全文获取类型
收费全文 | 320篇 |
免费 | 21篇 |
国内免费 | 24篇 |
专业分类
儿科学 | 28篇 |
妇产科学 | 4篇 |
基础医学 | 29篇 |
口腔科学 | 8篇 |
临床医学 | 33篇 |
内科学 | 77篇 |
皮肤病学 | 5篇 |
神经病学 | 12篇 |
特种医学 | 44篇 |
外科学 | 22篇 |
综合类 | 40篇 |
预防医学 | 18篇 |
眼科学 | 5篇 |
药学 | 21篇 |
肿瘤学 | 19篇 |
出版年
2022年 | 3篇 |
2021年 | 3篇 |
2020年 | 5篇 |
2019年 | 4篇 |
2018年 | 5篇 |
2017年 | 5篇 |
2016年 | 4篇 |
2015年 | 8篇 |
2014年 | 10篇 |
2013年 | 13篇 |
2012年 | 7篇 |
2011年 | 7篇 |
2010年 | 14篇 |
2009年 | 15篇 |
2008年 | 11篇 |
2007年 | 21篇 |
2006年 | 9篇 |
2005年 | 5篇 |
2004年 | 8篇 |
2003年 | 7篇 |
2002年 | 5篇 |
2001年 | 11篇 |
2000年 | 5篇 |
1999年 | 5篇 |
1998年 | 21篇 |
1997年 | 19篇 |
1996年 | 19篇 |
1995年 | 9篇 |
1994年 | 19篇 |
1993年 | 11篇 |
1992年 | 5篇 |
1991年 | 6篇 |
1989年 | 8篇 |
1988年 | 14篇 |
1987年 | 5篇 |
1986年 | 7篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 5篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有365条查询结果,搜索用时 171 毫秒
1.
2.
3.
CG Teo 《Oral diseases》2002,8(S2):88-90
Oral hairy leukoplakia (OHL) and Kaposi's sarcoma (KS) are commonly encountered in the HIV-infected patient. A unique feature of OHL is non-cytolytic high level of replication of Epstein–Barr virus (EBV) in the glossal epithelium. The expression of viral-encoded anti-apoptotic proteins concomitant to replicative proteins probably underlies this phenomenon. The question of whether OHL arises from activation of EBV latent in the tongue, or from superinfection by endogenous EBV shed via non-glossal sites or by exogenous EBV remains unresolved. Human herpesvirus 8 (HHV8) is now seen as necessary but not sufficient cause of KS. Expression of HHV8-encoded oncogenic proteins in endothelial cells probably explains the aberrant proliferation of these cells in KS lesions. Studies into why KS is so commonly observed at the palate in HIV-infected patients may provide important clues to its pathogenesis. 相似文献
4.
5.
Gouandjika I Rakoto Andrianarivelo M Akoua-Koffi C Zeller H Ehouman A Morvan JM 《Bulletin de la Societe de pathologie exotique (1990)》2000,93(3):198-201
Strategies aiming to eradicate the poliovirus and poliomyelitis seek primarily to eliminate wild strains associated with the disease, by means of world wide vaccination campaigns using the oral attenuated vaccine (OPV). OPV contains attenuated viral strains which retain their replicating capacity in the digestive tract and thus induce the development of an antiviral local intestinal immunity and limit the circulation of the virus. In such a context, poliomyelitis surveillance laboratories should study above all cases of acute flaccid paralysis (AFP), highlighting the circulation of wild strains, identifying regional reservoirs and guiding vaccination strategies. Alongside circulation, there appear to be important genetic and phenotypic shifts in vaccinating strains, since the OPV is capable of preserving a reservoir of pathogenic stains and thereby impairing vaccination efficacy and the eradication of the virus. Furthermore, non-polio enteroviruses should be considered as a source of emerging pathogenic strains. These questions are being studied by the Pasteur Institute with the objective of determining the effects of OPV campaigns on the circulation of the poliovirus. We have studied the poliovirus vaccine and the circulation of wild strains in urban and peripheral urban areas in African countries known to be endemic for poliomyelitis (Central African Republic, Madagascar, C?te d'Ivoire). The study population consisted of children who had already been vaccinated and new-borns in the course of vaccination. We also evaluated the diffusion of the vaccine strains in their immediate environment. Genetic interchanges were taken into account. For children who received the 3-4 OPV doses, asymptomatic virus excretion was insignificant (0.4-2.4%). The rate of virus excretion in the surrounding environment of children in the course of being vaccinated was relatively low (1.76-5.3%). Our study also detected variant and recombinant strains. 相似文献
6.
7.
Electropherotypes of Rotaviruses in Children less than 5 years old in Abidjan, Cote D'ivoire in 1997
Rotaviruses Are associated with gastroenteritis in human infants and the young of many species. In this study, we analysed the circulating strains of human rotavirus isolated from young children in Abidjan by electrophoresis of the viral RNA genome in agarose gels. Rotavirus strains were identified in 33 children less than two years of age in the Yopougon district of Abidjan, Cote d'lvoire. Viral RNA was extracted from the stools by phenol-chloroform treatment at 56 degrees C, followed by centrifugation at 12 OOOrpm. The electrophoresis was performed in 1.5 % agarose gels stained with 5 % ethidium bromide and Tris-acetate as the running buffer. Ten ul of each sample was loaded onto the gels which were run at lOOv for 30min. In total, 17 of the 33 specimens yielded an RNA electropherotype. Seven different RNA profiles were observed with 14 (82.4% ) long profiles and 3 (17%) short profiles. These RNA profiles represented the group A rotavirus pattern. No mixed infections were seen. There was no correlation between the age and sex of the patient with the RNA electropherotype. Serogroup A rotaviruses were the principle strains circulating in this study. Further characterization of these strains at the subgroup and serotype level will be conducted. 相似文献
8.
Arif JM; Gairola CG; Glauert HP; Kelloff GJ; Lubet RA; Gupta RC 《Carcinogenesis》1998,19(8):1515-1517
The present study investigated the effects of dietary oltipraz on cigarette
smoke-related lipophilic DNA adduct formation. Female Sprague- Dawley rats
were exposed daily to sidestream cigarette smoke in a whole- body exposure
chamber 6 h/day for 4 consecutive weeks. One group of rats was maintained
on control diet while another group received the same diet supplemented
with either a low (167 p.p.m.) or high (500 p.p.m.) dose of oltipraz,
starting 1 week prior to initiation of smoke exposure until the end of the
experiment. Analysis of lipophilic DNA adducts by the nuclease P1-mediated
32P-post-labeling showed up to five smoke-related adducts. Adduct no. 5
predominated in both the lung and the heart while adduct nos 3 and 2
predominated in the trachea and bladder, respectively. Quantitative
analysis revealed that the total adduct level was the highest in lungs
(270+/-68 adducts/10(10) nucleotides), followed by trachea (196+/-48
adducts/10(10) nucleotides), heart (141+/-22 adducts/10(10) nucleotides)
and bladder (85+/-16 adducts/10(10) nucleotides). High dose oltipraz
treatment reduced the adduct levels in lungs and bladder by >60%, while
the reduction in lungs in the low-dose group was approximately 35%. In
trachea, the effect of low and high dietary oltipraz on smoke DNA adduction
was equivocal, while smoke-related DNA adducts in the heart were minimally
inhibited by high-dose oltipraz. In a repeat experiment that employed a
3-fold lower dose of cigarette smoke, oltipraz (500 p.p.m.) was found to
inhibit the formation of DNA adducts in rat lungs and trachea by 80 and
65%, respectively. These data clearly demonstrate a high efficacy of
oltipraz in inhibiting the formation of cigarette smoke-induced DNA adducts
in the target tissues.
相似文献
9.
Mutation of the p53 tumor suppressor gene in spontaneously occurring osteosarcomas of the dog 总被引:8,自引:0,他引:8
Inactivation of the p53 tumor suppressor gene has been implicated in the
pathogenesis of numerous human cancers, including osteosarcomas.
Appendicular osteosarcomas of the dog appear to be a good model for their
human equivalent with regard to biologic behavior, epidemiology and
histopathology. We individually screened exons 5-8 of the p53 gene for
mutations in 15 canine appendicular osteosarcomas using 'Cold' SSCP to
compare the role of this gene in human and canine osteosarcoma
tumorigenesis. Seven of the tumors (47%) exhibited point mutations, with
one tumor possessing two mutations within different exons. Of these, seven
were missense mutations and the eighth was a 'silent' mutation potentially
affecting the exon 6-7 splicing region. Five of the missense mutations were
located in highly conserved regions IV and V, while another corresponded
with the highly conserved codon 220 mutational hotspot located outside the
conserved domains. The locations and types of mutations were nearly
identical to those reported in human cancer. These findings provide strong
evidence of the involvement of p53 mutations in the development of canine
appendicular osteosarcomas. Canine osteosarcomas appear to be a promising
model for their human equivalent on a clinical, pathologic, and molecular
level.
相似文献
10.
Knowledge,attitude and practice among Health Visitors in the United Kingdom toward children's oral health
下载免费PDF全文
![点击此处可从《Public health nursing (Boston, Mass.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)