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Shymanskaya Aliaksandra Worthoff Wieland A. Stoffels Gabriele Lindemeyer Johannes Neumaier Bernd Lohmann Philipp Galldiks Norbert Langen Karl-Josef Shah N. Jon 《Molecular imaging and biology》2020,22(1):198-207
Molecular Imaging and Biology - Positron emission tomography (PET) using O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) improves the diagnostics of cerebral gliomas compared with conventional... 相似文献
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McKemey Emily Shields Adrian M. Faustini Sian E. Hill Harriet J. Baranskaya Aliaksandra Stamataki Zania Gompertz Simon Richter Alex G. Dosanjh Davinder Madathil Shyam 《Journal of clinical immunology》2021,41(5):930-930
Journal of Clinical Immunology - A Correction to this paper has been published: https://doi.org/10.1007/s10875-021-01029-z 相似文献
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Wieland A. Worthoff Aliaksandra Shymanskaya Johannes Lindemeyer Karl‐Josef Langen N. Jon Shah 《NMR in biomedicine》2020,33(10)
Sodium MRI is a promising method for assessing the metabolic properties of brain tumours. In a recent study, a strong relationship between semi‐quantitative abnormalities in sodium MRI and the mutational status of the isocitrate dehydrogenase enzyme (IDH) with untreated cerebral gliomas was observed. Here, sodium relaxometry in brain tumour tissue was investigated in relation to molecular markers in order to reveal quantitative sodium tissue parameters and the differences between healthy tissue and brain tumour. The previous semi‐quantitative approach is extended by use of suitable relaxometry methods accompanied by numerical simulation to achieve detailed quantitative analysis of intra‐ and extracellular sodium concentration using an enhanced SISTINA sequence at 4 T. Using optimised techniques, biexponential sodium relaxation times in tumour (T*2f, T*2s) and in healthy contralateral brain tissue (T*2f,CL, T*2s,CL) were estimated in 10 patients, along with intracellular sodium molar fractions (χ, χCL), volume fractions (η, ηCL) and concentrations (ρin, ρin,CL). The total sodium tissue concentrations (ρT, ρT,CL) were also estimated. The ratios T*2f/T*2f,CL (P = .05), η/ηCL (P = .02) and χ/χCL (P = .02) were significantly lower in IDH mutated than in IDH wildtype gliomas (n = 4 and n = 5 patients, respectively). The Wilcoxon rank‐sum test was used to compare sodium MRI parameters in patients with and without IDH mutation. Thus, quantitative analysis of relaxation rates, intra‐ and extracellular sodium concentrations, intracellular molar and volume fractions based on enhanced SISTINA confirmed a relationship between abnormalities in sodium parameters and the IDH mutational status in cerebral gliomas, hence catering for the potential to provide further insights into the status of the disease. 相似文献
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Dylan E. Graetz MD MPH Elizabeth Sniderman MSN APRN Cesar A. Villegas MD Erica C. Kaye MD MPH Iman Ragab MD PhD Aliaksandra Laptsevich MD Biemba Maliti BSN Gita Naidu MD PhD Haiying Huang BSN Pascale Y. Gassant MD Luciana Nunes Silva MD Daniela Arce MD Jacqueline Montoya Vasquez MD Ramandeep Singh Arora MD Ana Patricia Alcasabas MD Desy Rusmawatiningtyas MD Muhammad Rafie Raza MD Pablo Velasco MD Joyce Kambugu MD Anna Vinitsky MD MS Carlos Rodriguez-Galindo MD Asya Agulnik MD MPH Daniel C. Moreira MD for the COVIMPACT Study Group 《Cancer》2022,128(4):797-807
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