全文获取类型
收费全文 | 193篇 |
免费 | 16篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 8篇 |
妇产科学 | 1篇 |
基础医学 | 31篇 |
口腔科学 | 2篇 |
临床医学 | 9篇 |
内科学 | 33篇 |
皮肤病学 | 2篇 |
神经病学 | 44篇 |
特种医学 | 5篇 |
外科学 | 16篇 |
预防医学 | 18篇 |
眼科学 | 3篇 |
药学 | 7篇 |
肿瘤学 | 28篇 |
出版年
2023年 | 1篇 |
2022年 | 5篇 |
2021年 | 9篇 |
2020年 | 4篇 |
2019年 | 11篇 |
2018年 | 7篇 |
2017年 | 6篇 |
2016年 | 6篇 |
2015年 | 5篇 |
2014年 | 9篇 |
2013年 | 13篇 |
2012年 | 15篇 |
2011年 | 11篇 |
2010年 | 6篇 |
2009年 | 13篇 |
2008年 | 7篇 |
2007年 | 12篇 |
2006年 | 8篇 |
2005年 | 3篇 |
2004年 | 3篇 |
2003年 | 7篇 |
2002年 | 12篇 |
2001年 | 3篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有209条查询结果,搜索用时 15 毫秒
1.
Liviana Da Dalt Silvia Callegaro Silvia Carraro Barbara Andreola Massimo Corradi Eugenio Baraldi 《Pediatric allergy and immunology》2007,18(2):100-104
Respiratory syncytial virus (RSV) bronchiolitis is a very common infection in infants and, after the acute phase, a number of patients develop a reactive airway disease that lasts for years. Although the pathogenesis of the lung damage after RSV bronchiolitis is still largely unknown, previous studies suggest that leukotrienes may play an active part in it. The aim of this study was to measure leukotriene levels in the nasal lavage fluid (NLF) collected in infants during RSV bronchiolitis and 1 month later. Cysteinyl leukotrienes (Cys-LTs) and leukotriene B(4) (LTB(4)) were measured in the NLF of 22 infants with their first episode of RSV bronchiolitis and 16 healthy infants. A second NLF sample was collected to measure leukotriene levels 1 month after the acute disease. NLF Cys-LT levels were significantly higher in infants with RSV bronchiolitis than in healthy controls [950 pg/ml (285.5-2155.9) vs. 110.5 pg/ml (66.5-451.3), p = 0.01], and they remained so a month after the acute infection (p = 0.02). A subanalysis showed no difference in Cys-LTs concentrations, either between bronchiolitis infants with and without a family history of atopy, or between those with and without passive exposure to cigarette smoke. No significant difference was found between the LTB(4) levels measured in the bronchiolitis cases and the control children. Cys-LTs are significantly increased in the NLF of infants with acute RSV bronchiolitis, and remain so at 1-month follow-up, suggesting a possible role of these eicosanoids in the pathogenesis of the disease. 相似文献
2.
Nonunion fracture healing: Evaluation of effectiveness of demineralized bone matrix and mesenchymal stem cells in a novel sheep bone nonunion model
下载免费PDF全文
![点击此处可从《Journal of tissue engineering and regenerative medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Barbara Dozza Francesca Salamanna Massimiliano Baleani Gianluca Giavaresi Annapaola Parrilli Lorenzo Zani Enrico Lucarelli Lucia Martini Milena Fini Davide Maria Donati 《Journal of tissue engineering and regenerative medicine》2018,12(9):1972-1985
Nonunion treatment has a high rate of success, although recalcitrant nonunion may determine the need for amputation. Therefore, new treatment options are continuously investigated in order to further reduce the risk of nonunion recurrence. This study aimed to (a) develop a new large animal model for bone atrophic nonunion and (b) compare the efficacy of demineralized bone matrix (DBM) and DBM in combination with mesenchymal stem cells (MSC) in the new nonunion model. The new model consists of a noncritical, full‐thickness segmental defect created in the sheep tibia, stabilized by an intramedullary nail, and involves the creation of a locally impaired blood supply achieved through periosteum excision and electrocauterization of the stump ends. Six weeks after defect creation, lack of hard tissue callus and established nonunion was observed in all operated tibiae both by radiographic and clinical evaluation. Nonunion was treated with allogeneic DBM or autologous MSC cultivated on DBM particles (DBM + MSC) for 1 day before implantation. Twelve weeks after treatment, radiographic, microtomographic, histologic, and histomorphometric analysis showed the formation of bone callus in DBM group, whereas the fracture healing appeared at an early stage in DBM + MSC group. Torsional strength and stiffness of the DBM group appeared higher than those of DBM + MSC group, although the differences were not statistically significant. In conclusion, a new sheep bone nonunion model resembling the complexity of the clinical condition was developed. DBM is an effective option for nonunion treatment, whereas MSC do not improve the healing process when cultivated on DBM particles before implantation. 相似文献
3.
Rosso R Di Biagio A Maggiolo F Nulvesu L Callegaro AP Taramasso L Bruzzone B Viscoli C 《AIDS care》2012,24(1):54-58
The choice of an antiretroviral regimen can often impact on adherence, treatment satisfaction and therefore influence on clinical outcome. These concerns are particularly true in adolescents. In this setting, adherence is usually affected by multifactor events and biopsychosocial factors, which connect and changeover time. We evaluated the effect of a switch to a single-pill fixed-dose regimen on patient-reported outcomes, virologic and immunologic outcomes, and safety in a cohort of adolescents with perinatal HIV-1 infection. In addition, we evaluated the effect on low-level residual HIV-RNA. An open-label, non-randomised study was performed: 12 adolescents with a confirmed viremia <50 copies/mL treated with lamivudine or emtricitabine, tenofovir and efavirenz were switched to one-pill fixed-dose regimen of emtricitabine/tenofovir/efavirenz. At the end of follow-up, the new regimen was associated with improvements in treatment satisfaction, HIV-symptoms, whereas adherence remained high. No immunological or virological significative changes were observed. No side-effects were registered. Moreover, the low-level residual HIV-RNA was <3 copie/mL in all patients. One-pill fixed-dose regimen is an added value that favours adherence, reduces HIV-symptoms, improves patients' satisfaction and could better control of HIV-RNA in adolescents, too. 相似文献
4.
5.
Tseng William W. Swallow Carol J. Strauss Dirk C. Bonvalot Sylvie Rutkowski Piotr Ford Samuel J. Gonzalez Ricardo J. Gladdy Rebecca A. Gyorki David E. Fairweather Mark Lee Kyo Won Albertsmeier Markus van Houdt Winan J. Fau Magalie Nessim Carolyn Grignani Giovanni Cardona Kenneth Quagliuolo Vittorio Grignol Valerie Farma Jeffrey M. Pennacchioli Elisabetta Fiore Marco Hayes Andrew Tzanis Dimitri Skoczylas Jacek Almond Max L. Mullinax John E. Johnston Wendy Snow Hayden Haas Rick L. Callegaro Dario Smith Myles J. Bouhadiba Toufik Desai Anant Voss Rachel Sanfilippo Roberta Jones Robin L. Baldini Elizabeth H. Wagner Andrew J. Catton Charles N. Stacchiotti Silvia Thway Khin Roland Christina L. Raut Chandrajit P. Gronchi Alessandro 《Annals of surgical oncology》2022,29(12):7335-7348
Annals of Surgical Oncology - Surgery is the mainstay of treatment for retroperitoneal sarcoma (RPS), but local recurrence is common. Biologic behavior and recurrence patterns differ significantly... 相似文献
6.
Vito Leonardo Miniello Maria Felicia Faienza Pietro Scicchitano Francesca Cortese Michele Gesualdo Annapaola Zito Marina Basile Pasquale Recchia Domenico Leogrande Domenico Viola Paola Giordano Marco Matteo Ciccone 《International journal of cardiology》2014
Aims
Insulin resistance (IR) impairs cellular response to insulin due to a dysfunction in glucose metabolism, associated with an increased cardiovascular risk. The aim of our study was to investigate the relationship among homeostasis model assessment index (HOMA index), endothelial function and vascular morphology in order to better stratify cardiovascular risk in children and adolescents.Methods
A total of 150 children and adolescents (55 pre-pubertal, mean age 10.4 ± 3.1 years) were enrolled. Anthropometric [body mass index (BMI), waist circumference (WC)], laboratory [blood lipids, inflammatory markers, insulinemia, glycemia], HOMA index and ultrasound parameters [flow-mediated dilatation (FMD), common carotid intima–media thickness (cIMT) and antero-posterior diameter of infra-renal abdominal aorta (APAO)] were assessed.Results
cIMT was positively related to age (r = 0.274, p < 0.01), BMI (r = 0.318, p < 0.01), WC (r = 0.315, p < 0.01) and triglycerides (r = 0.230, p < 0.01). APAO measurements showed a linear positive correlation with age (r = 0.435, p < 0.01), BMI (r = 0.505, p < 0.01), WC (r = 0.487, p < 0.01), triglycerides (r = 0.280, p < 0.01), C-reactive protein (r = 0.209, p < 0.05), fasting insulin (r = 0.378, p < 0.01) and HOMA index (r = 0.345, p < 0.01). FMD was inversely related to age (r = − 0.251, p < 0.01), rough BMI (r = − 0.318, p < 0.01), WC (r = − 0.340, p < 0.01), fasting insulin (r = − 0.281, p < 0.01) and HOMA index (r = − 0.282, p < 0.01). Multiple regression analysis found no influence of HOMA index on APAO and cIMT. HOMA index was an independent predictor for brachial artery FMD worsening after the statistical adjustment.Conclusion
HOMA index increase induced a worsening in endothelial function since childhood. 相似文献7.
Giovana Dorneles Callegaro Higashi Alacoque Lorenzini Erdmann 《Revista latino-americana de enfermagem》2014,22(2):269-276
Objective
to understand the meanings of the collegiate deliberations attributed by its members on an undergraduate nursing course.Method
Grounded Theory, interviews being held with 30 participants, making up 4 sample groups, between January and June 2012, in a public higher education institution.Result
5 categories emerged, indicating the phenomenon and weaving the paradigmatic model: Understanding the experience of the complex relationships and interactions in the deliberations of collegiate management in nursing: intertwining divergences, convergences, dialogs, collectivities and diversities. This deliberative process presents various meanings involving discussion, and divergent, convergent and complementary positions, through dialog, commitment and negotiation.Conclusion
the deliberations in the collegiate of nursing, intertwining dialogs, collectivities and diversities, mold the complex relational fabrics. 相似文献8.
Juliane Callegaro Borsa Bruno Figueiredo Damásio Denise Ruschel Bandeira Paola Gremigni 《Child psychiatry and human development》2013,44(6):766-776
This study examines measurement invariance, reliability and scores differences of the Peer Aggressive and Reactive Behaviors Questionnaire (PARB-Q) across Italian and Brazilian children, gender and age. Participants were 587 Italian and 727 Brazilian children, aged 7–13 years from 12 elementary schools. The PARB-Q is a brief self-report instrument composed by two scales that assess aggressive behavior and reactions to peer aggression. Multigroup confirmatory factor analyses indicated full measurement invariance of the PARB-Q across groups based on country, gender and age, providing support for the unidimensionality of the first scale (direct peer aggression, PA) and a 3-factor model of the second scale (reactive aggression, RA; seeking teacher support, STS; internalizing reaction, IR). Reliability indices were good for all factors. Italian children reported a higher frequency of PA and a lower frequency of IR than the Brazilian children. Boys scored higher than girls on PA and RA, while girls scored higher than boys on STS and IR. Younger children reported a lower frequency of PA and a higher frequency of STS than older children. Results provide support for structure validity and reliability of the PARB-Q in two countries and information on differences related to gender, age and culture in peer relationships in elementary school. 相似文献
9.
10.
Ulrike Benninghoff Federica Cattaneo Alessandro Aiuti Alberto Flores-D'Arcais Carlo Gelmetti Matteo Viscardi Luciano Callegaro Massimiliano Mirolo Alessandro Ambrosi Maria Grazia Roncarolo Rosa Bacchetta 《Pediatric allergy and immunology》2008,19(6):564-568
We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug. 相似文献