全文获取类型
收费全文 | 779篇 |
免费 | 59篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 19篇 |
妇产科学 | 14篇 |
基础医学 | 119篇 |
口腔科学 | 27篇 |
临床医学 | 43篇 |
内科学 | 110篇 |
皮肤病学 | 15篇 |
神经病学 | 24篇 |
特种医学 | 12篇 |
外科学 | 83篇 |
综合类 | 17篇 |
一般理论 | 1篇 |
预防医学 | 30篇 |
眼科学 | 10篇 |
药学 | 56篇 |
中国医学 | 2篇 |
肿瘤学 | 235篇 |
出版年
2024年 | 1篇 |
2023年 | 9篇 |
2022年 | 15篇 |
2021年 | 30篇 |
2020年 | 21篇 |
2019年 | 22篇 |
2018年 | 31篇 |
2017年 | 26篇 |
2016年 | 30篇 |
2015年 | 35篇 |
2014年 | 54篇 |
2013年 | 51篇 |
2012年 | 72篇 |
2011年 | 63篇 |
2010年 | 32篇 |
2009年 | 30篇 |
2008年 | 64篇 |
2007年 | 39篇 |
2006年 | 33篇 |
2005年 | 34篇 |
2004年 | 27篇 |
2003年 | 21篇 |
2002年 | 21篇 |
2001年 | 7篇 |
2000年 | 11篇 |
1999年 | 10篇 |
1998年 | 5篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 4篇 |
1992年 | 1篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1983年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1969年 | 1篇 |
1968年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有838条查询结果,搜索用时 15 毫秒
1.
Suraj Kumar Kulkarni Nagaraja Moorthy Rangaraj Ramalingam 《Echocardiography (Mount Kisco, N.Y.)》2019,36(3):598-601
Antiphospholipid antibody syndrome (APLS) is a rare disorder characterized by a hypercoagulable state. Manifestations include arterial or venous thrombosis, recurrent fetal wastage, coronary artery disease, valvular heart disease, dilated cardiomyopathy, pulmonary artery hypertension, and intracardiac thrombus. Most commonly mitral valve is affected followed by aortic and then tricuspid valve. In this report, a rare case of spontaneous aortic thrombosis with tricuspid stenosis uncomplicated by other valve lesions is presented with clinical and echocardiographic studies and computed tomographic images. 相似文献
2.
D K Srinivasa A Sahai S B Rotti M B Soudarssanane M Danabalan R N Sahoo K A Narayan G Ramalingam S Srinivasan S Mahadevan B V Bhat P Nalini 《Journal of epidemiology and community health》1997,51(4):443-448
STUDY OBJECTIVES: To assess the poliomyelitis trend, including study of the epidemiological features, and to correlate this with the immunisation coverage of infants. DESIGN: Three annual lameness surveys in children aged 0-60 months employing cluster sampling methods and a series of five cross sectional surveys of immunisation coverage in children aged 12-23 months of age were undertaken. SETTING: Pondicherry, India, 1988-92. SUBJECTS: More than 10,000 children in the age group of 0-60 months took part in the three annual lameness surveys and samples of 210 children aged 12-23 months were covered each year in immunisation coverage surveys. MEASUREMENTS AND MAIN RESULTS: Altogether 50 of 11,461, 24 of 10,093, and 17 of 11,218 children surveyed during 1989, 1990, and 1991 respectively had become lame as a result of poliomyelitis, giving prevalences of 4.4, 2.4, and 1.5 per 1000 children for the three surveys. The corrected prevalences of poliomyelitis were 5.9, 3.2, and 2.0 per 1000 children during 1989, 1990, and 1991 respectively. The proportion of cases aged up to 36 months fell from 48% in 1989 to 12.5% in 1990 and 6% in 1991. The age at onset was less than 1 year in most. The median age at onset was 10.7 months. About 54% of the affected children had received three doses of oral poliomyelitis vaccine (OPV) before the onset of paralysis. In 1988 immunisation coverage for the third dose of OPV was 91% and in 1992 it was 97.6%. The drop out rate for the first versus the third dose of OPV fell from 6.3 in 1988 to 1.9% in 1992. CONCLUSION: Three successive annual lameness surveys showed that poliomyelitis was declining between 1989 and 1991. Five immunisation coverage surveys conducted from 1988 to 1992 showed high initial coverage followed by an improvement in the form of almost universal coverage for OPV. 相似文献
3.
Kannangai R Ramalingam S Vijayakumar TS Vincent AA Abraham OC Subramanian S Rupali P Mathai D Jesudason MV Sridharan G 《Indian journal of medical microbiology》2003,21(4):274-276
Currently, antiretroviral therapy has become more affordable even in developing countries and it is being used in India. Fifteen HIV-1 infected individuals, who were on highly active antiretroviral therapy (HAART), were followed up for an average period of one year. The plasma viral load and CD4+ T cell estimation done at mean intervals of 5 months and 11 months after initiation of therapy showed a good response to therapy in 14 (93%) individuals. 相似文献
4.
Rapid particle agglutination test for human immunodeficiency virus: hospital-based evaluation 总被引:3,自引:0,他引:3 下载免费PDF全文
Ramalingam S Kannangai R Raj A A Jesudason MV Sridharan G 《Journal of clinical microbiology》2002,40(4):1553-1554
The performance of a rapid particle agglutination test for human immunodeficiency virus (HIV) (Capillus HIV type 1 [HIV-1]/HIV-2) on hospital samples is compared with enzyme-linked immunosorbent assays. The test had a sensitivity and specificity of 99 and 98.9%, respectively. In addition, the test was reactive on plasma samples from all individuals infected with HIV-1 subtype C. This test can safely be used for voluntary counseling and testing in India. 相似文献
5.
Immunoglobulin G, A, and M Responses in Serum and Circulating Immune Complexes Elicited by the 16-Kilodalton Antigen of Mycobacterium tuberculosis 下载免费PDF全文
Alamelu Raja K. R. Uma Devi B. Ramalingam Patrick J. Brennan 《Clinical and Vaccine Immunology : CVI》2002,9(2):308-312
The 16-kDa cytosolic antigen of M. tuberculosis was purified to homogeneity by molecular sieving chromatography, and the diagnostic potential of the antigen was evaluated in various categories of patients by enzyme-linked immunosorbent assay (ELISA). The immunoglobulin G (IgG), IgA, and IgM antibody levels to 16-kDa antigen were estimated in the two polar groups, namely, smear- and culture-positive pulmonary tuberculosis (S+C+) patients and healthy subjects (HS). Sensitivities of 62, 52 and 11% with specificities of 100, 97, and 95% were obtained for the three isotypes, respectively. The total number of positives by a combination of the three isotypes was analyzed in the polar groups, and the sensitivity improved to 83% with a specificity of 93%. Even when a combination of IgG and IgA alone was considered, the sensitivity was 82% with a specificity of 97%. Polyethylene glycol precipitation of the circulating immune complex (CIC) in sera was carried out. The CIC-bound antibodies to 16-kDa antigen were assessed by ELISA in the S+C+, S−C+, and S−C− categories of patients. Measuring the IgG-IgA-IgM combination positivities of the CIC-bound antibodies gave sensitivities of 97.5, 100, and 45.3%, respectively. The specificity of the assay with these combinations was maintained at 95.4%. 相似文献
6.
Reports about the effects of ascorbate (vitamin C) on cultured cells are confusing and conflicting. Some authors show inhibition of cell death by ascorbate, whereas others demonstrate that ascorbate is cytotoxic. In this report, using three different cell types and two different culture media (Dulbecco's modified Eagle's medium and RPMI 1640), we show that the toxicity of ascorbate is due to ascorbate-mediated production of H2O2, to an extent that varies with the medium used to culture the cells. For example, 1 mM ascorbate generates 161 +/- 39 microM H2O2 in Dulbecco's modified Eagle's medium and induces apoptosis in 50% of HL60 cells, whereas in RPMI 1640 only 83 +/- 17 microM H2O2 is produced and no apoptosis is detected. Apoptosis is prevented by catalase, and direct addition of H2O2 at the above concentration to the cells has similar effects to ascorbate. These results show that ascorbate itself is not toxic to the cell lines used and that effects of ascorbate in vivo cannot be predicted from studies on cultured cells. The ability of ascorbate to interact with different cell culture media to produce H2O2 at different rates could account for many or all of the conflicting results obtained using ascorbate in cultured cell assays. 相似文献
7.
8.
9.
Esaki Muthu Shankar Ramachandran Vignesh Kailapuri G Murugavel Pachamuthu Balakrishnan Ramalingam Sekar Charmaine AC Lloyd Suniti Solomon Nagalingeswaran Kumarasamy 《AIDS research and therapy》2007,4(1):1-7
Background
CD4+ T lymphocyte (CD4) cell count testing is the standard method for determining eligibility for antiretroviral therapy (ART), but is not widely available in sub-Saharan Africa. Total lymphocyte counts (TLCs) have not proven sufficiently accurate in identifying subjects with low CD4 counts. We developed clinical algorithms using TLCs, hemoglobin (Hb), and body mass index (BMI) to identify patients who require ART. 相似文献10.
Ramalingam?Saravanan Leelavinothan?PariEmail author 《BMC complementary and alternative medicine》2005,5(1):14