全文获取类型
收费全文 | 8244篇 |
免费 | 223篇 |
国内免费 | 53篇 |
专业分类
耳鼻咽喉 | 100篇 |
儿科学 | 1125篇 |
妇产科学 | 92篇 |
基础医学 | 809篇 |
口腔科学 | 287篇 |
临床医学 | 672篇 |
内科学 | 1610篇 |
皮肤病学 | 168篇 |
神经病学 | 446篇 |
特种医学 | 235篇 |
外科学 | 1022篇 |
综合类 | 129篇 |
一般理论 | 2篇 |
预防医学 | 770篇 |
眼科学 | 97篇 |
药学 | 444篇 |
中国医学 | 40篇 |
肿瘤学 | 472篇 |
出版年
2023年 | 35篇 |
2022年 | 74篇 |
2021年 | 200篇 |
2020年 | 122篇 |
2019年 | 260篇 |
2018年 | 402篇 |
2017年 | 279篇 |
2016年 | 286篇 |
2015年 | 191篇 |
2014年 | 273篇 |
2013年 | 312篇 |
2012年 | 550篇 |
2011年 | 2211篇 |
2010年 | 915篇 |
2009年 | 483篇 |
2008年 | 299篇 |
2007年 | 249篇 |
2006年 | 164篇 |
2005年 | 153篇 |
2004年 | 99篇 |
2003年 | 77篇 |
2002年 | 72篇 |
2001年 | 59篇 |
2000年 | 42篇 |
1999年 | 52篇 |
1998年 | 54篇 |
1997年 | 34篇 |
1996年 | 54篇 |
1995年 | 51篇 |
1994年 | 51篇 |
1993年 | 32篇 |
1992年 | 39篇 |
1991年 | 27篇 |
1990年 | 18篇 |
1989年 | 17篇 |
1988年 | 11篇 |
1985年 | 15篇 |
1983年 | 11篇 |
1980年 | 9篇 |
1978年 | 11篇 |
1977年 | 11篇 |
1975年 | 18篇 |
1974年 | 9篇 |
1973年 | 14篇 |
1970年 | 8篇 |
1969年 | 11篇 |
1967年 | 10篇 |
1964年 | 13篇 |
1961年 | 12篇 |
1959年 | 7篇 |
排序方式: 共有8520条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
Flavia M. N. P. Aslanian Maria Teresa Q. Marques Haroldo J. Matos Luciane F. S. Pontes Luis Cristvo S. Porto Lucia M. S. Azevedo Absalom L. Filgueira 《Journal der Deutschen Dermatologischen Gesellschaft》2006,4(10):842-847
Background: Lichen sclerosus (LS) has been identified with increased frequency in families,often associated with HLA markers, mainly DQ7. A genetic co‐etiology seems likely in this setting. Moreover, there is an association of LS with autoimmune disorders, such as the presence of anti‐thyroid peroxidase autoantibodies (anti‐TPO), a hallmark of autoimmune thyroid diseases. Patients and Methods: In 3 families affected by LS, we verified their HLA markers, and identified previously undiagnosed cases of LS and autoimmune disorders. 30 individuals were examined with history, skin biopsy, HLA class I and II typing by PCR‐SSP, and measurement of anti‐TPO, free thyroxine and thyroidstimulating hormones (TSH) levels. Results: There were 8 cases of LS, 50 % of them anti‐TPO+. Autoimmune disorders were found in 40 % (total) and in 87.5 % of those affected. Most common HLA markers were B*15, B*57, CW*03, CW*07, CW*18, DRB1*04, DRB1*07, DRB4*. The three latter have been previously associated with LS. Conclusion: New cases of LS and autoimmune disorders can be detected in first degree relatives of patients with LS. The presence of anti‐TPO antibodies strongly suggests autoimmune thyroiditis. There is intra‐familial association between the haplotype HLA‐B*15 ‐DRB1*04 ‐DRB4* and anti‐TPO,emphasizing their link with thyroiditis. New familial approaches might help to make clear the pathogenesis of LS and its association with autoimmune diseases. 相似文献
5.
The incidence of eye infections in a community is generally accepted as an indicator of the adequacy of water supply for their needs. However, discrepancies in the published results from various studies seem to challenge this view. We have reanalysed the published data on trachoma in relation to the most relevant indicators of water accessibility, using prevalence ratios as the single parameter for risk assessment. A definite trend emerges from this review: the incidence of infectious conjunctivitis is not sensitive to differences in water accessibility; on the other hand, a reduction in the risk of trachoma is consistently associated with better access to water. This conclusion may support the efforts of WHO and other multilateral and bilateral agencies to sustain the commitment towards the water supply sector beyond the International Drinking Water Supply and Sanitation Decade. 相似文献
6.
Rafael Cincu Juan F Martin L��zaro Jos�� Luis Capablo Liesa Jos�� Ram��n Ara Callizo 《Indian Journal of Orthopaedics》2007,41(4):395-397
Intramedullary epidermoid cysts of the spinal cord are rare tumors, especially those not associated with spinal dysraphism. About 50 cases have been reported in the literature. Of these, only seven cases have had magnetic resonance imaging (MRI) studies. We report two cases of spinal intramedullary epidermoid cysts with MR imaging. Both were not associated with spina bifida. In one patient, the tumor was located at D4 vertebral level; while in the other, within the conus medullaris. The clinical features, MRI characteristics and surgical treatment of intramedullary epidermoid cyst are presented with relevant review of the literature. 相似文献
7.
8.
Aldo Cunha Medeiros Irami Araújo Filho Vítor Brasil Medeiros Laíza Araújo Mohana Pinheiro Flávio Henrique Miranda Araújo Freire Italo Medeiros Azevedo José Brand?o-Neto 《Journal of investigative surgery》2007,20(1):41-48
After total gastrectomy, the ileocecal graft may act as a reservoir and protect against reflux but give rise to transposition of the ileum and cause possible changes in bile acid metabolism and nutrition. This study compared the ileocecal graft and jejunal pouch. Male Wistar rats weighing 265 +/- 22 g were submitted to sham operation (S), ileocecal interposition graft (IIG), and jejunal pouch interposition graft (JP) after total gastrectomy. Eight weeks later, the esophagus was examined for evidence of esophagitis. Nutritional biochemistry and weight profile were documented preoperatively and 8 weeks after surgery. The oral glucose tolerance test was performed. Thirty-three rats were operated on and 30 survived for 8 weeks. Esophagitis occurred in seven JP rats. Body weight was significantly higher in IIG than in JP rats (p < .05). Normal glucose tolerance to intragastric glucose load was observed in sham and operated rats. JP rats had a significant decrease in serum albumin, glucose, transferrin, hemoglobin, iron, folate, and calcium, compared to sham (p < .05). Cobalamine was significantly lower in IIG rats than in JP rats (p < .05). In the IIG and JP groups, serum/hepatic total bile acid did not differ significantly from preoperative and sham values. In conclusion, the IIG interposition graft in rats prevented esophagitis, preserved nutrition, and did not interfere with enterohepatic total bile acid circulation. 相似文献
9.
Sergio Negrin-Dastis Dominique Butenda Jacques Dorzee Jacques Fastrez Jean-Paul d��Od��mont 《Canadian respiratory journal》2007,14(4):235-237
A case of pulmonary Langerhans cell histiocytosis, proved by both lung high-resolution computed tomography and lung biopsy, is described. Following smoking cessation, lung nodules and cysts gradually disappeared on serial computed tomography scans, with complete clearance of the lesions after 12 months. The role of tobacco smoking is discussed, in detail, against the background of the literature. 相似文献
10.
A Albino-Teixeira I Azevedo D Branco W Osswald 《European journal of pharmacology》1990,179(1-2):141-149
Surgical denervation of the lateral saphenous vein of the dog causes marked extraneuronal changes, both of a morphological and functional type. In an attempt to investigate the factor(s) responsible for the trophic effects exerted by the sympathetic innervation on the dog saphenous vein we studied the effects of noradrenaline, adenosine, inosine and N-ethylcarboxamidoadenosine (NECA) on vascular tissue after sympathetic denervation. The saphenous vein was denervated using either surgical or chemical (6-hydroxydopamine, 6-OHDA) methods. Noradrenaline (0.1 microgram/kg per h), adenosine (10 micrograms/kg per h), inosine (10 micrograms/kg per h) or NECA (0.1 microgram/kg per h) were delivered continuously for 5 days through Alzet minipumps connected to the vein. 6-OHDA-induced denervation resulted in morphological changes similar to those described for surgical denervation. Smooth muscle cells and fibroblasts showed ultrastructural signs of increased synthetic activity and their size was significantly increased. In confirmation of earlier studies, constant i.v. infusions of noradrenaline did not prevent the morphological changes induced by denervation. Adenosine prevented the morphological changes induced by chemical or surgical denervation. Similarly to adenosine, infused NECA prevented the structural consequences of denervation. In contrast, inosine did not prevent the changes caused by surgical denervation. The results are compatible with an involvement of purines in the trophic effects of sympathetic innervation. Moreover, the effects of adenosine do not appear to be mediated by inosine. 相似文献