全文获取类型
收费全文 | 465篇 |
免费 | 9篇 |
国内免费 | 27篇 |
专业分类
儿科学 | 14篇 |
妇产科学 | 47篇 |
基础医学 | 71篇 |
口腔科学 | 7篇 |
临床医学 | 53篇 |
内科学 | 99篇 |
皮肤病学 | 5篇 |
神经病学 | 7篇 |
特种医学 | 58篇 |
外科学 | 20篇 |
综合类 | 5篇 |
预防医学 | 12篇 |
眼科学 | 1篇 |
药学 | 54篇 |
中国医学 | 2篇 |
肿瘤学 | 46篇 |
出版年
2022年 | 4篇 |
2021年 | 7篇 |
2020年 | 7篇 |
2019年 | 7篇 |
2018年 | 11篇 |
2017年 | 4篇 |
2016年 | 3篇 |
2015年 | 6篇 |
2014年 | 10篇 |
2013年 | 13篇 |
2012年 | 14篇 |
2011年 | 14篇 |
2010年 | 9篇 |
2009年 | 14篇 |
2008年 | 18篇 |
2007年 | 30篇 |
2006年 | 17篇 |
2005年 | 12篇 |
2004年 | 21篇 |
2003年 | 8篇 |
2002年 | 20篇 |
2001年 | 13篇 |
2000年 | 5篇 |
1999年 | 14篇 |
1998年 | 23篇 |
1997年 | 15篇 |
1996年 | 13篇 |
1995年 | 10篇 |
1994年 | 13篇 |
1993年 | 15篇 |
1992年 | 7篇 |
1991年 | 11篇 |
1990年 | 3篇 |
1989年 | 11篇 |
1988年 | 14篇 |
1987年 | 10篇 |
1986年 | 9篇 |
1985年 | 9篇 |
1984年 | 5篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 2篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1978年 | 10篇 |
1977年 | 7篇 |
1976年 | 6篇 |
1975年 | 4篇 |
1973年 | 2篇 |
1972年 | 2篇 |
排序方式: 共有501条查询结果,搜索用时 15 毫秒
1.
2.
Compensation of labyrinthine lesions: effects of trigeminal neurotomy on vestibular field potentials
The aim of the research was to analyse the vestibular nuclear activity before and after the section of the 5th cranial nerve in chronically hemilabyrinthectomized guinea pigs during the stage of compensation. The animals were hemilabyrinthectomized (chloroform and vaselin oil into the right middle ear) and upon compensation (24–45 days), field potentials were recorded from the vestibular nuclei of the intact side following electrical stimulation of the ipsilateral labyrinthine receptors. Then the left trigeminal trunk was sectioned ventrally through the foramen lacerum and ovale which are fused in the guinea pig and the vestibular field potentials were again recorded for a period of 120 min. Trigeminal neurotomy modified the vestibular field potentials determining an increment in amplitude of 30–50% of N1 and N2 waves, configuration and latency remained unaltered. The dependence of vestibular compensation on trigeminal afferents is discussed on the light of reported results. 相似文献
3.
Antibiotic Use in Crohn’s Disease 总被引:3,自引:0,他引:3
Prantera C Scribano ML Berto E Zannoni F 《BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy》1997,8(4):293-306
On the assumption that bacteria in the gut may be a cause of symptoms and/or complications of Crohn's disease, various antibiotics are efficaciously employed in some affected patients. However, we do not know exactly why and how they are helpful. A possible explanation is that one or several bacterial species may have a primary role in the aetiology of Crohn's disease, but this is not supported by the data in our possession. Another hypothesis is that intestinal bacteria may cause flare-up of the disorder, either by inducing intestinal lesions or by an interaction with the immune system, but we know today that specific pathogens can cause flares only in a minority of cases. On the contrary, there is considerable evidence that the intestinal microflora and its products may amplify and perpetuate inflammation in Crohn's disease. Despite the fact that few controlled trials have been conducted, and have shown inconclusive results, antibiotics are widely employed for improving symptoms and for inducing remission of active phases. At present, a combination of metronidazole and ciprofloxacin, active against many enteric bacteria, has proved to be effective in the treatment of Crohn's disease complications. This therapy also seems to be effective in acute flares as an alternative to, or in combination with, corticosteroids. 相似文献
4.
Direct evidence for the involvement of carbohydrate sequences in human sperm-zona pellucida binding 总被引:2,自引:0,他引:2
Several lines of evidence indicate that mammalian fertilization is
initiated via a binding process that is dependent upon the recognition of
oligosaccharide sequences associated with zona pellucida (ZP)
glycoproteins. Here, specific chemical and enzymatic methods were employed
to modify human ZP and to test their effects on sperm binding in the
hemizona assay system (HZA). Periodate oxidation of human ZP under very
mild conditions (10 min, 0 degrees C, 1 mM sodium m- periodate) that
attacks only terminal sialic acid resulted in a 30% loss of human sperm
binding in the HZA [hemizona index (HZI) = 70.2 +/- 10.9, n = 22; P <
0.05]. Periodate oxidation under mild conditions (1 h, 23 degrees C, 10 mM
sodium m-periodate) caused a 40% decrease in binding (HZI = 60.8 +/- 10.3;
n = 24; P< 0.01). Treatment of human ZP with neuraminidase caused a
substantial increase in sperm binding to human ZP (HZI = 297 +/- 45, n =
22; P < 0.01). These findings indicate that there are sialic acid
dependent binding sites coexisting with binding sites that are obscured by
sialic acid. To determine the periodate sensitivity of these obscured
sites, hemizona were first digested with neuraminidase and subsequently
subjected to mild periodate oxidation. The combined enzymatic and chemical
treatments caused a 79% decrease in sperm binding compared to control
hemizona (HZI = 20.7 +/- 4.4, n = 16; P < 0.001). Human sperm-ZP
interaction was also increased by digestion of human ZP with
endo-beta-galactosidase (HZI = 710 +/- 232, n = 14; P < 0.01),
indicating that potential binding sites for spermatozoa are also obscured
by lactosaminoglycan sequences. These studies support a definitive role for
the involvement of ZP-associated glycans in the binding of human
spermatozoa to oocytes.
相似文献
5.
Human decay accelerating factor transgenic pigs for xenotransplantation obtained by sperm-mediated gene transfer 总被引:1,自引:0,他引:1
6.
7.
Ferrandina G Martinelli E Petrillo M Prisco MG Zucconi A Santaguida S Zannoni G Scambia G Ferlini C 《Gynecologic oncology》2008,111(2):237-243
ObjectiveThe aim of the study was to investigate the potential clinical relevance of immunohistochemically assessed RON expression in a large, single institution series of primary untreated advanced ovarian cancer patients.MethodsImmunohistochemical analysis was performed by using the polyclonal rabbit anti-RON-β antibody (C-20, clone sc-322, Santa Cruz, California). Results were expressed as the total proportion of immunostained tumor cells (RON positivity), or the percentage of cells showing strong staining of RON expression (H-RON positivity).ResultsIn the overall series RON positive immunoreaction was observed in 103/141 cases, while H-Ron positivity was detected in 577141 (40.4%) cases. No association between RON and H-RON expression with response to first-line treatment was documented. During the follow up period, progression and death of disease were observed in 111 (78.7%) and 76 (53.9%) cases, respectively. Cases with strong H-RON expression has a shorter overall survival (median = 35 months) than cases with low RON levels (median = 59 months) (X2 = ? 2.1, p value = 0.032). In multivariate analysis, only platinum resistance, and extent of residual tumor retained an independent negative prognostic role for OS, with the percentages of H-RON positively immunostained cells showing a borderline statistical significance (p value = 0.0643). The unfavourable role of elevated percentages of H-RON expression was maintained only in the subgroup of platinum resistant recurrent ovarian cancer patients (X2 = 3.89, p value = 0.048) compared to the platinum sensitive ones (X2 = 1.98, p value = 0.16).ConclusionsThe assessment of RON expression deserves further attention as a parameter helpful to identify poor prognosis ovarian cancer patients potentially candidates to investigational agents. 相似文献
8.
BACKGROUND: Endometrial ossification is a rare disease. More than 80% of cases occur after pregnancy, but it has been observed in patients with a history of endometritis, dilation and curettage, and metabolic disorders. CASE: A 42-year-old woman presented with osseous metaplasia of both the endometrium and ovaries. At laparoscopy both adnexa were covered with adhesions and were adherent to the posterior wall of the uterus. Following adhesiolysis, calcified nodules were removed from both ovaries with biopsy forceps. Endometrial bone tissue was removed by hysteroscopic resection. CONCLUSION: To our knowledge, this is the first reported case of osseous metaplasia of both the endometrium and ovaries since all cases described to date in the literature involved only the uterine cavity. Conservative management with endoscopic surgery is effective. 相似文献
9.
10.