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Sahana K.S. Prakash R.M. Saldanha Supriya Kushwah Anitha S. Prabhu 《The Indian journal of tuberculosis》2018,65(3):195-199
Introduction
In spite of having BCG vaccination and tuberculosis control program for the last 50 years, prevalence of tuberculosis continues to be high in India. Inadequate diagnostic methods, suboptimal treatment and monitoring, and the lack of vigilant reporting system are some of the contributing factors for the failure of TB control.Objectives
To know the current practices among local pediatricians regarding management of TB.Materials and methods
Field based cross sectional study. All the registered pediatricians who were practicing in Mangalore, (list – local IAP branch) were included in the study. A structured Questionnaire on signs and symptoms of TB, diagnosis, strategies adopted in treatment, MDR tuberculosis and reporting of cases to RNTCP was asked. Management practice standards according to the Updated National Guidelines for Pediatric Tuberculosis in India, 2012, RNTCP guidelines in consensus with IAP, latest at the time of the study.Results
50 pediatricians participated in the study with 62% having an attachment to the teaching institution. More than 50% identified all the symptoms of TB. 64% were sending chest X-ray, Mantoux test and gastric lavage/induced sputum examination for AFB to diagnose TB. 22% were not stressing for AFB examination. Still 16% told serological tests as one of the diagnostic modality. 52% were not aware about the diagnosis of latent TB. In 16% of their cases ATT was on a trial basis. Only 52% of the clinicians are adhering to updated national (RNTCP) guidelines. 30% felt still there are drawbacks in the current RNTCP guidelines. 72% knew the correct definition of MDR tuberculosis. But only 36% of them knew the diagnostic method (gene expert/CB NAAT) of confirming the MDR TB.Conclusion
Management practices are found to be still suboptimum. Better engagement of the private sector is urgently required to improve TB management practices and to prevent diagnostic delay and drug resistance. 相似文献3.
Jasmine Aliya G.V. Akila Durai Vanitha M. Anitha Rani Shriraam Vanishree V. Samya T. Gayathri Mahadevan Shriraam 《International journal of diabetes in developing countries.》2021,41(2):293-300
International Journal of Diabetes in Developing Countries - There is a huge burden of diabetes-related complications, both microvascular and macrovascular, in India. With the rising prevalence of... 相似文献
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Davis Victoria H. Nixon Stephanie A. Murphy Kathleen Cameron Cathy Bond Virginia A. Hanass-Hancock Jill Kimura Lauren Maimbolwa Margaret C. Menon J. Anitha Nekolaichuk Erica Solomon Patricia 《AIDS and behavior》2022,26(10):3386-3399
AIDS and Behavior - This scoping review assessed how the term ‘self-management’ (SM) is used in peer-reviewed literature describing HIV populations in low- and middle-income countries... 相似文献
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Kabundula Pelekelo P. Mbewe Esau G. Mwanza-Kabaghe Sylvia Birbeck Gretchen L. Mweemba Milimo Wang Bo Menon J. Anitha Bearden David R. Adams Heather R. 《AIDS and behavior》2022,26(10):3450-3450
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Chih-Kuang Chen Charles H. Jones Panagiotis Mistriotis Yun Yu Xiaoni Ma Anitha Ravikrishnan Ming Jiang Stelios T. Andreadis Blaine A. Pfeifer Chong Cheng 《Biomaterials》2013
Representing a new type of biodegradable cationic block copolymer, well-defined poly(ethylene glycol)-block-cationic polylactides (PEG-b-CPLAs) with tertiary amine-based cationic groups were synthesized by thiol-ene functionalization of an allyl-functionalized diblock precursor. Subsequently the application of PEG-b-CPLAs as biodegradable vectors for the delivery of plasmid DNAs (pDNAs) was investigated. Via the formation of PEG-b-CPLA:pDNA nanocomplexes by spontaneous electrostatic interaction, pDNAs encoding luciferase or enhanced green fluorescent protein were successfully delivered to four physiologically distinct cell lines (including macrophage, fibroblast, epithelial, and stem cell). Formulated nanocomplexes demonstrated high levels of transfection with low levels of cytotoxicity and hemolysis when compared to a positive control. Biophysical characterization of charge densities of nanocomplexes at various polymer:pDNA weight ratios revealed a positive correlation between surface charge and gene delivery. Nanocomplexes with high surface charge densities were utilized in an in vitro serum gene delivery inhibition assay, and effective gene delivery was observed despite high levels of serum. Overall, these results help to elucidate the influence of charge, size, and PEGylation of nanocomplexes upon the delivery of nucleic acids in physiologically relevant conditions. 相似文献
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Vasudevan Karthikeyan Naveen Gopi Chander Kuttae Viswanathan Anitha 《The Journal of prosthetic dentistry》2019,121(3):384-386
This article describes a method for managing xerostomia in edentulous patients with a newly developed salivary sensor. A micropressure sensor unit with a capsule to hold artificial salivary substitute was built into the dental prosthesis. This sensor prosthesis can help patients overcome mouth dryness, improves patient comfort, and aids in retention of the prosthesis. 相似文献