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排序方式: 共有576条查询结果,搜索用时 15 毫秒
1.
An immunohistochemical study of bone morphogenetic protein in pleomorphic adenoma of the salivary gland 总被引:4,自引:0,他引:4
Yang Lianjia Jin Yan Nakamine Hitoshi Sumitomo Shinichiro Kamegai Akihide Mori Masahiko 《Virchows Archiv : an international journal of pathology》1993,422(6):439-443
Bone morphogenetic protein (BMP) is a potent induction factor for new bone formation including heterotopic chondro-ossification in soft tissues. The immunohistochemical reaction for BMP was studied in 23 cases of pleomorphic adenoma of salivary gland by using a monoclonal antibody produced by hybridoma technique. Positive BMP immunoreactivity was seen in 87% of tumours. Immunohistochemical expression of BMP was observed in modified myoepithelial cells (88% cases), luminal tumour cells of tubulo-ductal structures (78% cases) and chondroid cells in hyaline tissue (22% cases). The authors concluded that the simultaneous presence of glycosaminoglycans as matrix substance and S-100 protein for calcium signalling are associated with BMP-mediated cellular activity of modified myoepithelial cells in the formation of chondroid structures in pleomorphic adenomas of the salivary glands. 相似文献
2.
Eric Wang Sydney X. Lu Alessandro Pastore Xufeng Chen Jochen Imig Stanley Chun-Wei Lee Kathryn Hockemeyer Yohana E. Ghebrechristos Akihide Yoshimi Daichi Inoue Michelle Ki Hana Cho Lillian Bitner Andreas Kloetgen Kuan-Ting Lin Taisuke Uehara Takashi Owa Raoul Tibes Iannis Aifantis 《Cancer cell》2019,35(3):369-384.e7
3.
Morimatsu Y Matsubara S Hirose N Ohkuchi A Izumi A Ozaki K Ozawa K Suzuki M 《Archives of gynecology and obstetrics》2008,277(3):267-270
Background Disseminated intravascular coagulation (DIC) caused by placental abruption usually improves rapidly after prompt delivery
and adequate anti-DIC treatment.
Case A 30-year-old nulliparous woman suffered from placental abruption at the 25th week of pregnancy, and emergent cesarean section
was done immediately. She exhibited DIC, which continued even after termination of the pregnancy and anti-DIC treatment. She
also showed neutropenia. We closely observed her, and at the 58th day postpartum, blast cells appeared in the peripheral blood
and she was diagnosed with acute promyelocytic leukemia (APL). Induction chemotherapy was done successfully. The close observation
after delivery enabled us to make the prompt diagnosis/treatment, leading to the complete remission.
Conclusion APL should be added to the list of differential diagnosis when DIC persists even after prompt delivery and appropriate anti-DIC
treatment after placental abruption. 相似文献
4.
Tsubasa Hiraki Miho Hatanaka Akiko Arimura Hisao Kawahira Mari Kirishima Ikumi Kitazono Michiko Horinouchi Michiyo Higashi Takuro Kanekura Akihide Tanimoto 《Journal of cutaneous pathology》2020,47(2):154-160
Nivolumab and pembrolizumab are humanized IgG4 monoclonal antibodies against programmed cell death 1 (PD-1). Although these agents are effective in treating advanced melanoma, non-small-cell lung carcinoma, and other types of cancers, various adverse events have been reported. Cutaneous adverse events are particularly prevalent and, while granulomatous/sarcoid-like reactions are uncommon, they are increasingly recognized as immune-related adverse events associated with immune checkpoint inhibitors. Herein, we report two cases of granulomatous/sarcoid-like reaction with foreign material, mimicking metastatic malignancy after PD-1 inhibitor treatment. Clinicians should be aware of the existence of cutaneous lesions and perform biopsy if needed to prevent misdiagnosis and unnecessary adjustments to immunotherapy. 相似文献
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6.
Goshi Shiota Ken‐ichi Harada Kenji Oyama Akihide Udagawa Takahiro Nomi Kiwamu Tanaka Atsushi Tsutsumi Naoya Noguchi Yosuke Kishimoto Yutaka Horie Takeaki Suou Hironaka Kawasaki 《Liver international》2000,20(5):415-420
Abstract: We present a case of severe exacerbation of hepatitis after short‐term corticosteroid therapy for chronic inflammatory demyelinating polyneuropathy (CIPD) with “latent” chronic hepatitis B showing no HBV‐related antigens and antibodies. After corticosteroid pulse therapy for CIPD, the patient had severe exacerbation of hepatitis twice. Although she did not show any hepatitis B virus (HBV)‐related antigens or antibodies, sequences of HBV were detected in serum and liver by a nested polymerase chain reaction. A sequence analysis of HBV at the second exacerbation showed that the G‐to‐A point mutation at nucleotide 1896 that converted codon 28 from tryptophan (TGG) to a stop codon (TAG) in the precore region resulted in amino acid change, which has been frequently observed in fulminant hepatitis and severe hepatitis in Japan. 相似文献
7.
Chieko Sakano Makoto Kuroda Tsuyoshi Sekizuka Taisei Ishioka Yukio Morita Akihide Ryo Hiroyuki Tsukagoshi Yuko Kawai Nobuko Inoue Hayato Takada Yumiko Ogaswara Atsuyoshi Nishina Masa-aki Shimoda Kunihisa Kozawa Kazunori Oishi Hirokazu Kimura 《Journal of clinical microbiology》2013,51(1):328-330
Whole-genome sequencing of non-H2S-producing Salmonella enterica serovar Typhimurium and S. enterica serovar Infantis isolates from poultry meat revealed a nonsense mutation in the phsA thiosulfate reductase gene and carriage of a CMY-2 β-lactamase. The lack of production of H2S might lead to the incorrect identification of S. enterica isolates carrying antimicrobial resistance genes. 相似文献
8.
9.
Cultured rat hepatocytes were used to study the effects of hormones on the production of apo A-I. In addition, we compared these effects with the production of albumin. Hepatocytes were isolated from normal adult rat livers and cultured in MEM, as nearly confluent monolayers. In the absence of hormones, apo A-I and albumin accumulated in the culture medium almost linearly for periods up to 24 h. The rates of accumulation of apo A-1 and albumin in the medium were 22 ng/mg cell protein per h and 1.2 μg/mg cell protein per h, respectively. During the incubations the cellular contents of apo A-1 remained constant.
Insulin stimulated the production of albumin at concentrations over 10−10 M, but inhibited the production of apo A-I at concentrations over 10−8 M. Dexamethasone showed no significant effects on albumin production but stimulated apo A-1 production at concentrations over 10−6 M. Glucagon inhibited the production of albumin and apo A-I dose-dependently at concentrations over 10−10 M. Thus, the production of albumin and apo A-1 are presumably controlled by different regulatory mechanisms. 相似文献
10.