全文获取类型
收费全文 | 18250篇 |
免费 | 779篇 |
国内免费 | 51篇 |
专业分类
耳鼻咽喉 | 560篇 |
儿科学 | 1245篇 |
妇产科学 | 607篇 |
基础医学 | 1748篇 |
口腔科学 | 857篇 |
临床医学 | 1406篇 |
内科学 | 3219篇 |
皮肤病学 | 502篇 |
神经病学 | 1304篇 |
特种医学 | 659篇 |
外科学 | 3975篇 |
综合类 | 108篇 |
一般理论 | 6篇 |
预防医学 | 624篇 |
眼科学 | 521篇 |
药学 | 1135篇 |
中国医学 | 81篇 |
肿瘤学 | 523篇 |
出版年
2023年 | 202篇 |
2022年 | 282篇 |
2021年 | 449篇 |
2020年 | 270篇 |
2019年 | 328篇 |
2018年 | 538篇 |
2017年 | 424篇 |
2016年 | 528篇 |
2015年 | 497篇 |
2014年 | 654篇 |
2013年 | 1029篇 |
2012年 | 1246篇 |
2011年 | 1395篇 |
2010年 | 779篇 |
2009年 | 479篇 |
2008年 | 892篇 |
2007年 | 1110篇 |
2006年 | 1077篇 |
2005年 | 1189篇 |
2004年 | 1050篇 |
2003年 | 948篇 |
2002年 | 865篇 |
2001年 | 467篇 |
2000年 | 519篇 |
1999年 | 358篇 |
1998年 | 160篇 |
1997年 | 124篇 |
1996年 | 105篇 |
1995年 | 78篇 |
1994年 | 66篇 |
1993年 | 45篇 |
1992年 | 45篇 |
1991年 | 48篇 |
1990年 | 44篇 |
1989年 | 29篇 |
1988年 | 36篇 |
1987年 | 46篇 |
1986年 | 39篇 |
1985年 | 53篇 |
1984年 | 27篇 |
1983年 | 42篇 |
1982年 | 40篇 |
1981年 | 29篇 |
1980年 | 25篇 |
1979年 | 37篇 |
1978年 | 37篇 |
1977年 | 25篇 |
1976年 | 37篇 |
1975年 | 24篇 |
1974年 | 28篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Rafiye Ciftciler Haluk Demiroglu Yahya Buyukasık Elifcan Aladag Salih Aksu Ibrahim C. Haznedaroglu Nilgun Sayınalp Osman Ozcebe Umit Yavuz Malkan Hakan Goker 《Clinical Lymphoma, Myeloma & Leukemia》2019,19(3):177-182
Background
Refractory acute myeloid leukemia (AML) includes AML includes failure of disease to respond to standard induction chemotherapy, relapse within 6 months after first CR, and 2 or more relapses. The outcome of these patients is usually very poor; only a small proportion can be rescued by allogenic hematopoietic stem-cell transplantation (allo-HSCT). The aim of this study was to evaluate the efficacy and feasibility of allo-HSCT in patients with refractory AML.Patients and Methods
We retrospectively analyzed the clinical outcome of 91 patients who were diagnosed with treatment-refractory AML at Hacettepe University Hospital between January 2002 and June 2018. Patients' disease status included refractory AML, defined as failure to respond to standard induction chemotherapy and relapse within 6 months after first complete remission.Results
The median follow-up was 12 months (range, 0.5-184 months) for the entire group. Kaplan-Meier estimates of the 3-year overall survival for patients who underwent allo-HSCT and patients who received only salvage chemotherapy were 67% and 12%, respectively. Additionally, the Kaplan-Meier estimates of 5-year overall survival for patients who underwent allo-HSCT and patients who received only salvage chemotherapy were 44% and 4%, respectively (P < .001). Complete remission was obtained in 25 patients (83.3%) who underwent allo-HSCT; however, the disease of only 3 patients (3.8%) exhibited complete response after salvage chemotherapy.Conclusion
Allo-HSCT is still the best-known treatment option with curative potential in patients with treatment-refractory AML. Therefore, all efforts should be made in an attempt to find a suitable matched donor in order to perform allo-HSCT. 相似文献2.
3.
Bielik Peter Bonczek Ondřej Krejčí Přemysl Zeman Tomáš Izakovičová-Hollá Lydie Šoukalová Jana Vaněk Jiří Vojtěšek Bořivoj Lochman Jan Balcar Vladimir J. Šerý Omar 《Clinical oral investigations》2022,26(12):7045-7055
Clinical Oral Investigations - The aim of this study was the analysis of WNT10A variants in seven families of probands with various forms of tooth agenesis and self-reported family history of... 相似文献
4.
Increased arterial stiffness in young normotensive patients with Turner syndrome: associations with vascular biomarkers 下载免费PDF全文
5.
6.
7.
8.
Irmak Karaca Suzan Güven Yılmaz Melis Palamar Halil Ateş 《Ocular immunology and inflammation》2020,28(6):947-951
ABSTRACT
Purpose
To investigate the effect of 1% tropicamide on anterior chamber aqueous flare (ACAF) measurements acquired with laser flare meter in patients with pseudoexfoliation. 相似文献9.
Mehmet Varol Kadriye Benkli Ayşe T. Koparal Rakibe B. Bostancıoğlu 《Drug and chemical toxicology》2019,42(4):436-443
Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. A series of mononuclear gold (III) and platinum (II) complexes based on boronated phenylalanine (BPA) were designed and synthesized using 4,4’-dimethyl-2,2’-dipyridyl (L1) or 1,10-phenanthroline-5,6-dion (L2) ligands to obtain promising anticancer drug candidates. Proton nuclear magnetic resonance, infrared, mass spectrometry, and elemental analyses were utilized for chemical characterizations. Cell viability, cancer cell colony formation, endothelial tube formation, and cytoskeleton staining assays were performed using A549 lung adenocarcinoma and human umbilical vein endothelial cells (HUVECs) to investigate preliminary pharmacological activities. L1-based platinum (II) complex (BPA-L1-Pt) was the most promising complex, and has similar activity with the approved chemotherapy drug cis-platinum. Half maximal inhibitory concentration values for BPA-L1-Pt were 9.15 µM on A549s and 16.61 µM on HUVECs; the values for cis-platinum were 5.24 µM on A549s and 23.14 µM on HUVECs. Consequently, further synthesis studies should be performed to boost the cancer cell selectivity feature of BPA by varying metal and ligand types. 相似文献
10.
An important part of fundamental research in catalysis is based on theoretical and modeling foundations which are closely connected with studies of single-crystalline catalyst surfaces. These so-called model catalysts are often prepared in the form of epitaxial thin films, and characterized using advanced material characterization techniques. This concept provides the fundamental understanding and the knowledge base needed to tailor the design of new heterogeneous catalysts with improved catalytic properties. The present contribution is devoted to development of a model catalyst system of CeO2 (ceria) on the Cu(111) substrate. We propose ways to experimentally characterize and control important parameters of the model catalyst—the coverage of the ceria layer, the influence of the Cu substrate, and the density of surface defects on ceria, particularly the density of step edges and the density and the ordering of the oxygen vacancies. The large spectrum of controlled parameters makes ceria on Cu(111) an interesting alternative to a more common model system ceria on Ru(0001) that has served numerous catalysis studies, mainly as a support for metal clusters. 相似文献