首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   53988篇
  免费   3654篇
  国内免费   260篇
耳鼻咽喉   525篇
儿科学   1921篇
妇产科学   1374篇
基础医学   8048篇
口腔科学   902篇
临床医学   5180篇
内科学   12187篇
皮肤病学   1177篇
神经病学   5918篇
特种医学   1181篇
外科学   4394篇
综合类   301篇
现状与发展   1篇
一般理论   43篇
预防医学   5048篇
眼科学   869篇
药学   4081篇
中国医学   136篇
肿瘤学   4616篇
  2024年   91篇
  2023年   683篇
  2022年   1442篇
  2021年   2429篇
  2020年   1402篇
  2019年   1793篇
  2018年   1979篇
  2017年   1599篇
  2016年   1762篇
  2015年   1908篇
  2014年   2474篇
  2013年   3118篇
  2012年   4580篇
  2011年   4584篇
  2010年   2434篇
  2009年   2071篇
  2008年   3456篇
  2007年   3449篇
  2006年   3119篇
  2005年   2842篇
  2004年   2626篇
  2003年   2345篇
  2002年   2116篇
  2001年   250篇
  2000年   193篇
  1999年   264篇
  1998年   339篇
  1997年   290篇
  1996年   194篇
  1995年   186篇
  1994年   186篇
  1993年   146篇
  1992年   113篇
  1991年   94篇
  1990年   76篇
  1989年   86篇
  1988年   77篇
  1987年   73篇
  1986年   69篇
  1985年   69篇
  1984年   92篇
  1983年   75篇
  1982年   80篇
  1981年   71篇
  1980年   64篇
  1979年   36篇
  1978年   37篇
  1977年   39篇
  1976年   26篇
  1974年   23篇
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Journal of Behavioral Medicine - Evidence supports the use of graphic warnings to educate the public about the health harms of smoking and suggests warnings eliciting negative emotional responses...  相似文献   
2.
Forgiveness has been found one substantial element in the recovery for women survivors from intimate partner violence following the termination of the abusive relationship. To further investigate the details of forgiveness in this specific context, the present study explored the process of forgiveness using grounded theory. In-depth and semi-structured interviews were conducted with 25 Chinese women survivors of IPV. The findings suggest that forgiveness is a strength-based process including empowerment, transformation, and integration phases. In the empowerment phase, survivors obtain strength at the intrapersonal, behavioural, and interpersonal levels. In the transformation phase, survivors complete cognitive transformation for their IPV experiences and emotional transformation towards former partners. In the integration phase, survivors—now freed from the past—reflect upon and apply the changes they have undergone. Two trajectories in the process were found. One trajectory is going through stages sequentially and the other trajectory is experiencing back and forth between empowerment and transformation stages before moving into the integration stage. The study's findings broaden our knowledge of the strength-based forgiveness process that women survivors of IPV undergo during recovery. Practitioners and policymakers could develop programmes and policies that support forgiveness by holistically facilitating their recovery and empowerment like assistance in dealing with life difficulties and promoting their reconnection with social networks. To improve the transferability and validity of the findings, the forgiveness of survivors of IPV could be explored in a diverse sample (e.g., survivors with low educational background or live in the rural area).  相似文献   
3.
4.
Abstract

Supporting patients in making informed healthcare decisions is a cornerstone of ethical medical practice. Surgeons frequently draw for and show images to patients when consenting them for operations but the value of this practice in informed decision-making is unclear. An audit was conducted in a General Surgery Department. 244 patients completed questionnaires on the value of visual materials when giving consent for surgery. The complexity of the operations was classified into “simple”, “moderate” or “complex”. 100% of patients felt they had given informed consent to surgery. 62% of patients received at least one form of visual material during the consenting process. All patients who received a drawing, and 99% of those provided with other images, valued these resources. Visual materials were considered more useful to patients when giving consent for moderate or complex operations than simple ones. Approximately one third of patients who did not receive visual materials would have appreciated these when making an informed decision. This research highlights the value of surgeons drawing for, and providing other visual resources to, their patients as part of the consent process. There is a role for further research and training materials in drawing skills for surgeons.  相似文献   
5.
6.
7.
8.
9.
10.

Background

Rosacea is a chronic inflammatory skin condition whose etiology has been linked to mast cells and the antimicrobial peptide cathelicidin LL-37. Individuals with refractory disease have demonstrated clinical benefit with periodic injections of onabotulinum toxin, but the mechanism of action is unknown.

Objectives

To investigate the molecular mechanism by which botulinum toxin improves rosacea lesions.

Methods

Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control. Mast cell degranulation was evaluated by β-hexosaminidase activity. Expression of botulinum toxin receptor Sv2 was measured by qPCR. The presence of SNAP-25 and VAMP2 was established by immunofluorescence. In vivo rosacea model was established by intradermally injecting LL-37 with or without onabotulinum toxin A pretreatment. Mast cell degranulation was assessed in vivo by histologic counts. Rosacea biomarkers were analyzed by qPCR of mouse skin sections.

Results

Onabotulinum toxin A and B inhibited compound 48/80-induced degranulation of both human and murine mast cells. Expression of Sv2 was established in mouse mast cells. Onabotulinum toxin A and B increased cleaved SNAP-25 and decreased VAMP2 staining in mast cells respectively. In mice, injection of onabotulinum toxin A significantly reduced LL-37-induced skin erythema, mast cell degranulation, and mRNA expression of rosacea biomarkers.

Conclusions

These findings suggest that onabotulinum toxin reduces rosacea-associated skin inflammation by directly inhibiting mast cell degranulation. Periodic applications of onabotulinum toxin may be an effective therapy for refractory rosacea and deserves further study.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号