全文获取类型
收费全文 | 655篇 |
免费 | 49篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 54篇 |
妇产科学 | 6篇 |
基础医学 | 116篇 |
口腔科学 | 13篇 |
临床医学 | 47篇 |
内科学 | 101篇 |
皮肤病学 | 8篇 |
神经病学 | 22篇 |
特种医学 | 65篇 |
外科学 | 51篇 |
综合类 | 87篇 |
预防医学 | 59篇 |
眼科学 | 12篇 |
药学 | 46篇 |
中国医学 | 1篇 |
肿瘤学 | 21篇 |
出版年
2021年 | 3篇 |
2020年 | 4篇 |
2019年 | 13篇 |
2018年 | 10篇 |
2017年 | 8篇 |
2016年 | 6篇 |
2015年 | 12篇 |
2014年 | 16篇 |
2013年 | 18篇 |
2012年 | 26篇 |
2011年 | 32篇 |
2010年 | 29篇 |
2009年 | 38篇 |
2008年 | 30篇 |
2007年 | 32篇 |
2006年 | 29篇 |
2005年 | 22篇 |
2004年 | 18篇 |
2003年 | 18篇 |
2002年 | 10篇 |
2001年 | 14篇 |
2000年 | 13篇 |
1999年 | 25篇 |
1998年 | 37篇 |
1997年 | 20篇 |
1996年 | 28篇 |
1995年 | 13篇 |
1994年 | 26篇 |
1993年 | 14篇 |
1992年 | 4篇 |
1991年 | 6篇 |
1990年 | 5篇 |
1989年 | 8篇 |
1988年 | 10篇 |
1987年 | 4篇 |
1986年 | 3篇 |
1985年 | 9篇 |
1984年 | 9篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1980年 | 7篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1977年 | 13篇 |
1976年 | 11篇 |
1975年 | 10篇 |
1967年 | 7篇 |
1937年 | 2篇 |
1934年 | 2篇 |
排序方式: 共有710条查询结果,搜索用时 46 毫秒
1.
HUGH F. MOLLOY F.A.C.D. ERIC LAMONT-GREGORY M.SC. CHRIS IDZIKOWSKI PH.D. F.B.PS.S. TERENCE J. RYAN D.M. F.R.C.P. 《International journal of dermatology》1993,32(9):668-672
Background. Extensive questioning of patients with a wide variety of skin disorders led to the impression that nocturnal overheating was probably an important factor in the initiation and the perpetuation of many skin disorders. Methods. In order to test the hypothesis, 12 “clean-skinned” subjects (6M/6F) aged 18 to 45 years were monitored electronically every 30 seconds during an 8 hour sleep period (2300 to 0700 hours), sleeping under a standard 10 tog duvet. Results. All the subjects were too hot by 3 to 4°C. All showed changes in their EEG patterns with reduced REM sleep, increased awakenings, and all showed changes in their sleep stage patterns. In addition, they all showed evidence of increased sweating in the “heat-sink” area. Conclusions. The mechanisms where by such changes could be implicated in the precipitation and perpetuation of skin disease are discussed. “Lifestyle” modification as a very effective, noninvasive, therapeutic regime is recommended. Further research along these lines would probably be very valuable and instructive. 相似文献
2.
3.
4.
5.
Variants of B cell lymphoma 6 (BCL6) and marked atopy 总被引:3,自引:0,他引:3
Chaker N Adra PS Gao XQ Mao Beverly W Baron S. Pauker T. Miki T. Shirakawa JM Hopkin 《Clinical genetics》1998,54(4):362-364
6.
Mars F Archambault PS Feldman AG 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2003,150(4):515-519
Recent studies have shown that the hand-pointing movements within arm's reach remain invariant whether the trunk is recruited
or not or its motion is unexpectedly prevented. This suggests the presence of compensatory arm-trunk coordination minimizing
the deflections of the hand from the intended trajectory. It has been postulated that vestibular signals elicited by the trunk
motion and transmitted to the arm motor system play a major role in the compensation. One prediction of this hypothesis is
that vestibular stimulation should influence arm posture and movement during reaching. It has been demonstrated that galvanic
vestibular stimulation (GVS) can influence the direction of pointing movements when body motion is restrained. In the present
study, we analyzed the effects of GVS on trunk-assisted pointing movements. Subjects either moved the hand to a target or
maintained a steady-state posture near the target, while moving the trunk forward with the eyes closed. When GVS was applied,
the final position of the hand was deviated in the lateral and sagittal direction in both tasks. This was the result of two
independent effects: a deviation of the trunk trajectory and a modification of the arm position relative to the trunk. Thus,
the vestibular system might be directly involved not only in the control of trunk motion but also in the arm-trunk coordination
during trunk-assisted reaching movements.
Electronic Publication 相似文献
7.
8.
Mikko?PS?AresEmail author Maria?Stollenwerk Anneli?Olsson Bengt?Kallin Stefan?Jovinge Jan?Nilsson 《BMC immunology》2002,3(1):13
Background
Inflammation and immune responses are considered to be very important in the pathogenesis of atherosclerosis. Lipid accumulation in macrophages of the arterial intima is a characteristic feature of atherosclerosis which can influence the inflammatory potential of macrophages. We studied the effects of lipid loading on the regulation of TNF expression in human monocyte-derived macrophages. 相似文献9.
Mahadevaiah SK; Odorisio T; Elliott DJ; Rattigan A; Szot M; Laval SH; Washburn LL; McCarrey JR; Cattanach BM; Lovell-Badge R; Burgoyne PS 《Human molecular genetics》1998,7(4):715-727
An RNA-binding motif (RBM) gene family has been identified on the human Y
chromosome that maps to the same deletion interval as the 'azoospermia
factor' (AZF). We have identified the homologous gene family (Rbm) on the
mouse Y with a view to investigating the proposal that this gene family
plays a role in spermatogenesis. At least 25 and probably >50 copies of
Rbm are present on the mouse Y chromosome short arm located between Sry and
the centromere. As in the human, a role in spermatogenesis is indicated by
a germ cell-specific pattern of expression in the testis, but there are
distinct differences in the pattern of expression between the two species.
Mice carrying the deletion Yd1, that maps to the proximal Y short arm, are
female due to a position effect resulting in non-expression of Sry ;
sex-reversing such mice with an Sry transgene produces males with a high
incidence of abnormal sperm, making this the third deletion interval on the
mouse Y that affects some aspect of spermatogenesis. Most of the copies of
Rbm map to this deletion interval, and the Yd1males have markedly reduced
Rbm expression, suggesting that RBM deficiency may be responsible for, or
contribute to, the abnormal sperm development. In man, deletion of the
functional copies of RBM is associated with meiotic arrest rather than
sperm anomalies; however, the different effects of deletion are consistent
with the differences in expression between the two species.
相似文献
10.
Distribution of mutations in the PEX gene in families with X-linked hypophosphataemic rickets (HYP) 总被引:8,自引:0,他引:8
Rowe PS; Oudet CL; Francis F; Sinding C; Pannetier S; Econs MJ; Strom TM; Meitinger T; Garabedian M; David A; Macher MA; Questiaux E; Popowska E; Pronicka E; Read AP; Mokrzycki A; Glorieux FH; Drezner MK; Hanauer A; Lehrach H; Goulding JN; O'Riordan JL 《Human molecular genetics》1997,6(4):539-549
Mutations in the PEX gene at Xp22.1 (phosphate-regulating gene with
homologies to endopeptidases, on the X-chromosome), are responsible for
X-linked hypophosphataemic rickets (HYP). Homology of PEX to the M13 family
of Zn2+ metallopeptidases which include neprilysin (NEP) as prototype, has
raised important questions regarding PEX function at the molecular level.
The aim of this study was to analyse 99 HYP families for PEX gene
mutations, and to correlate predicted changes in the protein structure with
Zn2+ metallopeptidase gene function. Primers flanking 22 characterised
exons were used to amplify DNA by PCR, and SSCP was then used to screen for
mutations. Deletions, insertions, nonsense mutations, stop codons and
splice mutations occurred in 83% of families screened for in all 22 exons,
and 51% of a separate set of families screened in 17 PEX gene exons.
Missense mutations in four regions of the gene were informative regarding
function, with one mutation in the Zn2+-binding site predicted to alter
substrate enzyme interaction and catalysis. Computer analysis of the
remaining mutations predicted changes in secondary structure,
N-glycosylation, protein phosphorylation and catalytic site molecular
structure. The wide range of mutations that align with regions required for
protease activity in NEP suggests that PEX also functions as a protease,
and may act by processing factor(s) involved in bone mineral metabolism.
相似文献