急重型病毒性脑炎并多脏器衰竭1例报道

急性病毒性脑炎常出现急性脑水肿 ,以致引起严重的意识障碍、癫痫发作 ,甚至发生脑疝致中枢衰竭而死亡。但临床合并多脏器损害者极少见。我院神经内科收治了 1例急性重症病毒性脑炎合并心、肺、肝、肾、血液、消化道等多脏器功能衰竭的病例 ,现报道如下。1　病例简介男 ,患者 ,4 8,岁 ,2 0 0 4 - 0 2 - 0 5入院 ,患者于入院前 12h无诱因出现寒战、周身关节酸痛 ,T 38 9℃ ,自服安瑞克 1包 ,体温降至 37 3℃ ,余无其他不适 ,入院前 6h突然出现意识不清 ,二便失禁 ,呼吸急促 ,伴鼾音 ,四肢强直、抽搐。约 1～ 2min可缓解 ,此后抽搐频繁发作 ,…     

大鼠局灶性脑缺血再灌注后CAD表达与细胞凋亡的关系

目的　探讨大鼠局灶性脑缺血再灌注后缺血半暗带 Caspase-3激活的 DNA酶 (CAD)基因的表达变化与细胞凋亡的关系。方法　线栓法建立大鼠大脑中动脉闭塞 (MCAO)及再通模型。应用 RT-PCR技术检测MCAO再通后不同时相缺血半暗带皮质 CAD基因的表达 ,同时利用 TU NEL法观察对应区域细胞凋亡的动态变化规律。结果　脑缺血再灌注 6h,半暗带皮质 CAD m RNA显著升高 ,密度比值为 0 .74± 0 .0 4,再灌注 2 4h达到高峰 (1.13± 0 .11)。对应各时相均可见神经细胞凋亡 ,凋亡细胞以再灌注 48h组为最高 (113 .10± 13 .88)。结论　脑缺血再灌注可致 CAD基因表达上调 ,可能参与了缺血后神经细胞凋亡过程     

急性脑梗塞脑微循环障碍研究进展

脑微循环障碍参与急性脑梗塞整个病理生理过程 ,其病因可分为血管外、血管壁、血管内三个方面。本文以内皮细胞、白细胞、血小板、凝血酶、微小纤维蛋白血栓对微循环的影响及对急性脑梗塞防治为中心进行综述     

马斯平、君刻单治疗铜绿假单胞菌性脑膜炎临床报告

报告铜绿假单胞菌性脑膜炎12例，对多种抗生素耐药，病程迁延反复，采用第四代头孢菌素头孢吡肟(马斯平)与氨曲南(君刻单)联合治疗，5—7日后即出现显效果，疗效稳定，全部治愈，无明显副作用。表明第四代头孢菌素在治疗院内难治性感染，特别是革兰氏阴性菌感染方面可发挥重要作用。     

骨髓单个核细胞移植实验性脑缺血小鼠PKH26和DAPI的双重标记

OBJECTIVE: Transplantation of stem cell shows promise as a treatment for ischemic brain. However, the ability of bone marrow mononuclear cells (BMMCs) as a therapy for ischemic brain has received little attention. We hypothesized that BMMCs could be used to treat focal ischemic brain in a mouse model. METHODS: BMMCs were harvested from BALB/c mice and then double labeled with PKH26 and DAPI. The labeled cells were subsequently infused into the tail veins of mice in which ischemic brain model had been induced by modified electric coagulation approach. 14 days after transplantation, the migration status of the cells was studied by fluorescence microscopy and the expression of proliferating cell nuclear antigen (PCNA), doublecortin (DCX) were evaluated in both groups. RESULTS: Positive cells pre-labeled by PKH26 and DAPI were found in the cortex region of ischemic hemisphere. Over 14 days of the experiment, mice were subjected to neurologic functional tests (adhesive-removal, modified neurologic severity scores) before and at 0, 1, 4, 7, and 14 days after middle cerebral artery occlusion. The data demonstrated a trend toward improved neurologic function in animals receiving BMMCs and the survival rates were not significant difference in this group. CONCLUSIONS: Taken together, these data demonstrate the effectiveness and capacity for transplantation of BMMCs therapy in murine models of focal ischemia brain. Specifically, we have demonstrated that systemically delivered BMMCs preferentially locate to and are retained by the ischemia brain and these cells foster functional improvement after cerebral ischemia.     

骨质疏松性股骨颈骨折误诊为脑梗塞1例

女,76岁.因左下肢活动不灵活3 h入院.3 h前下床后,自感左下肢无力,跌坐在地,站立不能,无明显疼痛,无恶心呕吐,无头晕头痛,无意识障碍,被家人发现后直接送入神经科病房.既往高血压病史20 a余,糖尿病史8 a,3 a前患脑梗塞,遗留左侧肢体活动障碍,但仍可行走.     

高等院校构建诚信教育体系的研究

在我国倡导构建社会主义市场经济的社会信用体系的背景下，本文提出高等院校建立诚信体系是我国社会信用体系的重要组成部分；高校诚信教育体系的建立具有紧迫性、先行性；高等院校诚信教育体系的建立是一项系统工程。     

溶栓与脑保护对大鼠脑缺血半暗带细胞凋亡的影响

在局灶性脑缺血损伤机制及其临床治疗的研究中，缺血半暗带是治疗针对的关键性靶点。由于缺血性脑损伤机制的多重性和瀑布效应。单独使用任何一种药物都难于发挥明显的疗效。因此，综合疗法特别是溶拴一脑保护综合疗法受到普遍重视。为了探讨综合疗法的应用前景。我们研究了溶拴与脑保护综合疗法对缺血半暗带细胞凋亡相关基因bcl-2、bax的影响。