小鼠大肠腺癌诱发过程中的肠腺扩张

在小鼠大肠腺癌诱发过程中,观察大肠粘膜腺体扩张变化。肠腺扩张先于腺癌发生,与异型增生伴存,其数目在实验鼠(47％)比对照鼠(6％)有明显差别等说明肠腺扩张与诱癌过程密切相关。文中对肠腺扩张在诱癌过程中的地位进行了讨论。     

甲基硝基亚硝基胍灌胃诱发小鼠胃癌和小肠癌的观察

用较大剂量MNNG多次灌胃LACA小鼠,分阶段处死,肿瘤的最高发生率可达100％(5/5),良瘤与癌均为82％(9/11)。缩短了前胃、腺胃及小肠的诱癌时间。探讨了各部位肿瘤发生率不同的原因。     

几种镍剂对小鼠致癌作用的实验研究

应用某镍冶炼厂作业环境中存在的几种镍剂,给三种小鼠右腋皮下注射,每鼠5mg,观察62周。仅见镍精砂(主要含Ni_3S_2)有局部诱癌作用。其病理组织学表现以纤维肉瘤为主,亦见2例横纹肌肉瘤,大多数肿瘤分化差,有浸润性,个别发生肝、肺转移。此结果提示该厂环境中存在的镍精砂可能对人类也具有致癌危险性,在考虑劳保措施和职业癌的防治中应引起足够重视。     

乙基硝基亚硝基胍(ENNG)灌肠对小鼠诱癌作用及大肠腺癌酶组织化学变化的初步观察

将ENNG配成5％二甲亚砜溶液给昆明种、LACA小鼠灌肠(0.5mg/次/鼠,6次/周,ENNG最大用量分别为45mg,39mg),诱发出分化较好的大肠腺癌、肛门鳞癌。     

乙基硝基亚硝基胍灌肠对小鼠诱癌作用及大肠腺癌酶组织化学变化的初步观察

近年来,随着一些有效致癌剂的应用,实验性大肠癌的研究发展较快。目前常用的致癌剂有1,2——二甲肼(DMH)、甲基硝基亚硝基胍(MNNG)、甲基硝基脲(MNU)等。八十年代初,Kamano T等用乙基硝基亚硝基胍(N-ethyl-N′-nitro-N-nitrosoguanidine,ENNG)栓剂诱发出狗大肠癌。但所复习的文献中尚未见用ENNG诱发小鼠大肠肿瘤的报道。作者用ENNG液给小鼠灌肠诱发了大肠和肛门肿瘤,并用组化方法对大肠腺癌的酶活性变化进行了观察,现将初步结果报道如下:     

国产乙酰血卟啉和血卟啉二钠盐在体内外吸收和分布的研究

作者对国产AHP、HPD在体内外的吸收及分布进行了研究。观察到正常肝、肾,恶性肿瘤细胞均能吸收AHP、及HPD。将AHP、HPD分别注入小鼠体内后,进行6～216小时动态观察,以生化方法测其含量,最高吸收峰在6～12小时,以肝脏及恶性肿瘤含量最高,恶性肿瘤组织储留可达216小时。     

小鼠肺腺癌的形态发生和组织化学观察

在MNNG诱发小鼠肺腺癌过程中,分期处死动物,用光镜、透射电镜及酶组织化学技术观察肺腺癌的形态发生过程及多种酶活性变化,探讨了小鼠肺腺癌的形态发生及相应的代谢变化。     

岩参治疗食管上皮细胞重度增生的疗效观察(附114例临床资料分析)

本文报告用岩参治疗46例食管上皮细胞重度增生的效果。发现岩参抗炎性强,对“重增”和对慢性咽炎、食管炎、慢性胃炎均有较好的疗效。从细胞学转归和炎细胞阴转率与35例对照组相比,均有很显著的优点。治疗后一年以上进行细胞学复查,无一例癌变。     

三氯乙酸变态反应性关节炎一例报告

报道1例手指囊肿,经40％三氯乙酸约1ml,单次注射治疗后,引起以关节炎为主的Ⅲ型变态反应,并对其发生机理进行了讨论。     

绿茶对甲基硝基亚硝基胍诱发LACA小鼠肺...

Three hundred and ninety LACA mice of seven weeks old were used in 2 batches (96.4 wks and 106 wks) for studying the preventive effect of green tea on MNNG-induced lung cancers and precancerous lesions. These mice (within each batch) were randomly allocated to four groups, namely, positive control (MNNG), green tea (GT), complex (MNNG + GT), and blank control (C) group. In MNNG group, MNNG 250 micrograms) was injected intravenously every five days for seven times in each mouse; the total dosage of MNNG was 1.75mg. In GT group, according to W/W, 5% GT dust was well mixed into 95% common diet for long-term breeding. In complex group, MNNG was given as that in MNNG group and the mice were reared as those in GT group. The mice in MNNG group and in C group were all reared by common diet. The mean amount of daily intake of feed was 10g. The number of effective animals was 354. The results of experiments showed different degrees of preventive effect of green tea on MNNG-induced lung cancers and precancerous lesions in LACA mice. Green tea exerted an effect on the number of induced cancers and precancerous lesions, causing a drop of the cancerous rate from 79.75% to 13.59% and the number of lung tumor down to 1/7-1/16 that of the MNNG group, i.e. down to less than one tumor nodule per mouse.(ABSTRACT TRUNCATED AT 250 WORDS)