全文获取类型
收费全文 | 549篇 |
免费 | 39篇 |
专业分类
儿科学 | 14篇 |
妇产科学 | 16篇 |
基础医学 | 77篇 |
口腔科学 | 4篇 |
临床医学 | 62篇 |
内科学 | 113篇 |
皮肤病学 | 6篇 |
神经病学 | 33篇 |
特种医学 | 28篇 |
外科学 | 61篇 |
综合类 | 11篇 |
预防医学 | 70篇 |
眼科学 | 10篇 |
药学 | 32篇 |
肿瘤学 | 51篇 |
出版年
2023年 | 4篇 |
2022年 | 5篇 |
2021年 | 22篇 |
2020年 | 7篇 |
2019年 | 15篇 |
2018年 | 23篇 |
2017年 | 16篇 |
2016年 | 4篇 |
2015年 | 16篇 |
2014年 | 18篇 |
2013年 | 18篇 |
2012年 | 31篇 |
2011年 | 43篇 |
2010年 | 19篇 |
2009年 | 22篇 |
2008年 | 34篇 |
2007年 | 37篇 |
2006年 | 21篇 |
2005年 | 32篇 |
2004年 | 26篇 |
2003年 | 22篇 |
2002年 | 23篇 |
2001年 | 12篇 |
2000年 | 5篇 |
1999年 | 10篇 |
1998年 | 5篇 |
1997年 | 4篇 |
1996年 | 7篇 |
1994年 | 5篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1983年 | 2篇 |
1979年 | 4篇 |
1978年 | 7篇 |
1977年 | 5篇 |
1976年 | 2篇 |
1974年 | 7篇 |
1973年 | 5篇 |
1972年 | 5篇 |
1970年 | 2篇 |
1969年 | 4篇 |
1968年 | 3篇 |
1966年 | 2篇 |
1965年 | 4篇 |
1936年 | 1篇 |
1928年 | 1篇 |
排序方式: 共有588条查询结果,搜索用时 15 毫秒
1.
2.
Arnold Criel Gregor Verhoef Robert Vlietinck Cristina Mecucci Johan Billiet Lucienne Michaux Peter Meeus ries Louwagie Angeline Van Orshoven Achiel Van Hoof Mark Boogaerts Herman Van den Berghe & Chris De Wolf-Peeters 《British journal of haematology》1997,97(2):383-391
We analysed a group of 390 patients, diagnosed with chronic lymphocytic leukaemia (CLL). Cases were subclassified as morphologically typical and atypical CLL according to the criteria of the FAB proposal. Typical CLL cases were mostly diagnosed at a low-risk stage (Binet A/Rai 0), required no immediate treatment and expected a long survival; atypical CLL cases mostly presented at a more advanced risk stage (Binet B/Rai I–II), usually required immediate treatment and their survival was shorter. Moreover, clinical staging was of prognostic significance in typical but not in atypical cases. In typical CLL, del(11q) was the most common chromosomal abnormality (21%) whereas in atypical CLL trisomy 12 was found in about 65% of the cases documented with an abnormal karyotype. Although chromosomal abnormalities were associated with a poor survival in typical CLL, they are of no prognostic significance in atypical CLL. Based on these data, we conclude that subtyping CLL by morphology enables the identification of two groups of cases, each characterized by a specific clinical presentation, different cytogenetic abnormalities and prognostic parameters. We speculate that these two groups may represent two related, but different, diseases with different prognostic parameters and a different survival. 相似文献
3.
Gerhard G. Habermehl Hans C. Krebs Philippe Rasoanaivo Angeline Ramialiharisoa 《Toxicon》1994,32(12):1539-1542
In a single outbreak on the East coast of Madagascar, more than 500 people, 98 of whom died, were poisoned by the flesh of a shark, Carcharhinus amboinensis. From clinical symptoms it can be concluded that this poisoning is due to ciguatera toxins. It is the first case of a severe outbreak caused by a shark, and it is the first case with a mortality rate of 20%. 相似文献
4.
5.
Chee-Kin Hui John Yu Wing Yan Au Hai-ying Zhang Angeline Bartholomeusz Stephen Locarnini Yok-lam Kwong Raymond Liang George K K Lau 《Journal of clinical virology》2005,32(2):173-178
BACKGROUND: After hematopoietic cell transplantation (HCT), hepatitis due to hepatitis B virus (HBV) rarely occurred beyond the initial 12 months after transplantation. OBJECTIVES: We investigated the cause of "late" hepatitis due to HBV infection in two recipients after allogeneic HCT. STUDY DESIGN: Two male patients with acute myeloid leukemia and light chain myeloma, respectively, developed HBV-related hepatitis more than 2 years after HCT. All serum samples collected from the recipients, donors and their respective spouses were tested for HBV DNA by nested PCR, and if positive further quantified by Digene Hybrid Capture assay II. The HBV genotype was determined by PCR and sequencing. RESULTS: Genotypic analysis suggested that the cause of "late" hepatitis was due to acute HBV infection transmitted from their respective spouse. CONCLUSION: Our findings suggested that sexual precautions should be taken in these patients after HCT. Alternatively, or even additionally, active vaccination should be delivered to these patients once they have lost their HBV immunity. 相似文献
6.
HLA Antigens in 16 Families with Xeroderma Pigmentosum 总被引:1,自引:0,他引:1
Gaetano Giraldo Laurent Degos Elke Beth Rhida M. Gharbi Noorbibi K. Day Helene Dastot Margarete Haus Muriel Reboul Michel Schmid 《Tissue antigens》1977,9(3):167-170
Xeroderma pigmentosum is an autosomal recessive disease. HLA-A and -B typing was performed on peripheral blood lymphocytes and platelets. Sixteen Tunisian families were typed with 37 patients and 108 relatives. Genetic transmission of the disease and of the HLA system seemed to be independent in this study. Comparison of HLA gene frequencies between (unrelated) parents of patients and a control population showed no difference, proving that there is no clear association in populations between deleterious XP genes and a particular HLA gene. However, an excess of identical HLA among pairs of diseased siblings would suggest that the disease is polymorphic and a form of the XP could be linked to HLA. 相似文献
7.
Charlotte Cuerq Claire Bordat Charlotte Halimi Emilie Blond Marion Nowicki Noël Peretti Emmanuelle Reboul 《Nutrients》2021,13(1)
(1) Background: vitamin E is often supplemented in the form of tocopherol acetate, but it has poor bioavailability and can fail to correct blood tocopherol concentrations in some patients with severe cholestasis. In this context, α-tocopheryl polyethylene glycol succinate 1000 (TPGS) has been of value, but very little is known about the mechanisms of its absorption. The aim of our work was to evaluate the mechanisms of absorption/secretion of TPGS compared to tocopherol acetate (TAC) and α-tocopherol by human enterocyte-like Caco-2 TC7 cells. (2) Methods: two weeks post-confluence Caco-2 cells were incubated with tocopherol- or TAC- or TPGS-rich mixed micelles up to 24 h and, following lipid extraction, TAC and tocopherol amounts were measured by high performance liquid chromatography (HPLC) in apical, cellular, and basolateral compartments. (3) Results: at equivalent concentrations of tocopherol in the apical side, the amounts of tocopherol secreted at the basolateral pole of Caco-2 cells are (i) significantly greater when the tocopherol is in the free form in the micelles; (ii) intermediate when it is in the TAC form in the micelles (p < 0.001); and (iii) significantly lower with the TPGS form (p < 0.0001). Interestingly, our results show, for the first time, that Caco-2 cells secrete one or more esterified forms of the vitamin contained in TPGS at the basolateral side. 相似文献
8.
Nakai Goredema-Matongera Thokozile Ndhlela Cosmos Magorokosho Casper N. Kamutando Angeline van Biljon Maryke Labuschagne 《Nutrients》2021,13(3)
Macro and micronutrient deficiencies pose serious health challenges globally, with the largest impact in developing regions such as subSaharan Africa (SSA), Latin America and South Asia. Maize is a good source of calories but contains low concentrations of essential nutrients. Major limiting nutrients in maize-based diets are essential amino acids such as lysine and tryptophan, and micronutrients such as vitamin A, zinc (Zn) and iron (Fe). Responding to these challenges, separate maize biofortification programs have been designed worldwide, resulting in several cultivars with high levels of provitamin A, lysine, tryptophan, Zn and Fe being commercialized. This strategy of developing single-nutrient biofortified cultivars does not address the nutrient deficiency challenges in SSA in an integrated manner. Hence, development of maize with multinutritional attributes can be a sustainable and cost-effective strategy for addressing the problem of nutrient deficiencies in SSA. This review provides a synopsis of the health challenges associated with Zn, provitamin A and tryptophan deficiencies and link these to vulnerable societies; a synthesis of past and present intervention measures for addressing nutrient deficiencies in SSA; and a discussion on the possibility of developing maize with multinutritional quality attributes, but also with adaptation to stress conditions in SSA. 相似文献
9.
Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster 总被引:7,自引:0,他引:7
下载免费PDF全文
![点击此处可从《Genome research》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Interferons and interleukin-10 are involved in key aspects of the host defence mechanisms. Human chromosome 21 harbors the interferon/interleukin-10 receptor gene cluster linked to the GART gene. This cluster includes both components of the interferon alpha/beta-receptor (IFNAR1 and IFNAR2) and the second components of the interferon gamma-receptor (IFNGR2) and of the IL-10 receptor (IL10R2). We report here the complete gene content of this GART-cytokine receptor gene cluster and the use of comparative genomic analysis to identify chicken IFNAR1, IFNAR2, and IL10R2. We show that the large-scale structure of this locus is conserved in human and chicken but not in the pufferfish Fugu rubripes. This establishes that the receptor components of these host defense mechanisms were fixed in an ancestor of the amniotes. The extraordinary diversification of the interferon ligand family during the evolution of birds and mammals has therefore occurred in the context of a fixed receptor structure. 相似文献
10.
Conservative treatment for postintubation tracheobronchial rupture 总被引:10,自引:0,他引:10
Jougon J Ballester M Choukroun E Dubrez J Reboul G Velly JF 《The Annals of thoracic surgery》2000,69(1):216-220
BACKGROUND: Postintubation tracheobronchial rupture is usually responsible for unstable intraoperative or postoperative conditions, and its management is discussed. We insist on conservative treatment as a viable alternative after late diagnosis of postintubation tracheobronchial rupture. METHODS: We conducted a retrospective study including 14 consecutive patients treated between April 1981 and July 1998. RESULTS: Twelve tracheobronchial ruptures occurred after intubation for general surgery and two after thoracic surgery. In all cases, the tear consisted of a linear laceration of the posterior membranous wall of the tracheobronchial tree ranging from 2 to 6 cm. One death occurred in a very weak patient unfit to undergo a redo operation for surgical repair. Seven patients were treated conservatively and cured without sequelae. Six patients underwent surgical repair, of whom 2 were diagnosed and repaired intraoperatively. CONCLUSIONS: Aggressive surgical repair is not always mandatory after delayed diagnosis of iatrogenic tracheobronchial rupture. Conservative treatment must often be considered, except after lung resection. 相似文献