全文获取类型
收费全文 | 11240篇 |
免费 | 660篇 |
国内免费 | 54篇 |
专业分类
耳鼻咽喉 | 58篇 |
儿科学 | 344篇 |
妇产科学 | 400篇 |
基础医学 | 1490篇 |
口腔科学 | 285篇 |
临床医学 | 816篇 |
内科学 | 2562篇 |
皮肤病学 | 289篇 |
神经病学 | 858篇 |
特种医学 | 461篇 |
外科学 | 1506篇 |
综合类 | 46篇 |
一般理论 | 1篇 |
预防医学 | 822篇 |
眼科学 | 323篇 |
药学 | 868篇 |
中国医学 | 13篇 |
肿瘤学 | 812篇 |
出版年
2023年 | 55篇 |
2022年 | 106篇 |
2021年 | 203篇 |
2020年 | 134篇 |
2019年 | 203篇 |
2018年 | 231篇 |
2017年 | 182篇 |
2016年 | 182篇 |
2015年 | 212篇 |
2014年 | 268篇 |
2013年 | 350篇 |
2012年 | 603篇 |
2011年 | 531篇 |
2010年 | 295篇 |
2009年 | 294篇 |
2008年 | 550篇 |
2007年 | 554篇 |
2006年 | 563篇 |
2005年 | 542篇 |
2004年 | 590篇 |
2003年 | 502篇 |
2002年 | 491篇 |
2001年 | 399篇 |
2000年 | 427篇 |
1999年 | 362篇 |
1998年 | 128篇 |
1997年 | 104篇 |
1996年 | 142篇 |
1995年 | 97篇 |
1994年 | 73篇 |
1993年 | 65篇 |
1992年 | 241篇 |
1991年 | 234篇 |
1990年 | 208篇 |
1989年 | 199篇 |
1988年 | 200篇 |
1987年 | 145篇 |
1986年 | 140篇 |
1985年 | 141篇 |
1984年 | 116篇 |
1983年 | 89篇 |
1981年 | 48篇 |
1979年 | 66篇 |
1978年 | 55篇 |
1976年 | 47篇 |
1975年 | 60篇 |
1974年 | 52篇 |
1973年 | 61篇 |
1972年 | 44篇 |
1970年 | 42篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
4.
Is it possible to make a diagnosis of raw,heated, and baked egg allergy in children using cutoffs? A systematic review
下载免费PDF全文
![点击此处可从《Pediatric allergy and immunology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
5.
M Vitacca M Paneroni L Bianchi E Clini A Vianello P Ceriana L Barbano B Balbi S Nava 《The European respiratory journal》2006,27(2):343-349
The present study compared four different sites and conditions for the measurement of maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) in 38 spontaneous breathing tracheotomised patients. Of the patients, 28 had chronic obstructive pulmonary disease (COPD). The four different conditions were: 1) through a cuff inflated cannula (condition A); 2) through the mouth with a deflated cannula (condition B); 3) through the mouth with a phonetic uncuffed cannula (condition C); and 4) through the mouth after stoma closure (condition D). Five trials in each condition were performed using a standardised method. The measurement of both MIP and MEP differed significantly depending on the condition of measurement. MIP taken in condition A was significantly higher when compared with conditions B, C and D. MEP in condition A was significantly higher when compared with condition B and D. In condition A the highest frequency of the best measurement of MIP and MEP was observed at the fourth and fifth effort, respectively. The same results were obtained after the selection of only COPD patients. In conclusion, respiratory muscle assessment differs significantly depending on measurement condition. Measurement through inflated cannula tracheotomy yields higher values of both maximal inspiratory and maximal expiratory pressure. 相似文献
6.
Dysregulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients 总被引:3,自引:1,他引:2
Massaia M; Borrione P; Attisano C; Barral P; Beggiato E; Montacchini L; Bianchi A; Boccadoro M; Pileri A 《Blood》1995,85(12):3679-3687
We have previously reported the presence of activated (HLA-DR+) T cells in multiple myeloma (MM) patients. These cells produce high amounts of interleukin (IL)-2 and interferon (IFN)-gamma and generate a potent antiplasma cell activity after appropriate in vitro stimulation, but they are unable in vivo to hold in check the disease. Activated T cells are highly susceptible to apoptosis, a form of programmed cell death involved in the modulation of immune responses and regulated by molecules such as Fas (CD95) and bcl-2. The aim of this study was to determine the expression of Fas and bcl-2 antigens and the susceptibility to apoptosis in T cells of MM patients. Fas+ cells were significantly higher, whereas bcl-2+ cells were significantly lower in MM patients than in the controls. MM patients with the highest number of HLA-DR+ T cells showed the highest Fas and the lowest bcl-2 expression. Two-color cytofluorometric analysis confirmed in individual cells that HLA-DR+ T cells coexpressed Fas and lacked bcl-2. Susceptibility to apoptosis was then investigated to evaluate the consequence of dysregulated Fas and bcl-2 expression. The percentage of apoptotic cells after incubation in medium alone (spontaneous apoptosis) or in the presence of methylprednisolone (MP) or anti-Fas monoclonal antibody (triggered apoptosis) was significantly higher in MM and mainly restricted to HLA-DR+ T cells. Spontaneous apoptotosis was reverted by exogenous IL-2. In conclusion, MM T cells have a dysregulated expression of Fas and bcl-2 antigens that is associated with an enhanced susceptibility to apoptosis. These data may unravel a novel mechanism by which activated MM T cells are weakened in their ability to exert an effective antitumor activity in vivo. 相似文献
7.
8.
P Tugwell L Hart G Kraag A Park C Dok F Bianchi C Goldsmith W W Buchanan 《The Journal of rheumatology》1984,11(4):457-461
A crossover double-blind controlled trial was performed on 36 patients with rheumatoid arthritis to assess the necessity for serum salicylate monitoring in determining optimal dosage. There was no clinically or statistically significant increase in the clinical improvement of patients associated with serum monitoring but potentially toxic serum levels occurred without tinnitus when serum monitoring was not used. 相似文献
9.
10.
D Puluszézak A Bianchi J C Cazin M Cazin 《Methods and findings in experimental and clinical pharmacology》1991,13(6):419-425
A detailed examination of quantitative relationships of pharmacological action with plasma and tissue concentrations of indomethacin has been undertaken in the rat, after single oral administration of two sustained release preparations. In this study, drug was assayed by high performance liquid chromatography, whereas antiinflammatory response was assessed through the carrageenin-induced edema test. Significant linear correlations (p less than 0.001) were found between logarithmically transformed percent inhibition of edema and logarithmically transformed plasma, as well as tissue levels of indomethacin. However, the lack of significance for partial correlation regarding tissue concentration, contrary to plasma concentration, suggests that pharmacological response is more closely related to the latter, indicating that antidematous effect is mediated via the circulating drug rather than a local action in target tissues. This assumption is further discussed from the equivalence point of view. The relevance of this type of study in the case of topical administration of indomethacin is addressed as well. Taking into account the predictive value of the rat paw edema test for clinical efficacy, relationships similar to those observed are to be expected in man. The high correlation existing between plasma concentration of indomethacin and its pharmacological effect justifies the development and use of sustained release preparations in order to improve the outcome of treatment with this nonsteroidal antiinflammatory drug. 相似文献