全文获取类型
收费全文 | 373篇 |
免费 | 17篇 |
专业分类
儿科学 | 16篇 |
妇产科学 | 5篇 |
基础医学 | 63篇 |
口腔科学 | 1篇 |
临床医学 | 46篇 |
内科学 | 89篇 |
皮肤病学 | 5篇 |
神经病学 | 58篇 |
特种医学 | 22篇 |
外科学 | 22篇 |
预防医学 | 40篇 |
药学 | 7篇 |
肿瘤学 | 16篇 |
出版年
2023年 | 5篇 |
2022年 | 6篇 |
2021年 | 15篇 |
2020年 | 11篇 |
2019年 | 20篇 |
2018年 | 7篇 |
2017年 | 7篇 |
2016年 | 15篇 |
2015年 | 11篇 |
2014年 | 18篇 |
2013年 | 20篇 |
2012年 | 41篇 |
2011年 | 39篇 |
2010年 | 12篇 |
2009年 | 17篇 |
2008年 | 22篇 |
2007年 | 24篇 |
2006年 | 17篇 |
2005年 | 22篇 |
2004年 | 17篇 |
2003年 | 17篇 |
2002年 | 12篇 |
2001年 | 1篇 |
1999年 | 1篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1986年 | 2篇 |
排序方式: 共有390条查询结果,搜索用时 15 毫秒
1.
Annet Lievense Sita Bierma-Zeinstra Boris Schouten Arthur Bohnen Jan Verhaar Bart Koes 《The British journal of general practice》2005,55(512):199-204
BACKGROUND: Trochanteric pain is the second most important diagnosis of hip problems presenting in primary care, but its incidence and prognosis in this context is largely unknown. AIM: To determine the 1- and 5-year prognoses of trochanteric pain and the predictive variables for consistent complaints. DESIGN OF THE STUDY: Retrospective cohort study. SETTING: One hundred and sixty-four patients (mean age = 55 years, 80% female) with incidental trochanteric pain in the years 1996 or 2000 were asked in 2001 for past and present symptoms of trochanteric pain. Therapeutic interventions, demographic factors and comorbidity were also investigated. METHOD: The databases of 39 GPs were screened in order to identify all incident cases with a suspicion of trochanteric pain in the years 1996 or 2000. These cases were sent a questionnaire. RESULTS: The incidence of trochanteric pain in primary care is 1.8 patients per 1000 per year. After 1 year at least 36% still suffered from trochanteric pain, and after 5 years this was 29%. Patients with osteoarthritis (OA) in the lower limbs had a 4.8-fold risk of persistent symptoms after 1 year, as compared to patients without OA. Patients who had received a corticosteroid injection had a 2.7-fold chance of recovery after 5 years, as compared with patients who had not received an injection. CONCLUSION: Trochanteric pain is shown to be a chronic disease in a substantial number of patients. The disorder is associated with much impairment when conducting daily activities. 相似文献
2.
The influence of pregnancy and gender on perivascular innervation of rat posterior cerebral arteries
Aukes AM Bishop N Godfrey J Cipolla MJ 《Reproductive sciences (Thousand Oaks, Calif.)》2008,15(4):411-419
The authors investigated the influence of pregnancy and gender on the density of trigeminal and sympathetic perivascular nerves in posterior cerebral arteries (PCA) and the reactivity to norepinephrine and calcitonin gene-related peptide (CGRP). PCAs were isolated from nonpregnant, late-pregnant, postpartum, and male rats, mounted and pressurized on an arteriograph chamber to obtain concentration-response curves to norepinephrine and CGRP. Arteries were immunostained for CGRP-, tyrosine hydroxylase-, and protein gene product 9.5 (PGP 9.5)-containing perivascular nerves, and nerve density was determined morphologically. Pregnancy had a trophic effect on trigeminal perivascular innervation (P < .01 vs male); however, this was not accompanied by a change in reactivity to CGRP. Sympathetic and PGP 9.5 nerve densities were not altered by pregnancy or gender, and there were no differences in reactivity to norepinephrine. Together, these results suggest that the increase in trigeminal innervation during pregnancy is more related to nociception than in controlling resting cerebral blood flow. 相似文献
3.
Pragney Deme Leah H. Rubin Danyang Yu Yanxun Xu Gertrude Nakigozi Noeline Nakasujja Aggrey Anok Alice Kisakye Thomas C. Quinn Steven J. Reynolds Richard Mayanja James Batte Maria J. Wawer Ned C. Sacktor Deanna Saylor Norman J. Haughey 《Viruses》2022,14(6)
Background: HIV infection results in immunometabolic reprogramming. While we are beginning to understand how this metabolic reprogramming regulates the immune response to HIV infection, we do not currently understand the impact of ART on immunometabolism in people with HIV (PWH). Methods: Serum obtained from HIV-infected (n = 278) and geographically matched HIV seronegative control subjects (n = 300) from Rakai Uganda were used in this study. Serum was obtained before and ~2 years following the initiation of ART from HIV-infected individuals. We conducted metabolomics profiling of the serum and focused our analysis on metabolic substrates and pathways assocaited with immunometabolism. Results: HIV infection was associated with metabolic adaptations that implicated hyperactive glycolysis, enhanced formation of lactate, increased activity of the pentose phosphate pathway (PPP), decreased β-oxidation of long-chain fatty acids, increased utilization of medium-chain fatty acids, and enhanced amino acid catabolism. Following ART, serum levels of ketone bodies, carnitine, and amino acid metabolism were normalized, however glycolysis, PPP, lactate production, and β-oxidation of long-chain fatty acids remained abnormal. Conclusion: Our findings suggest that HIV infection is associated with an increased immunometabolic demand that is satisfied through the utilization of alternative energetic substrates, including fatty acids and amino acids. ART alone was insufficient to completely restore this metabolic reprogramming to HIV infection, suggesting that a sustained impairment of immunometabolism may contribute to chronic immune activation and comorbid conditions in virally suppressed PWH. 相似文献
4.
José de Jager Roos van Greevenbroek Annet Nugter Jim van Os 《Community mental health journal》2018,54(7):1082-1088
This qualitative study aims to explore the difficulties people with a psychotic disorder have in sexual expression, and associated determinants. Twenty-eight semi-structured interviews were conducted and analyzed using the Grounded Theory method. Almost all participants experienced unfulfilled needs in sexual expression. These unfulfilled needs were associated with a range of factors, including antipsychotic medication, psychotic symptoms, sexual abuse, social skills and stigma, all of which may converge on a pathway involving (sexual) self-esteem. Further research is required to better understand the role of self-esteem in relation to sexual needs and expression in people with psychotic disorders. 相似文献
5.
6.
7.
Vecchio Alyssa Nakigozi Gertrude Nakasujja Noeline Kisakye Alice Batte James Mayanja Richard Anok Aggrey Robertson Kevin Wawer Maria J. Sacktor Ned Rubin Leah H. Saylor Deanna 《Journal of neurovirology》2021,27(3):487-492
Journal of NeuroVirology - We investigated the prevalence and risk factors for frailty among people with HIV (PWH) in rural Uganda (n = 55, 47% male, mean age 44 years).... 相似文献
8.
9.
10.
Noah Kiwanuka Ali Ssetaala Juliet Mpendo Matthias Wambuzi Annet Nanvubya Simon Sigirenda Annet Nalutaaya Paul Kato Leslie Nielsen Pontiano Kaleebu Josephine Nalusiba Nelson K Sewankambo 《Journal of the International AIDS Society》2013,16(1)