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1.
Etheldreda Nakimuli-Mpungu James Okello Eugene Kinyanda Stephen Alderman Juliet Nakku Jeffrey S. Alderman Alison Pavia Alex Adaku Kathleen Allden Seggane Musisi 《Journal of affective disorders》2013
Background
The effectiveness of group interventions for adults with mental distress in post-conflict settings is less clear in sub-Saharan Africa.Aim
To assess the impact of group counseling intervention on depression, post-traumatic stress and function outcomes among adults attending the Peter C. Alderman Foundation (PCAF) trauma clinics in northern Uganda.Methods
631 War affected adults were enrolled into PCAF trauma clinics. Using a quasi-experimental design, assessments were conducted at baseline, at 3 and 6 months following initiation of care. Multivariate longitudinal regression models were used to determine change in depression, post-traumatic stress and function scores over time among group counseling participants and non-participants.Results
In comparison to non-participants, participants had faster reduction in depression scores during the 6-month follow-up period [β=−1.84, 95%CI (−3.38 to −0.30), p=0.019] and faster reduction in post-traumatic stress scores during the 3-month follow-up period [β=−2.14, 95%CI (−4.21 to −0.10), p=0.042]. At 3-month follow up, participants who attended two or more sessions had faster increase in function scores [β=3.51, 95%CI (0.61–6.40), p=0.018] than participants who attended only one session.Limitations
Selection bias due to the use of non-random samples. Substantial attrition rates and small sample sizes may have resulted in insufficient statistical power to determine meaningful differences.Conclusion
The group counseling intervention offered in the PCAF clinics may have considerable mental health benefits over time. There is need for more research to structure, standardize and test the efficacy of this intervention using a randomized controlled trial. 相似文献2.
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Irabor EE Falodun A Obasuyi O Ofoegbu CO Abiodun SO Umujeyan K 《Acta poloniae pharmaceutica》2007,64(5):449-451
The crude extract of Colliandra surinamensis is used in traditional medicine for the treatment of some diseases/infections. The crude extract obtained from the flower of Colliandra surinamensis was found to have antimicrobial activity against some Gram positive organisms such as Staphylococcus aureus, Bacillus subtilis and Steptococcus species. The performance of the extract against the bacteria isolates was favorably comparable with established commercial antibacterial agents. 相似文献
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Ijeoma Adaku Umelo Olivier De Wever Peter Kronenberger Jan Van Deun Alfiah Noor Kshitiz Singh Erik Teugels Gang Chen Marc Bracke Jacques De Grève 《Oncotarget》2015,6(24):20132-20144
KRAS is a frequently mutated oncogene in lung cancer and among the most refractory to EGFR targeted therapy. Recently, preclinical evidence in pancreatic cancer has demonstrated that mutant KRAS can be regulated by EGFR. However, the distinct correlation between the EGFR/HER family members and mutant KRAS has not been investigated. Here, we show that non-small cell lung cancer cell lines harboring differing isoforms of mutant KRAS, can be broadly divided into EGFR/HER dependent and EGFR/HER independent groups. Combined therapeutic targeting of EGFR, HER2 and HER3 in isoforms regulated by extracellular growth signals promotes in vitro and in vivo efficacy. We also provide evidence that depletion of EGFR via RNA interference specifically abolishes the EGFR/KRAS interaction in the dependent subset. Taken together, these findings suggest that upstream inhibition of the EGFR/HER receptors may be effective in treating a subset of KRAS mutant lung cancers. 相似文献
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Motorcycle injuries in a developing country and the vulnerability of riders, passengers, and pedestrians. 下载免费PDF全文
B A Solagberu C K P Ofoegbu A A Nasir O K Ogundipe A O Adekanye L O Abdur-Rahman 《Injury prevention》2006,12(4):266-268
At a Nigerian university hospital, none of the motorcyclists who presented over a 12 month period had been wearing a helmet, and of the eight patients who died, seven had head injuries. Of the five collision types described, the rate of motorcycle-other vehicle collisions was highest at 40.6%, while the motorcycle-pedestrian rate was 23.4%. Measures to prevent these collisions might reduce overall crashes by 64%; in addition, helmet law should be enforced. 相似文献
10.
Rotimi CN Chen G Adeyemo AA Furbert-Harris P Parish-Gause D Zhou J Berg K Adegoke O Amoah A Owusu S Acheampong J Agyenim-Boateng K Eghan BA Oli J Okafor G Ofoegbu E Osotimehin B Abbiyesuku F Johnson T Rufus T Fasanmade O Kittles R Daniel H Chen Y Dunston G Collins FS Guass D;Africa America Diabetes Mellitus 《Diabetes》2004,53(3):838-841
The incidence of type 2 diabetes is growing rapidly, not only in developed countries but also worldwide. We chose to study type 2 diabetes in West Africa, where diabetes is less common than in the U.S., reasoning that in an environment where calories are less abundant, incident cases of type 2 diabetes might carry a proportionately greater genetic component. Through the Africa America Diabetes Mellitus (AADM) study, we carried out a genome-wide linkage analysis of type 2 diabetes in a cohort of 343 affected sibling pairs (691 individuals) enrolled from five West African centers in two countries (Ghana: Accra and Kumasi; Nigeria: Enugu, Ibadan, and Lagos). A total of 390 polymorphic markers were genotyped, and multipoint linkage analysis was conducted using the GENEHUNTER-PLUS and ASM programs. Suggestive evidence of linkage was observed in four regions on three chromosomes (12, 19, and 20). The two largest logarithm of odds scores of 2.63 and 1.92 for chromosomes 20q13.3 and 12q24, respectively, are particularly interesting because these regions have been reported to harbor diabetes susceptibility genes in several other populations and ethnic groups. Given the history of forced migration of West African populations during the slave trade, these results should have considerable relevance to the study of type 2 diabetes in African Americans. 相似文献