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1.
WHITE FIBROUS PAPULOSIS OF THE NECK 总被引:2,自引:0,他引:2
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SEVERO SALVADORI REMO GUERRINI PIERO ANDREA BOREA ROBERTO TOMATIS 《Chemical biology & drug design》1992,40(5):437-444
The synthesis of pseudotetrapeptides H-Tyr-D-Ala-Phe-NH-(CH2)2-NH2 (1a), H-Tyr-D-Ala-Phe-ψ(CH2-NH)-Gly-NH2 (2a), H-Tyr-D-Ala-ψ(CH2-NH)-Phe-Gly-NH2 (3a), and H-Tyr-ψ(CH2-NH)-D-Ala-Phe-Gly-NH2 (4a), representing the N-terminal tetrapeptide sequence of dermorphin, in which amide bonds are replaced by CH2-NH bond, is described. N-acetyl-Tyr and desamino-Tyr pseudopeptide analogs (1-4b), (1-3c) are also described. The analogs were assayed in binding studies based on displacement of μ and δ-receptor selective radiolabels from rat brain membrane and in a bioassay using guinea pig ileum (GPI). Pseudopeptides in which the C-terminal (1a) or D-Ala-Phe (3a) amide bond are substituted, exhibit higher μ-affinities and μ-receptor selectivity than the corresponding Phe-Gly or Tyr-D-Ala analogs (2a, 4a). Acetyl-and desamino-Tyr pseudopeptide analogs (1-4b) and (1-3c) did not exhibit μ and δ-opioid receptor affinity at nM concentration. The relevance of the single peptide replacement and of its association to acetylation or amino group elimination of Tyr, is discussed on the basis of a receptor model for μ and δ opioids. 相似文献
3.
MANT ANDREA; EYLAND E ANN; POND DIMITY C; SAUNDERS NICHOLAS A; CHANCELLOR ALAN H B 《Family practice》1988,5(3):184-188
Mant A, Eyland E A, Pond D C, Saunders N A and Chancellor AH B. Recognition of dementia in general practice: comparisonof general practitioners' opinions with assessments using themini-mental state examination and the Blessed dementia ratingscale. Family Practice 1988; 5: 184188. In a study of 226 elderly residents in a retirement villagein Sydney, Australia, general practitioners' opinions aboutdementia status had high positive and negative predictive valuesand high specificity, but low sensitivity when evaluated againstthe mini-mental state examination and the Blessed dementia ratingscale. General practitioners were found to disagree with thesetwo measures more often when patients were in advanced old age,and when they considered the patients to be depressed. We concludethat the general practitioner can increase his or her sensitivityto dementia in the elderly by use of either measure. 相似文献
4.
ANDREA SGOIFO SIETSE F DE BOER JOZSEF HALLER JAAP M KOOLHAAS 《Physiology & behavior》1996,60(6):1403-1407
Plasma noradrenaline (NA), adrenaline (A), and corticosterone (CS) responses to social and nonsocial stressors were studied in male members of a strain of wild-type rats, widely differing in their level of aggression. The aggressiveness was preliminarily established by measuring the latency time to attack (ALT) a male intruder in a standard resident-intruder test. Animals were then provided with a jugular vein cannula for blood sampling during stress exposure. Implanted rats were randomly assigned to 3 experimental treatments: social stress (defeat experience, SD), nonsocial stress (presentation of a shock-prod, SP) and control (animals undisturbed in their home cages, CTR). A significant correlation was found between ALT and the amount of time spent in burying the probe in SP rats: the more aggressive the animal, the higher the rate of burying behavior. SD induced a much stronger effect on plasma NA, A, and CS concentrations than SP. A significant negative correlation was found between ALT scores and values of the area under the response time curve for NA and A, in both SD and SP situations: the more aggressive the animal, the higher the catecholaminergic reactivity to the stressors. On the contrary, no evidence of a correlation between aggressiveness and plasma corticosterone responses was found, neither in SD nor in SP rats. These findings in an unselected strain of wild-type rats confirmed that an aggressive/active coping strategy is associated with a high sympathetic-adrenomedullary activation and support the concept of individual differentiation in coping styles as a coherent set of behavioral and neuroendocrine characteristics. 相似文献
5.
ANDREA SGOIFO DONATELLA STILLI DANTE MEDICI PAOLA GALLO BEATRICE AIMI EZIO MUSSO 《Physiology & behavior》1996,60(6):1397-1401
We describe a surgical procedure for optimizing the location of telemetry ECG leads in rats. The new location was aimed at obtaining an accurate representation of ECG features throughout the cardiac cycle by limiting the voltage instability usually observed during intense somatomotor activity and improving the signal-to-noise ratio. The two electrodes (wire loops) were fixed on the dorsal surface of the xiphoid process and in the anterior mediastinum close to the right atrium. The implantation procedure was fast, little invasive, and allowed animals to completely recover from intervention. The performance of the “improved” location (IL, n = 10) with respect to two subcutaneous (SC) positionings (“conventional positioning,” CSP, n = 5; “updated location,” USL, n = 5) was evaluated by comparing ECGs obtained in baseline, stress and recovery conditions and during different behavioral activities (immobility and grooming). The resident-intruder test (emotional/physical challenge) was chosen as experimental stress paradigm. The noise level of ECGs obtained from IL rats was lower than in CSP and USL animals, in all recording conditions. Percentages of correctly recognized beats (CRBs) over the total number of beats (TBs) were significantly higher in IL rats than in CSP and USL animals, both in baseline conditions (99% vs. 11% and 40%) and situations involving high somatomotor activity (stress: 97%, 5% and 16%; recovery: 97%, 7%, and 15%) (p < 0.01). The performance of IL as compared to CSP and USL was also better when percentages during grooming and immobility were considered (grooming: 93% vs. 4% and 23%; immobility: 97%, 6%, and 33%; p < 0.01). 相似文献
6.
POTOKAR JOHN; COUPLAND NICK; GLUE PAUL; GROVES SIMON; MALIZIA ANDREA; BAILEY JAYNE; WILSON SUE; NUTT DAVID 《Alcohol and alcoholism (Oxford, Oxfordshire)》1997,32(5):605-611
The purpose of the present study was to study -aminobutyricacid (GABA)-A receptor function in alcohol-dependent subjectsduring withdrawal, using the benzodiazepine antagonist flumazenil.In particular, we wanted to examine the hypotheses that an endogenousinverse agonist ligand at the GABA-A benzodiazepine receptor(GBzR) is active during withdrawal (in which case flumazenilshould be anxiolytic), or whether chronic alcohol intake resultsin a shift in sensitivity of the receptor in the inverse agonistdirection (in which case flumazenil should be anxiogenic). Resultsfrom 15 alcohol-dependent subjects in a double-blind placebo-controlledcross-over study showed that flumazenil was neither anxiolyticnor anxiogenic, although withdrawal scores were reduced duringthe course of the study. The fact that flumazenil was not anxiogenic,as it is in panic disorder, suggests that the GBzR is functioningdifferently in these two clinically similar conditions. 相似文献
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8.
DHANUNJAYA LAKKIREDDY M.D. ARUN KANMANTHAREDDY M.D. MAZDA BIRIA M.D. YERUVA MADHU REDDY M.D. JAYASREE PILLARISETTI M.D. SRIJOY MAHAPATRA M.D. LOREN BERENBOM M.D. LARRY CHINITZ M.D. DONITA ATKINS R.N. SUDHARANI BOMMANA M.Phil. RODERICK TUNG M.D. LUIGI DI BIASE M.D. KALYANAM SHIVKUMAR M.D. ANDREA NATALE M.D. 《Journal of cardiovascular electrophysiology》2014,25(7):739-746
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10.
SANGHAMITRA MOHANTY M.D. M.S. F.H.R.S. PRASANT MOHANTY M.B.B.S. M.P.H. LUIGI DI BIASE M.D. Ph.D. F.H.R.S. RONG BAI M.D. F.H.R.S. CHINTAN TRIVEDI M.D. M.P.H. PASQUALE SANTANGELI M.D. FRANCESCO SANTORO M.D. RICHARD HONGO M.D. STEVEN HAO M.D. SALWA BEHEIRY R.N. DAVID BURKHARDT M.D. JOSEPH G. GALLINGHOUSE M.D. RODNEY HORTON M.D. JAVIER E. SANCHEZ M.D. SHANE BAILEY M.D. PATRICK M. HRANITZKY M.D. JASON ZAGRODZKY M.D. ANDREA NATALE M.D. F.H.R.S. F.E.S.C. F.A.C.C. 《Journal of cardiovascular electrophysiology》2014,25(9):930-938