 1.4; 95% CI, 1.1-1.8; P = 0.009).Conclusions
Although a weak association between hockey games and hospital admissions for STEMI was found in our overall population, the event of a hockey game significantly increased the risk for STEMI in younger men. Preventive measures targeting behavioural changes could positively affect this risk. 相似文献4.
Liu J Xu Y Stoleru D Salic A 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(2):413-418
Synthesis of many proteins is tightly controlled at the level of translation, and plays an essential role in fundamental processes such as cell growth and proliferation, signaling, differentiation, or death. Methods that allow imaging and identification of nascent proteins are critical for dissecting regulation of translation, both spatially and temporally, particularly in whole organisms. We introduce a simple and robust chemical method to image and affinity-purify nascent proteins in cells and in animals, based on an alkyne analog of puromycin, O-propargyl-puromycin (OP-puro). OP-puro forms covalent conjugates with nascent polypeptide chains, which are rapidly turned over by the proteasome and can be visualized or captured by copper(I)-catalyzed azide-alkyne cycloaddition. Unlike methionine analogs, OP-puro does not require methionine-free conditions and, uniquely, can be used to label and assay nascent proteins in whole organisms. This strategy should have broad applicability for imaging protein synthesis and for identifying proteins synthesized under various physiological and pathological conditions in vivo. 相似文献
5.
Busche MA Chen X Henning HA Reichwald J Staufenbiel M Sakmann B Konnerth A 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(22):8740-8745
Alzheimer's disease (AD) is characterized by a progressive dysfunction of central neurons. Recent experimental evidence indicates that in the cortex, in addition to the silencing of a fraction of neurons, other neurons are hyperactive in amyloid-β (Aβ) plaque-enriched regions. However, it has remained unknown what comes first, neuronal silencing or hyperactivity, and what mechanisms might underlie the primary neuronal dysfunction. Here we examine the activity patterns of hippocampal CA1 neurons in a mouse model of AD in vivo using two-photon Ca(2+) imaging. We found that neuronal activity in the plaque-bearing CA1 region of older mice is profoundly altered. There was a marked increase in the fractions of both silent and hyperactive neurons, as previously also found in the cortex. Remarkably, in the hippocampus of young mice, we observed a selective increase in hyperactive neurons already before the formation of plaques, suggesting that soluble species of Aβ may underlie this impairment. Indeed, we found that acute treatment with the γ-secretase inhibitor LY-411575 reduces soluble Aβ levels and rescues the neuronal dysfunction. Furthermore, we demonstrate that direct application of soluble Aβ can induce neuronal hyperactivity in wild-type mice. Thus, our study identifies hippocampal hyperactivity as a very early functional impairment in AD transgenic mice and provides direct evidence that soluble Aβ is crucial for hippocampal hyperactivity. 相似文献
6.
Andrea Talacchi Aurel HasanbelliuTeresa Fasano Massimo Gerosa 《Clinical neurology and neurosurgery》2013
Objective
Posterior gyrus cinguli tumors are a well-defined group of tumors that pose considerable challenges in creating surgical access and manipulating adjacent eloquent areas (visual and motor). Here we report our 5-year experience in the surgical treatment of these tumors and describe tumor characteristics, surgical steps, critical aspects, and prognostic factors.Methods
This series comprises 37 patients operated on for glioma (high-grade in 28, low-grade in 9), often presenting with motor impairment (n = 20), intracranial hypertension (n = 15), seizures (n = 11), and/or hemianopia (n = 9). Preoperative assessment was performed with magnetic resonance imaging. Half of the tumors were more than 4 cm in size, and the majority presented secondary extension into the fronto-parieto-occipital area, the temporo-mesial area, and/or the corpus callosum. Positioning and assisted surgery were optimized in each patient based on preoperative planning.Results
The ipsilateral interhemispheric approach was elected in all cases. Tumor size and extension were significantly associated with the degree of tumor removal. Total removal was achieved in 25 patients (65%); 4 (10%) had persistent morbidity (visual or motor deficits). The occurrence of local and systemic complications was negligible.Conclusions
Surgical treatment of posterior gyrus cinguli tumors can be safely approached via the interhemispheric route as it permits several beneficial operative maneuvers in selected cases. 相似文献7.
Aurel Popa Wagner Lieselotte Popa Wagner Eugenia Psarrou 《Age (Dordrecht, Netherlands)》1982,5(4):113-117
The possible changes in rRNA amounts in the spleens of immunized and non-immunized rats during aging were investigated.
The cytoplasmic RNA was extracted from intact spleens or spleen cell suspensions and 28So/ 18So, 28Sy/18Sy, 28So/28Sy, 18So/18Sy ratios were calculated, the most significant change (P < 0.01) occurring at the level of 28So/28Sy ratio; i.e., there was a six-fold increase in the ratio of 28S rRNA in old rats as compared to young rats suggesting a preferential
digestion of 26S subunit by neutral and alkaline RNAase whose activities were found to decrease in old non-immunized rats.
In immunized rats the situation was different, as there was a considerable decrease (over twenty fold) in rRNA from old animals
as compared to young ones, the most significant results being obtained with spleen cell suspensions.
As age-related changes in the immune system begin at the time of sexual maturity, we propose the use of rRNA as a marker of
rat senescence. 相似文献
8.
9.
Constantin Aurel Wauschkuhn Jochen Schwarz Ulf Boekeler Reinhard Bittner 《Surgical endoscopy》2010,24(12):3026-3030
Background
Advantages and disadvantages of open and endoscopic hernia surgery are still being discussed. Until now there has been no study that evaluated the advantages and disadvantages of bilateral hernia repair in a large number of patients. 相似文献10.
Badea I Moja D Tudose A Stoicescu D 《Journal of pharmaceutical and biomedical analysis》2002,30(4):1371-1378
A first derivative spectrometric method has been developed for the determination of the 5-fluorouracil and N1(2'-furanidyl)uracil related substances and degradation products of tegafur. The wavelengths selected for the determination of 5-fluorouracil and N1(2'-furanidyl)uracil were 298 and 288 nm, respectively. At this wavelength, the calibration graphs between the amplitude of the signals and the concentration of each compound were linear up to 24.75 mg l(-1) for 5-fluorouracil and up to 20.20 mg l(-1) for N1(2'-furanidyl)uracil. The detection limits were 0.40 and 0.050 mg l(-1) for 5-fluorouracil and N1(2'-furanidyl)uracil, respectively. The method is simple and rapid and does not require any preliminary treatment of the sample. The method was validated. 相似文献