Biological activity of fluorinated 3,4-dihydroisoquinolines

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 26, No. 1, pp. 44–45, January, 1992.     

Epidemiologic and preventive studies of the precursors of atherosclerosis in children and adults

A total of 1920 schoolchildren of both sexes were examined at 12 to 13 years of age, with a follow-up of 242 children showing elevated BP and a random normotensive sample of 230. A set of features was identified that showed the greatest predictive value with respect to mean BP at five years' follow-up: baseline BP, the Katle index, the magnitude of the S wave and heart rate. A study of possible approaches to the prevention of atherosclerotic precursors in eleven-year-olds has been launched, with the action on certain risk factors, such as limited physical activity, elevated BP, smoking, excessive body weight lipid disorders (in boys only).     

The effect of naloxone on the preoperative gastric volume and pH

The effect of 4 mg oral naloxone on preoperative gastric volume and pH of gastric aspirate was studied in a double-blind, randomized study. Twenty patients received 10 ml of naloxone (4 mg) mixed with 10 ml of orange juice, and 20 patients received 10 ml of isotonic saline mixed with 10 ml of orange juice, 2 h before surgery. Gastric content was obtained immediately after intubation of the trachea. No significant difference in gastric volume and pH of gastric aspirate was found between the two groups. It is concluded that naloxone does not affect gastric emptying and gastric acid secretion to a degree great enough to protect against aspiration of gastric contents into the lungs.