脑卒中的危险因素及其对策

在包括日本在内的发达国家，脑卒中的死亡率正在下降，但仍与恶性肿瘤和心脏疾病并列，成为主要死亡原因之一。脑卒中虽然不至于死亡，但成为躯体和智能障碍、卧床不起和痴呆的原因疾病。因此。预防脑卒中不仅是医学，还是社会的重要课题。为实现该目标，应正确了解日本人的脑卒中危险因素的状况。本文将以福冈县久山町的持续40年以上的流行病学调查（久山町研究）的结果为主介绍日本人的脑卒中危险因素。     

调节性CD4+T细胞在大鼠自发肝移植耐受中的作用

目的 探讨在肝移植的自发耐受模型中，调节性CD4^＋T细胞的免疫抑制作用机制。方法 利用近交系大鼠从Lewis（LEW）到Wistar Furth（WF）的肝移植组合，对移植后不同时期的宿主注射抗CD4的单克隆抗体（Anti-CD4mAb），然后抽血检测丙氨酸氨基转氨酶（ALT）的动态变化；并结合细胞毒性T淋巴细胞（CTL）试验了解宿主脾细胞中T细胞亚群的动态改变。结果 对肝移植自然生存的宿主注射Afiti—CD4mAb后，术后第21天、42天均能够诱导出肝损害（排斥反应），但第56天、100天以上的则未能诱导出来，且该损害能被抗CD8单克隆抗体阻断。另外CTL试验显示宿主的脾细胞中，初始型CTL前体细胞在移植56d后未能检测出来。结论 在自发性肝耐受模型中。宿主术后早期存在由CD4^＋T细胞介导的下调原始效应性T细胞的作用机制。     

Analysis thrombolysis with anticoagulation treatment for early stage of deep vein thrombosis in the lower extremities

Objective:To explore the effect of thrombolysis with anticoagulation treatment forearly stage of deep vein thrombosis of lower extremity.Methods:The clinical data of 10 patients at the early stage of deep vein thrombosis(DVT)in the lower extremuites treated by thrombolysis with anticoagulation and dispersion drugs were analyzed retrospectively.Results:The thrombolytic effect was significant.After treatment,the deep veins were recanalized without regurgitation in 75.3% of the patients.The total effective rate was 100%.Only three patients had hemorrhagic complication,but none of the patients died.Conclusion:Thrombolysis with anticoagulation treatment is an effective and safe method for DVT at the early stage.     

放射性粒子^125I植入加局部化疗治疗皮肤癌的疗效观察

目的探讨皮肤癌应用放射性粒子^125I植入加局部化疗治疗的价值。方法5例基底细胞癌和1例鳞状细胞癌及1例汗腺癌患者，根据病灶范围的大小，制定粒子治疗计划，将放射性粒子^125I植入病灶部位进行持续照射。在粒子植入术后局部使用化学药物搽敷，有2例患者同期加用全身化疗，1个月后进行临床疗效评价。结果5例肿瘤完全消退(CR)，1例部分消退(PR)，1例无变化(NC)。结论放射性粒子^125I植入加局部化疗治疗皮肤癌，近期疗效满意，治疗操作简单，损伤小，经济实惠，对缺少放射治疗设备的医院提供一种治疗皮肤恶性肿瘤的有效手段。     

铁代谢与肝癌预防

铁离子是人体中含量最大的金属元素，主要作为红细胞内的血红蛋白铁和肌肉中的肌红蛋白铁而从事分子氧的运输作用。它还存在于一切细胞之中，催化细胞内的氧化还原而形成多数的酶活性中心，并与细胞生长和凋亡等机制相关。铁离子如果在体内存在过剩，则其毒     

暴发型肝炎的治疗研究进展

暴发型肝炎的治疗研究进展铃木一幸等暴发型肝炎（暴肝，大致相当于中国分类重型肝炎之急性与亚急性病例）乃系急骤发生广泛性肝细胞坏死而引起重度肝功能障碍，出现以肝性脑病为主的肝功能衰竭症状之预后不良性疾病。在日本，本病病因９０％为肝炎病毒，１０％为药物。前...     

An experimental study of spinal cord evoked potential.

The characteristics of spinal cord-evoked potentials were investigated by using an in vitro spinal cord preparation. The spinal cord isolated from adult rats was immersed in a bathing chamber filled with oxygenated artificial cerebrospinal fluid (aCSF). The spinal cord-evoked potentials elicited by the stimulation of the spinal cord were recorded by using bipolar platinum electrodes. The potentials recorded consisted of early and late negative components (N1, N2). The inhibitory effect of lowered temperature on the N1 potential was clearly demonstrated. The oxygen deprivation of aCSF showed the higher sensitivity of N2 potential to hypoxia than that of N1. It was also possible to analyze the effects of potassium and magnesium ion concentration and pH on the evoked potentials. These results showed that the pure effects of various physiological and chemical factors on the spinal cord-evoked potentials can be analyzed by this experimental model.