线粒体自噬与肺部疾病的研究进展

线粒体自噬是选择性自噬的重要形式之一,可通过调控生物体内线粒体质量影响肺部疾病发生发展。线粒体自噬在不同的肺部疾病中发挥着不同的作用。如在特发性肺纤维化与急性肺损伤中,线粒体自噬水平过高或过低都可加重病情;而在肺动脉高压中,线粒体自噬水平过高时会产生损害效应。除此之外,在慢性阻塞性肺疾病中,线粒体自噬可调节细胞坏死以及控制细胞炎性反应。因此,深入了解线粒体自噬调控机制对肺部疾病的防治具有重要意义。     

The study of the impact by atractylenolide-1 on inflammatory cytokine,autophagy and apoptosis in alveolar macrophages of silicosis patients

<正>Objective To explore the effect of atractylenolide-1( ATL-Ⅰ) on alveolar macrophages in silicosis patients.Methods In December 2019,12 male silicosis patients treated in Beidaihe Sanatorium for Chinese Coal Miners from July to September 2019 were selected by random sampling.Their alveolar macrophages were collected and divided into control group,ATL-Ⅰ group( 100 μmol/L) and dimethyl sulfoxide( DMSO) group( 100 μmol/L).The exprossion levels of inflammatory factor interleukin-1β( IL-1β),i...