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Jared Liu Hsin-Wen Chang Zhi-Ming Huang Mio Nakamura Sahil Sekhon Richard Ahn Priscila Munoz-Sandoval Shrishti Bhattarai Kristen M. Beck Isabelle M. Sanchez Eric Yang Mariela Pauli Sarah T. Arron Wai-Ping Fung-Leung Ernesto Munoz Xuejun Liu Tina Bhutani Jeffrey North Wilson Liao 《The Journal of allergy and clinical immunology》2021,147(6):2370-2380
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Lorcan P. McGarvey Claire A. Butler Susan Stokesberry Liam Polley Stephen McQuaid Hani’ah Abdullah Sadaf Ashraf Mary K. McGahon Tim M. Curtis Joe Arron David Choy Tim J. Warke Peter Bradding Madeleine Ennis Alexander Zholos Richard W. Costello Liam G. Heaney 《The Journal of allergy and clinical immunology》2014
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Recommendations for Solid Organ Transplantation for Transplant Candidates With a Pretransplant Diagnosis of Cutaneous Squamous Cell Carcinoma,Merkel Cell Carcinoma and Melanoma: A Consensus Opinion From the International Transplant Skin Cancer Collaborative (ITSCC)
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Sathish Paramasivan Ahmed Bassiouni Arron Shiffer Matthew R. Dillon Emily K. Cope Clare Cooksley Mahnaz Ramezanpour Sophia Moraitis Mohammad Javed Ali Benjamin Bleier Claudio Callejas Marjolein E. Cornet Richard G. Douglas Daniel Dutra Christos Georgalas Richard J. Harvey Peter H. Hwang Amber U. Luong Rodney J. Schlosser Pongsakorn Tantilipikorn Marc A. Tewfik Sarah Vreugde Peter-John Wormald J. Gregory Caporaso Alkis J. Psaltis 《Allergy》2020,75(8):2037-2049
The sinonasal microbiome remains poorly defined, with our current knowledge based on a few cohort studies whose findings are inconsistent. Furthermore, the variability of the sinus microbiome across geographical divides remains unexplored. We characterize the sinonasal microbiome and its geographical variations in both health and disease using 16S rRNA gene sequencing of 410 individuals from across the world. Although the sinus microbial ecology is highly variable between individuals, we identify a core microbiome comprised of Corynebacterium, Staphylococcus, Streptococcus, Haemophilus and Moraxella species in both healthy and chronic rhinosinusitis (CRS) cohorts. Corynebacterium (mean relative abundance = 44.02%) and Staphylococcus (mean relative abundance = 27.34%) appear particularly dominant in the majority of patients sampled. Amongst patients suffering from CRS with nasal polyps, a statistically significant reduction in relative abundance of Corynebacterium (40.29% vs 50.43%; P = .02) was identified. Despite some measured differences in microbiome composition and diversity between some of the participating centres in our cohort, these differences would not alter the general pattern of core organisms described. Nevertheless, atypical or unusual organisms reported in short-read amplicon sequencing studies and that are not part of the core microbiome should be interpreted with caution. The delineation of the sinonasal microbiome and standardized methodology described within our study will enable further characterization and translational application of the sinus microbiota. 相似文献
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