全文获取类型
收费全文 | 8413篇 |
免费 | 471篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 167篇 |
儿科学 | 377篇 |
妇产科学 | 174篇 |
基础医学 | 811篇 |
口腔科学 | 231篇 |
临床医学 | 594篇 |
内科学 | 1719篇 |
皮肤病学 | 109篇 |
神经病学 | 443篇 |
特种医学 | 255篇 |
外科学 | 1896篇 |
综合类 | 158篇 |
现状与发展 | 1篇 |
一般理论 | 5篇 |
预防医学 | 359篇 |
眼科学 | 149篇 |
药学 | 680篇 |
1篇 | |
中国医学 | 35篇 |
肿瘤学 | 750篇 |
出版年
2023年 | 50篇 |
2022年 | 97篇 |
2021年 | 234篇 |
2020年 | 129篇 |
2019年 | 176篇 |
2018年 | 210篇 |
2017年 | 181篇 |
2016年 | 206篇 |
2015年 | 283篇 |
2014年 | 375篇 |
2013年 | 429篇 |
2012年 | 664篇 |
2011年 | 730篇 |
2010年 | 437篇 |
2009年 | 377篇 |
2008年 | 547篇 |
2007年 | 569篇 |
2006年 | 530篇 |
2005年 | 535篇 |
2004年 | 442篇 |
2003年 | 403篇 |
2002年 | 372篇 |
2001年 | 112篇 |
2000年 | 79篇 |
1999年 | 73篇 |
1998年 | 58篇 |
1997年 | 62篇 |
1996年 | 40篇 |
1995年 | 35篇 |
1994年 | 43篇 |
1993年 | 36篇 |
1992年 | 38篇 |
1991年 | 42篇 |
1990年 | 36篇 |
1989年 | 34篇 |
1988年 | 20篇 |
1987年 | 17篇 |
1986年 | 17篇 |
1985年 | 9篇 |
1984年 | 17篇 |
1983年 | 17篇 |
1982年 | 16篇 |
1981年 | 17篇 |
1980年 | 9篇 |
1979年 | 10篇 |
1978年 | 10篇 |
1977年 | 10篇 |
1976年 | 12篇 |
1974年 | 11篇 |
1972年 | 12篇 |
排序方式: 共有8914条查询结果,搜索用时 15 毫秒
1.
2.
The antiproliferative, cytotoxic and apoptogenic activities of Bufo melanostictus (Indian common toad) skin extract (TSE) on U937 and K562 leukemic cell line has been investigated. TSE significantly (P<0.001) reduced the time-dependent cell proliferation and decreased MTT values in U937 and K562 cells. TSE (IC50 doses) suppressed the proliferating cell nuclear antigen expression in both the cells. It was demonstrated that, TSE (IC50 doses) primarily arrested the U937 and K562 cells at G1 phase of the cell cycle. Confocal microscopy showed the altered fragmented nuclei and apoptotic bodies formation in TSE (IC50 doses) treated U937 and K562 cells. Membrane blebbing, cell surface shrinkage and perforation were observed through scanning electron microscope. TSE-induced DNA fragmentation in U937 and K562 cells was reflected in single-cell gel electrophoresis. TSE significantly (P<0.001) increase the length-width ratio of DNA mass as compared to control in comet assay. The flow cytometric analysis of annexin-V binding to the cancer cells further supported the apoptotogenic activity of TSE. The effect of TSE on normal human peripheral blood mononuclear cells viability and cytotoxicity was studied in culture and found to be less cytotoxic than on the U937 and K562 cells. The findings from the present study suggested that TSE might possess potent antineoplastic agent having antiproliferative, cytotoxic and apoptogenic activity against U937 and K562 myeloid leukemic cells. 相似文献
3.
4.
Exacerbation of Partial Seizures and Onset of Nonepileptic Myoclonus with Carbamazepine 总被引:4,自引:3,他引:1
A child had two to three generalized tonic-clonic (GTC) seizures per week unresponsive to phenobarbital (PB) and valproate (VPA). Interictal EEG demonstrated left occipital spikes. When carbamazepine (CBZ) therapy was started, he developed very frequent (4-6/day) complex partial seizures (CPS) characterized on ictal EEG by focal right temporal lobe discharges. The seizure exacerbation, which was associated with development of nonepileptic, multifocal myoclonus, resolved 24 h after CBZ was discontinued. The exacerbation occurred with therapeutic CBZ serum levels, but may have been related to the toxic levels of carbamazepine-10, 11-epoxide (CBZE). 相似文献
5.
Sukumaran Anil 《Indian journal of dental research》2006,17(4):151-154
BACKGROUND: Diabetes mellitus is considered as a risk factor for the initiation and progression of periodontal disease. The diabetic patients often exhibit decreased immune response and increased susceptibility to infection. In the present study, a quantitative estimation of the gingival tissue immunoglobulin concentrations in diabetic and non diabetic subjects with periodontitis was assessed and compared with that of clinically healthy gingiva. METHOD: 40 gingival tissue samples obtained from 20 diabetic (Type 2) and 20 non-diabetic subjects were subjected to quantitative estimation of immunoglobulins G, A, and M. The data thus obtained were compared to the level of immunoglobulin found in clinically healthy gingiva. RESULTS: The IgG and IgA level in the tissues of both diabetic and non-diabetic subjects with periodontitis were found to be significantly higher than that of healthy subjects. The diabetic group also showed a significantly higher IgG and IgA levels compared to the non-diabetic group with periodontitis. CONCLUSION: These findings support the concept that the humoral immune response plays an important role in the pathogenesis of periodontal disease in diabetics. The significantly higher levels of immunoglobulin in the gingival tissues might be a protective mechanism against the increased bacterial challenge in diabetic subjects. 相似文献
6.
7.
8.
Anil S Paramesh Ralph B Fairchild Theresa M Quinn Fred Leya Magdalene George David H Van Thiel 《Liver transplantation》2005,11(2):236-238
A 53-year-old male with hepatitis C cirrhosis, who had been refused liver transplantation because of hypertrophic cardiomyopathy (HC), underwent nonsurgical septal ablation using alcohol with resolution of his ventricular outflow obstruction. This patient was able to subsequently undergo a successful deceased donor liver transplantation. This is the first reported case of alcohol induced septal ablation being performed in a cirrhotic patient with HC. Such nonsurgical procedures may be attractive in cirrhotic patients who are refused access to liver transplantation because of high surgical risk. 相似文献
9.
Mahendra Naik Anil Chadha Nayan Parekh Vatsal Patel 《Indian journal of otolaryngology and head and neck surgery》1991,43(1):17-22
Velopharyngeal incompetence (VPI) is a condition of incomplete closure of V.P. port area, normally formed by velum and posterior pharyngeal watt. The condition primarily results in various types of speech defects, which form- the main complaint of the patient. We have studied 10 cases of VPI due to various causes and the speech improvement obtained by flap pharyngoplasty procedures. The results have been evaluated with a follow-up of six months. Highly encouraging results only indicate a more frequent need to undertake such surgery without any hesitation if the ENT surgeon is familiar with and has an adequate exposure to this simple and effective procedure. 相似文献
10.