全文获取类型
收费全文 | 1205篇 |
免费 | 59篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 39篇 |
妇产科学 | 18篇 |
基础医学 | 200篇 |
口腔科学 | 31篇 |
临床医学 | 123篇 |
内科学 | 262篇 |
皮肤病学 | 51篇 |
神经病学 | 97篇 |
特种医学 | 43篇 |
外科学 | 145篇 |
综合类 | 11篇 |
预防医学 | 61篇 |
眼科学 | 2篇 |
药学 | 89篇 |
中国医学 | 5篇 |
肿瘤学 | 86篇 |
出版年
2023年 | 5篇 |
2022年 | 13篇 |
2021年 | 41篇 |
2020年 | 16篇 |
2019年 | 23篇 |
2018年 | 34篇 |
2017年 | 18篇 |
2016年 | 18篇 |
2015年 | 26篇 |
2014年 | 27篇 |
2013年 | 39篇 |
2012年 | 94篇 |
2011年 | 76篇 |
2010年 | 33篇 |
2009年 | 35篇 |
2008年 | 59篇 |
2007年 | 51篇 |
2006年 | 49篇 |
2005年 | 38篇 |
2004年 | 50篇 |
2003年 | 38篇 |
2002年 | 41篇 |
2001年 | 21篇 |
2000年 | 18篇 |
1999年 | 22篇 |
1998年 | 8篇 |
1997年 | 7篇 |
1996年 | 10篇 |
1995年 | 11篇 |
1994年 | 15篇 |
1993年 | 16篇 |
1992年 | 42篇 |
1991年 | 24篇 |
1990年 | 25篇 |
1989年 | 42篇 |
1988年 | 20篇 |
1987年 | 27篇 |
1986年 | 25篇 |
1985年 | 24篇 |
1984年 | 13篇 |
1983年 | 10篇 |
1982年 | 5篇 |
1981年 | 7篇 |
1980年 | 5篇 |
1979年 | 8篇 |
1978年 | 7篇 |
1977年 | 7篇 |
1974年 | 8篇 |
1973年 | 4篇 |
1972年 | 4篇 |
排序方式: 共有1273条查询结果,搜索用时 15 毫秒
1.
C M Pesce 《Public health reports (Washington, D.C. : 1974)》1986,101(4):417-419
Histopathology may serve a wide spectrum of diagnostic purposes in tropical medicine other than for infectious and parasitic diseases. In addition, it is essential in defining new pathological entities and collecting statistical data on morbidity and mortality. It should also constitute a basic support for advancement and research in tropical diseases. For practical purposes, both histopathology and cytopathology are often more effective than clinical chemistry and microbiology in providing the clinician with a final diagnosis. They do not rely on complicated and delicate equipment, and the few reagents they require can be stored indefinitely. Formalin fixation permits most histological methods to be used, including special stains and immunohistochemistry. Formalin-fixed material can be examined several days after excision. Implementing pathology laboratories in tropical countries may constitute a practical, cost-effective approach to the planning of diagnostic services at the regional or district level. A fraction of the medical graduates in developing countries should be devoted to the staffing of these laboratories. 相似文献
2.
Leandro Provinciali Mario Signorino Bruno Censori Gabriella Ceravolo Maria Del Pesce 《Epilepsia》1991,32(5):684-689
The occurrence of transitory cognitive impairment during diffuse subclinical electroencephalographic (EEG) discharges has been widely documented but the role of the parameters influencing the cognitive performance and the involvement of motor or verbal response in the tasks used is still under debate. Fifteen patients suffering from primary generalized epilepsy with frequent bisynchronous EEG epileptic bursts underwent a shape recognition task during EEG monitoring. The test sequence was as follows: memorandum, pause, and multiple choice set. After pressing the response button, the patient was asked to confirm the choice verbally. The following parameters were considered: geometrical complexity of the shape, chronological position of the burst occurring during the single test, and the duration of discharge ranging from 1 to 3 s. Results showed a significant increase in incorrect responses during the test when discharges occurred, with more errors occurring for difficult than for easy shapes. Neither the discharge position nor the duration of the epileptic burst influenced the performance. Diffuse epileptic activity of short duration produced selective effects on the cognitive process regardless of the motor component of the response. 相似文献
3.
IgA antiendomysium antibodies in human umbilical cord sections as a screening test in relatives of patients with celiac disease 总被引:1,自引:0,他引:1
M. Bagnasco P. Montagna A. De Alessandri E. Castellano G. P. Pesce R. Gatti 《Allergy》1997,52(10):1017-1021
We performed the serum IgA antiendomysium antibody (EmA) assay by indirect immunofluorescence on human umbilical cord sections in 86 subjects with celiac disease, in 187 first-degree relatives of such patients, and in a control group of 68 unrelated subjects, to investigate the suitability of the method in the screening of populations at risk of gluten sensitivity. Conventional EmA assay using monkey esophagus sections was performed in parallel experiments. The results obtained showed a perfpect correlation between the two methods. All the celiac patients and none of the controls were positive for EmA. EmA positivity was also observed in 11 apparently healthy relatives: intestinal biopsy performed in five of them invariably showed villous atrophy and increase of mucosal lymphocytes. Taking into account the low cost of EmA assay on human umbilical cord, especially when compared to monkey esophagus sections, the method is probably suitable and effective in identifying latent, asymptomatic gluten sensitivity in at-risk populations. 相似文献
4.
Maria Cristina Locatelli Lucilla Tedeschi Maurizia Clerici Antonella Romanelli Adelaide D'Antona Roberto Labianca Gino Luporini 《Supportive care in cancer》1996,4(3):218-219
We have reviewed the incidence of cisplatin-induced anaemia in patients affected with solid tumours treated with at least three courses of first-line cisplatincontaining regimens. In our experience, a low percentage (5%) of patients required transfusions of red blood cells. We think it is of the utmost importance to adopt uniform criteria in monitoring and treatment of patients at risk of developing cisplatin anaemia and to identify subsets of patients to eventually treat with erythropoietin. 相似文献
5.
6.
Do weekly and fast-rotating shiftwork schedules differentially affect duration and quality of sleep?
F. M. Fischer Antonio Castro Bruni Adelaide Berwerth Claudia Roberta Castro Moreno Rosaneli Lima Fernandez Claudia Riviello 《International archives of occupational and environmental health》1997,69(5):354-360
Characteristics of shiftwork schedules can have distinct impacts on workers’ sleep. This report presents comparisons of the
effects of two different shiftwork schedules on duration and quality of the main sleep episodes in comparable worker populations
at two different petrochemical plants. No significant differences were found for sleep duration in comparing the two plants.
However, within each plant’s shift cycles, morning and night shifts showed shorter sleep durations than all other workdays
and days off. Quality of sleep was perceived as lowest for night shifts of both plant schedules, and of lesser quality for
weekly than for fast-rotating shifts. These results support recommendations for reducing the number of consecutive nights
of shiftwork. However, before recommending any optimal shift schedule, interactions of sleep duration and quality with shift
schedules need much further evaluation.
Received: 18 December 1995/Accepted: 18 July 1996 相似文献
7.
8.
Tancredi M Sensi E Cipollini G Aretini P Lombardi G Di Cristofano C Presciuttini S Bevilacqua G Caligo MA 《European journal of human genetics : EJHG》2004,12(9):775-777
Germ-line mutations in the BRCA1 gene cause hereditary predisposition to breast and ovarian cancer. BRCA1 and BRCA2 mutations account for about 40% of high-risk families. Mutation-screening methods generally focus on genomic DNA and are usually PCR based; they enable the detection of sequence alterations such as point mutations and small deletions and insertions. However, they do not allow the detection of partial or entire exon(s) loss, because the presence of the homologous allele results in a positive PCR signal, giving rise to a false-negative result. Identification of unusual haplotypes in patient samples by an expectation maximization algorithm has recently been suggested as a method for identifying hemizygous regions caused by large intragenic deletions. Using a similar approach, we identified a novel BRCA1 genomic rearrangement in a breast/ovarian cancer family negative at the first mutation screening; we detected a deletion encompassing exons 14-19, probably due to replication slippage between Alu sequences. 相似文献
9.
Requirements for the development of IL-4-producing T cells during intestinal nematode infections: what it takes to make a Th2 cell in vivo 总被引:1,自引:0,他引:1
Zhugong Liu Qian Liu John Pesce Robert M. Anthony Erika Lamb Jeannette Whitmire Hossein Hamed Motoko Morimoto Joseph F. Urban Jr William C. Gause 《Immunological reviews》2004,201(1):57-74
Summary: Components of the type 2 immune response may mediate host protection against both helminthic parasites and harmful allergic responses. A central player in this response is the T‐helper 2 (Th2) effector cell, which produces interleukin (IL)‐4, IL‐5, IL‐13, and other Th2 cytokines during the primary and memory response. Specific aspects of the parasite that trigger Th2‐cell differentiation are not yet defined. Furthermore, the cell types and cell surface and secreted molecules that provide the immune milieu required for the development of Th2 effector cells and also Th2 memory cells are not well understood. They will probably vary with the particular helminth or other antigen inducing the Th2 response. We have used third stage larvae of intestinal nematode parasites as adjuvants to promote naïve nonparasite antigen‐specific T cells to differentiate into Th2 cells. This model system avoids possible parasite antigen‐specific T‐cell clones or cross‐reactive memory T cells that may preferentially differentiate into Th2 effector cells during the course of infection and confound the stereotypical components of parasite‐induced Th2 cell differentiation. We have found that these parasites have a potent adjuvant effect and have used our model system to begin to investigate the events that lead to the development of polarized Th2 cells in vivo. 相似文献
10.
Single nucleotide polymorphic alleles in the 5' region of the RET proto-oncogene define a risk haplotype in Hirschsprung's disease 总被引:4,自引:0,他引:4
下载免费PDF全文
![点击此处可从《Journal of medical genetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)