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排序方式: 共有743条查询结果,搜索用时 15 毫秒
1.
In this issue of Immunity, Anderson et al. provide another clue to the riddle that is Aire--why do human beings and mice lacking Aire develop diffuse and pathogenic autoimmunity? They find that Aire influences central tolerance not only by promoting the expression of peripheral self-proteins in thymic medullary epithelial cells (MECs) but also by furnishing these cells with the apparatus for effective antigen presentation (). 相似文献
2.
Mallikarjuna Rao GN Hussain T Geetha Devi N Jain S Chandak GR Ananda Raj MP 《Indian journal of medical sciences》2003,57(1):1-6
66 unrelated patients from Southern India with Duchenne Muscular Dystrophy (DMD) were studied for intragenic deletion in 18 exons and Pm region of the DMD gene using multiplex PCR. Of these 41 (62.1%) showed intragenic deletions. 78% of the deletions were located at the distal hotspot region (44-55 exons) and 22% of the deletions were located at the proximal region (exon 2-19). Exon 50 is most frequently deleted. Deletions in isolated cases were significantly more compared to familial cases. The lower incidence reported from South India compared to North India, is suggestive of variations in the Southern and Northern population. 相似文献
3.
Irina Maljkovic Berry Melanie C. Melendrez Simon Pollett Katherine Figueroa Darunee Buddhari Chonticha Klungthong Ananda Nisalak Michael Panciera Butsaya Thaisomboonsuk Tao Li Tyghe G. Vallard Louis Macareo In-Kyu Yoon Stephen J. Thomas Timothy Endy Richard G. Jarman 《Emerging infectious diseases》2021,27(6):1637
Dengue control approaches are best informed by granular spatial epidemiology of these viruses, yet reconstruction of inter- and intra-household transmissions is limited when analyzing case count, serologic, or genomic consensus sequence data. To determine viral spread on a finer spatial scale, we extended phylogenomic discrete trait analyses to reconstructions of house-to-house transmissions within a prospective cluster study in Kamphaeng Phet, Thailand. For additional resolution and transmission confirmation, we mapped dengue intra-host single nucleotide variants on the taxa of these time-scaled phylogenies. This approach confirmed 19 household transmissions and revealed that dengue disperses an average of 70 m per day between households in these communities. We describe an evolutionary biology framework for the resolution of dengue transmissions that cannot be differentiated based on epidemiologic and consensus genome data alone. This framework can be used as a public health tool to inform control approaches and enable precise tracing of dengue transmissions. 相似文献
4.
Beatriz Togoro Ferreira da Silva Livia Tosi Trevelin Ananda Carolina Schroeter Amanda Endres Willers Paulo Francisco Cesar Adriana Bona Matos 《European journal of oral sciences》2021,129(1):e12754
This study investigated the effect of irradiation with an erbium‐doped yttrium aluminium garnet (Er:YAG) laser and coating with silica on the surface characteristics, bond strength, and flexural strength of dental zirconia. Three hundred and forty‐three standard zirconia specimens were created, and 49 were assigned to each of seven surface treatment groups: (i) no treatment; Er:YAG laser (80 mJ/2 Hz) with pulse widths of 50 μs (ii), 100 μs (iii), 300 μs (iv), or 600 μs (v); or tribochemical silica coating at the partially sintered stage (vi) or after sintering was complete (vii). All specimens were sintered after the surface treatments, except for the group in which specimens were sintered before treatment. The study outcomes were roughness, surface loss, microshear bond strength (μSBS), and biaxial flexural strength (BFS). Mean roughness and surface loss values were significantly higher in specimens from irradiated groups than in those from silica‐coated groups. Regarding μSBS, after aging, specimens from all experimental groups presented very low and similar μSBS values, irrespective of the surface treatment. Silica coating after sintering yielded the highest BFS (1149.5 ± 167.6 MPa), while coating partially sintered specimens with silica resulted a BFS (826.9 ± 60.9 MPa) similar to that of the untreated control group (794.9 ± 101.7 MPa). Laser treatments, irrespective of pulse width used, significantly decreased the BFS. In the group treated with laser at 300 μs pulse width, specimens exhibited the lowest BFS value (514.1 ± 71.5 MPa). Adhesion to zirconia was not stable after aging, regardless of the surface treatment implemented. 相似文献
5.
6.
Nina Vyas Kawa Manmi Qianxi Wang Ananda J. Jadhav Mostafa Barigou Rachel L. Sammons Sarah A. Kuehne A. Damien Walmsley 《Ultrasound in medicine & biology》2019,45(5):1044-1055
Bacterial biofilms are a cause of contamination in a wide range of medical and biological areas. Ultrasound is a mechanical energy that can remove these biofilms using cavitation and acoustic streaming, which generate shear forces to disrupt biofilm from a surface. The aim of this narrative review is to investigate the literature on the mechanical removal of biofilm using acoustic cavitation to identify the different operating parameters affecting its removal using this method. The properties of the liquid and the properties of the ultrasound have a large impact on the type of cavitation generated. These include gas content, temperature, surface tension, frequency of ultrasound and acoustic pressure. For many of these parameters, more research is required to understand their mechanisms in the area of ultrasonic biofilm removal, and further research will help to optimise this method for effective removal of biofilms from different surfaces. 相似文献
7.
Laize Peron Tófolo Tatiane Aparecida da Silva Ribeiro Ananda Malta Rosiane Aparecida Miranda Rodrigo Mello Gomes Júlio Cezar de Oliveira Latifa Abdennebi-Najar Douglas Lopes de Almeida Amanda Bianchi Trombini Claudinéia Conationi da Silva Franco Audrei Pavanello Gabriel Sergio Fabricio Wilson Rinaldi Luiz Felipe Barella Paulo Cezar de Freitas Mathias Kesia Palma-Rigo 《European journal of nutrition》2015,54(8):1353-1362
8.
Emily R. Watts Andrew J.M. Howden Tyler Morrison Pranvera Sadiku Jens Hukelmann Alex von Kriegsheim Bart Ghesquiere Fiona Murphy Ananda S. Mirchandani Duncan C. Humphries Robert Grecian Eilise M. Ryan Patricia Coelho Gio Rodriguez Blanco Tracie M. Plant Rebecca S. Dickinson Andy Finch Wesley Vermaelen Doreen A. Cantrell Moira K. Whyte Sarah R. Walmsley 《The Journal of clinical investigation》2021,131(10)
Limiting dysfunctional neutrophilic inflammation while preserving effective immunity requires a better understanding of the processes that dictate neutrophil function in the tissues. Quantitative mass-spectrometry identified how inflammatory murine neutrophils regulated expression of cell surface receptors, signal transduction networks, and metabolic machinery to shape neutrophil phenotypes in response to hypoxia. Through the tracing of labeled amino acids into metabolic enzymes, proinflammatory mediators, and granule proteins, we demonstrated that ongoing protein synthesis shapes the neutrophil proteome. To maintain energy supplies in the tissues, neutrophils consumed extracellular proteins to fuel central carbon metabolism. The physiological stresses of hypoxia and hypoglycemia, characteristic of inflamed tissues, promoted this extracellular protein scavenging with activation of the lysosomal compartment, further driving exploitation of the protein-rich inflammatory milieu. This study provides a comprehensive map of neutrophil proteomes, analysis of which has led to the identification of active catabolic and anabolic pathways that enable neutrophils to sustain synthetic and effector functions in the tissues. 相似文献
9.
Ellen W. Leen-Feldner Matthew T. Feldner Ashley Knapp Liviu Bunaciu Heidemarie Blumenthal Ananda B. Amstadter 《Clinical psychology review》2013
Millions of individuals with posttraumatic stress disorder (PTSD) are parents. A burgeoning literature suggests that offspring of parents with this condition may be at increased risk for psychological problems. The current paper provides an integrative and comprehensive review of the diverse research literature examining the sequelae of parental posttraumatic stress among offspring. Over 100 studies that evaluated psychological and/or biological variables among children of parents with PTSD are reviewed. Findings suggest parental symptoms of posttraumatic stress are uniquely related to an array of offspring outcomes, including internalizing-type problems, general behavioral problems, and altered hypothalamic-pituitary-adrenal axis functioning. Although very little work has directly evaluated mechanisms of transmission, there is increasing support for genetic and epigenetic effects as well as parenting behaviors. These and other mechanisms are discussed; drawing upon findings from other literatures to consider how parental PTSD may impart psychobiological vulnerability upon offspring. We conclude with a detailed discussion of the methodological strengths and challenges of the extant research, along with a recommended agenda for future research in this important area of study. 相似文献
10.
Kyla D. Omilusik J. Adam Best Bingfei Yu Steven Goossens Alexander Weidemann Jessica V. Nguyen Eve Seuntjens Agata Stryjewska Christiane Zweier Rahul Roychoudhuri Luca Gattinoni Lynne M. Bird Yujiro Higashi Hisato Kondoh Danny Huylebroeck Jody Haigh Ananda W. Goldrath 《The Journal of experimental medicine》2015,212(12):2027-2039