收费全文 | 8671篇 |
免费 | 545篇 |
国内免费 | 63篇 |
耳鼻咽喉 | 81篇 |
儿科学 | 215篇 |
妇产科学 | 166篇 |
基础医学 | 1348篇 |
口腔科学 | 248篇 |
临床医学 | 629篇 |
内科学 | 2236篇 |
皮肤病学 | 348篇 |
神经病学 | 759篇 |
特种医学 | 192篇 |
外科学 | 866篇 |
综合类 | 38篇 |
一般理论 | 1篇 |
预防医学 | 325篇 |
眼科学 | 263篇 |
药学 | 660篇 |
中国医学 | 35篇 |
肿瘤学 | 869篇 |
2023年 | 56篇 |
2022年 | 100篇 |
2021年 | 219篇 |
2020年 | 115篇 |
2019年 | 227篇 |
2018年 | 226篇 |
2017年 | 177篇 |
2016年 | 227篇 |
2015年 | 223篇 |
2014年 | 302篇 |
2013年 | 358篇 |
2012年 | 586篇 |
2011年 | 631篇 |
2010年 | 362篇 |
2009年 | 308篇 |
2008年 | 512篇 |
2007年 | 585篇 |
2006年 | 574篇 |
2005年 | 570篇 |
2004年 | 534篇 |
2003年 | 476篇 |
2002年 | 476篇 |
2001年 | 146篇 |
2000年 | 100篇 |
1999年 | 137篇 |
1998年 | 108篇 |
1997年 | 84篇 |
1996年 | 64篇 |
1995年 | 44篇 |
1994年 | 53篇 |
1993年 | 41篇 |
1992年 | 66篇 |
1991年 | 51篇 |
1990年 | 64篇 |
1989年 | 58篇 |
1988年 | 49篇 |
1987年 | 39篇 |
1986年 | 32篇 |
1985年 | 34篇 |
1984年 | 28篇 |
1983年 | 25篇 |
1982年 | 14篇 |
1980年 | 13篇 |
1979年 | 19篇 |
1978年 | 18篇 |
1974年 | 13篇 |
1972年 | 12篇 |
1971年 | 12篇 |
1969年 | 12篇 |
1967年 | 14篇 |
Research design and methods: This multicenter, open-label, single-group, prospective interventional study evaluated changes in total gait-related scores of the Part II/III Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) and Freezing of Gait Questionnaire (FOG-Q) in 31 Parkinson’s disease patients treated with istradefylline. Gait analysis by portable gait rhythmogram was performed.
Results: MDS-UPDRS Part III gait-related total scores significantly decreased at Weeks 4–12 from baseline with significant improvements in gait, freezing of gait, and postural stability. Significant decreases in MDS-UPDRS Part II total scores and individual item scores at Week 12 indicated improved daily living activities. At Week 12, there were significant improvements in FOG-Q, new FOG-Q, and overall movement per 48 h measured by portable gait rhythmogram. Adverse events occurred in 7/31 patients.
Conclusions: Istradefylline improved gait disorders in Parkinson’s disease patients complicated with freezing of gait, improving their quality of life. No unexpected adverse drug reactions were identified.
Trial registration: UMIN-CTR (UMIN000020288). 相似文献
Introduction
Several studies demonstrated that simulator-acquired skill transfer to the operating room is incomplete. Our objective was to identify trainee characteristics that predict the transfer of simulator-acquired skill to the operating room.Methods
Trainees completed baseline assessments including intracorporeal suturing (IS) performance, attentional selectivity, self-reported use of mental skills, and self-reported prior clinical and simulated laparoscopic experience and confidence. Residents then followed proficiency-based laparoscopic skills training, and their skill transfer was assessed on a live-anesthetized porcine model. Predictive characteristics for transfer test performance were assessed using multiple linear regression.Results
Thirty-eight residents completed the study. Automaticity, attentional selectivity, resident perceived ability with laparoscopy and simulators, and post-training IS performance were predictive of IS performance during the transfer test.Conclusions
Promoting automaticity, self-efficacy, and attention selectivity may help improve the transfer of simulator-acquired skill. Mental skills training and training to automaticity may therefore be valuable interventions to achieve this goal. 相似文献Background
There were few studies assessed the postoperative sarcopenia in patients with cancers. The objective of present study was to assess whether postoperative development of sarcopenia could predict a poor prognosis in patients with adenocarcinoma of esophagogastric junction, (AEG) and upper gastric cancer (UGC).Methods
Patients with AEG and UGC who were judged as non-sarcopenic before surgery were reassessed the presence of postoperative development of sarcopenia 6 months after surgery. Patients were divided into the development group or non-development group, and clinicopathological factors and prognosis between these two groups were analyzed.Results
The 5-year overall survival rates were significantly poorer in the development group than non-development group (68.0% vs. 92.6%, P?=?0.0118). Multivariate analyses showed that postoperative development of sarcopenia was an independent prognostic factor for poor overall survival (P?=?0.0237).Conclusions
Postoperative development of sarcopenia was associated with a poor prognosis in patients with AEG and UGC. 相似文献Methods: Cardiac surgical or neurosurgical 103 patients (65 men and 39 women; aged 63 +/- 14 yr) were studied. TOI and regional cerebral oxygen saturation (rSO2) (INVOS 4100; Somanetics, Troy, MI) were measured sequentially on patients in a resting state. The t-skull and a-CSFL were calculated using computed tomographic image slices of the head corresponding with the position of near-infrared spectroscopy sensors. The effects of these two factors, hemoglobin concentration and mean arterial pressure, on TOI and rSO2 values were evaluated by linear regression analysis.
Results: Simple linear regression analysis showed that mean arterial pressure (r = 0.27, P = 0.008), t-skull (r = 0.22, P = 0.034), a-CSFL (0.26, P = 0.012), and hemoglobin concentration (r = 0.42, P < 0.0001) were significant determinants of rSO2. Multiple linear regression analysis showed that hemoglobin concentration (r = 0.34, P < 0.001), a-CSFL (r = -0.252, P = 0.012), and t-skull (r = 0.22, P = 0.037) were significant determinants of rSO2. On the other hand, simple and multiple linear regression analysis showed that there was no significant determinant of TOI. 相似文献