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Objective. The aim of this study was to detect coronary artery disease using ^99mTc-MIBI myocardial perfusion imaging in patients with valvular disease. Methods. Thirty patients with valvular disease confirmed by echocardiography underwent ^99mTc-MIBI myocardial perfusion imaging using multiSPECT lh after stress test (exercise, dipyridamole or dobutamine test) and were performed coronary angiography within 1 month before valvular operation. Results. For 29 out of the 30 patients, the results of ^99mTc-MIBI myocardial perfusion imaging were similar with those of coronary angiography, the concordance rate was 96.7 % and the negative predictabili-ty was 100%. Conclusion. ^99mTc-MIBI myocardial perfusion imaging is a reliable non-invasive method for detecting coronary artery disease in patients with valvular disease and so as to draw up suitable operation programs for them. 相似文献
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目的 探讨m d m2 、p53 基因蛋白及雄激素受体( AR) 、雌激素受体(ER) 在尿路上皮癌中的表达及意义以及 m d m2蛋白与AR 、ER 和p53 蛋白表达的相互关系。方法 采用免疫组化技术检测60 例尿路上皮癌石蜡标本。结果 m d m2 蛋白阳性率为55 .0 % ,与肿瘤分级、分期密切相关,高分化癌、浅表性癌阳性表达显著高于低分化及浸润性癌。p53 蛋白阳性率为53 .3 % ,在低分化及浸润性癌组织阳性率明显高于高分化及浅表性癌( P< 0 .05) 。AR 、ER 阳性率分别为51 .7 % 及48 .3 % ,与肿瘤分级呈正相关表达( P< 0 .05) ,与临床分期无关。男、女两性间仅AR 表达有显著差异( P< 0 .05) 。m d m 2 与AR 及ER 表达呈正相关(γ值分别为0 .4018 、0 .2249) ,与p53 表达呈负相关(γ= - 0 .4989) 。结论 提示m d m2 ,p53 、AR 及ER 均与肿瘤组织病理学有关,对尿路上皮癌的发生发展均有各自的作用。联合检测癌相关基因蛋白及性激素受体可了解尿路上皮癌多方面的生物学信息,为临床提供更有价值的预后判断指标。 相似文献
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例1 男,30岁.于1972年7月21日因左侧胸部刀刺伤15分钟急诊入院.诊断心脏刺伤,急症手术,经左胸前外侧第4肋剖胸,胸腔积血约1500ml,心包膨胀呈紫红色,心跳微弱,纵形切开心包,有大量暗红色血液及血块涌出,右心房有约2.5cm长裂口、并有血喷出.手指压迫止血时,心跳停止,立即行心脏按摩,并快 相似文献
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目的 探讨符合WHO 2004年诊断标准的多房囊性肾细胞癌(MCRCC)患者的CT特征及与其他亚型囊性肾细胞癌(CRCC)的鉴别要点.方法 依据是否符合WHO 2004年病理诊断标准将40例患者分为两组:MCRCC组及其他亚型CRCC组(CRCC组),复阅CT片,对比肿瘤直径、边界、密度、囊壁及分隔最大厚度、钙化、强化值等CT征象.采用ROC曲线法确定相关指标的临界值及诊断的特异度、灵敏度.结果 MCRCC组17例,CRCC组23例.MCRCC多表现为囊壁薄、分隔细小、无明显结节的囊性占位.囊壁及分隔最大厚度是鉴别MCRCC及其他亚型CRCC的惟一CT征象(P<0.01),其临界值为6mm,诊断的灵敏度和特异度分别为89%和75%.结论 囊壁及分隔厚度小于6 mm是鉴别MCRCC与其他亚型CRCC的主要CT征象.Abstract: Objective To determine the main CT features and the key points of differential
diagnosis of multilocular cystic renal cell carcinoma (MCRCC) classified according to 2004 WHO
pathological diagnostic criteria. Methods According to the criteria, 40 patients were divided into two
groups: MCRCC group and other subtypes of cystic renal cell carcinoma (CRCC). The CT findings were
evaluated and compared between two groups for cystic content, wall, septum, nodularity, calcification and
enhancement. ROC curve was used to determine the cut-off value of the possible CT feature which could
distinguish MCRCC from other subtypes of CRCC. Results Seventeen cases of MCRCC group and 23 cases
of CRCC group were included in this study according to the diagnostic criteria. MCRCC appeared as a well
defined multilocular cystic mass with thin wall and sepia and no expansile solid nodules. Thickness of cystic
wall and/or septum is was main CT findings to distinguish MCRCC from other subtypes of CRCC (P < 0.01 ).
The cut-off value of the thickness was 6 mm and its sensibility, specificity was 89% ,75% respectively.
Conclusion Cystic wall and/or septum with a thickness of less than 6 mm are the main CT findings to dis
tinguish MCRCC from other subtypes of CRCC. 相似文献
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