全文获取类型
收费全文 | 5191篇 |
免费 | 216篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 85篇 |
儿科学 | 121篇 |
妇产科学 | 207篇 |
基础医学 | 555篇 |
口腔科学 | 58篇 |
临床医学 | 398篇 |
内科学 | 1358篇 |
皮肤病学 | 88篇 |
神经病学 | 736篇 |
特种医学 | 172篇 |
外科学 | 711篇 |
综合类 | 7篇 |
一般理论 | 2篇 |
预防医学 | 164篇 |
眼科学 | 143篇 |
药学 | 279篇 |
中国医学 | 22篇 |
肿瘤学 | 330篇 |
出版年
2023年 | 47篇 |
2022年 | 90篇 |
2021年 | 151篇 |
2020年 | 101篇 |
2019年 | 108篇 |
2018年 | 147篇 |
2017年 | 103篇 |
2016年 | 123篇 |
2015年 | 131篇 |
2014年 | 196篇 |
2013年 | 243篇 |
2012年 | 385篇 |
2011年 | 372篇 |
2010年 | 214篇 |
2009年 | 213篇 |
2008年 | 335篇 |
2007年 | 298篇 |
2006年 | 281篇 |
2005年 | 299篇 |
2004年 | 243篇 |
2003年 | 247篇 |
2002年 | 216篇 |
2001年 | 85篇 |
2000年 | 87篇 |
1999年 | 82篇 |
1998年 | 51篇 |
1997年 | 31篇 |
1996年 | 37篇 |
1995年 | 38篇 |
1994年 | 33篇 |
1993年 | 18篇 |
1992年 | 44篇 |
1991年 | 44篇 |
1990年 | 34篇 |
1989年 | 33篇 |
1988年 | 31篇 |
1987年 | 18篇 |
1986年 | 16篇 |
1985年 | 20篇 |
1984年 | 27篇 |
1983年 | 21篇 |
1982年 | 10篇 |
1981年 | 12篇 |
1980年 | 14篇 |
1979年 | 16篇 |
1978年 | 8篇 |
1977年 | 6篇 |
1975年 | 6篇 |
1974年 | 8篇 |
1971年 | 6篇 |
排序方式: 共有5436条查询结果,搜索用时 15 毫秒
1.
2.
3.
Giuseppina Di Stefano Luigi Fiume Michele Baglioni Corrado Busi Pasquale Chieco Felix Kratz Alessandro Mattioli 《European journal of pharmaceutical sciences》2007,30(2):136-142
Several attempts have been made to enhance doxorubicin (DOXO) concentrations in tumour cells by drug conjugation with human albumin (HSA). HSA-DOXO has the drawback of causing DOXO accumulation in spleen and bone marrow, with a consequent leucopoenia not produced when lactose molecules are coupled to the carrier protein. In the present experiments we demonstrated that the effect of HSA lactosamination is not a consequence of a more rapid disappearance from the bloodstream of the lactosaminated conjugate (L-HSA-DOXO), which is rapidly internalized by the liver through the asialoglycoprotein receptor, but is due to a hindered uptake by spleen and bone marrow cells caused by the coupled lactose molecules. Experiments in vitro showed that HSA-DOXO produced an inhibition of murine macrophage proliferation not caused by L-HSA-DOXO. This result can be explained by higher amounts of the former conjugate entering in these cells and suggests macrophages as the cell type responsible for the spleen and bone marrow internalization of HSA-DOXO hindered by lactose coupling. Importantly, lactosamination of HSA did not reduce the marked uptake of HSA-DOXO by chemically induced rat hepatocellular carcinoma. L-HSA-DOXO, by avoiding DOXO accumulation in bone marrow is an attractive candidate for clinical trials against tumors which were found to actively internalize this conjugate in laboratory animals, such as hepatocellular carcinoma. 相似文献
4.
M Rengo V Terrinoni G Galati A De Cesare A Martinazzoli E Fiori M Borghese A Florio 《Minerva chirurgica》1990,45(7):469-476
Underlining the importance of Profundus Femoral Artery and its capacity to make up for lower limb's haemodynamics during obliterative arteriopathy, the Authors conceive a funnel-shaped intravascular prosthesis, Goretex constructed (PTFE), to introduce, in case of obstruction, in the artery lumen with a suitable instrument. The research is performed through ten oldster dogs whose average weight is twenty-four kilograms. Isolated the deep Femoral Artery and carried out an arteriotomy of about two centimetres on the Common Femoral Artery, we bring the prothesis in Profundis Femoral Artery and we fix it to the wall of the Common Femoral Artery with 8/O microsurgical dots. After thirty days, the arteriographic test shows the patency of the endoprosthesis with normal peripheral flow in nine animals out of ten. By virtue of this preliminary experiment, the Authors point out the semplicity of this intervention, also feasible in local anaesthesia, the good tolerability of the prosthesis and its perfect integration with the surrounding arterious wall, without shifts or dissecting laminar flows between the external prosthesis wall and the vessel lumen of the animal. 相似文献
5.
Self-expanding mesh stent for endoscopic palliation of rectal obstructing tumors: a preliminary report 总被引:2,自引:0,他引:2
Summary The endoscopic insertion of self-expanding mesh stents in four patients affected by obstructing rectal malignant tumors is reported. The preliminary experience shows that, in the short term, normal defecation was achieved, with no complications. Longer follow-up is necessary to evaluate the duration and the quality of the palliative effect. 相似文献
6.
Demonstration of malignant cells in blood specimens collected during transurethral resection of the prostate (TURP) has implicated TURP in the dissemination of prostatic cancer. Of 153 patients who underwent radiation therapy for prostate cancer between January 1977 and June 1990 and were retrospectively analyzed, 93 were evaluable. Fifty-nine patients required TURP before radiation therapy for prostatic obstruction (BPH and/or cancer); the remaining 34 patients underwent radiation therapy after fine-needle aspiration biopsy. No statistically significant difference in failure rate could be detected between these groups, with a failure rate of 47% (28 of 59 patients) at a median follow-up time of 49 months (range, 8 to 146 months) in the TURP group versus a failure rate of 47% (16 of 34 patients) at a median follow-up time of 50 months (range, 3 to 122 months) in the group who underwent biopsy only (Fisher's exact test, P = 0.23). Within the confines of this retrospective study, it appeared that TURP did not enhance the development of metastatic disease. 相似文献
7.
Pasquale Mastroroberto Massimo Chello Francesco Onorati Attilio Renzulli 《European journal of cardio-thoracic surgery》2005,27(3):531-2; author reply 532
8.
9.
The aim of the present study was to investigate the existence of alterations of the blood-brain barrier (BBB) permeability in rats injected with centrally acting drugs, by calculating a unidirectional blood-to-brain transfer constant (Ki) for the circulating tracer [14C]-alpha-aminoisobutyric acid. The intraperitoneal (i.p.) injection of the dopaminergic antagonist haloperidol (1 mg kg-1) did not modify the regional BBB permeability. When the cholinomimetic agent arecoline hydrobromide (6.25 mg kg-1) was injected i.p. into methylatropine-pretreated rats, it induced a significant decrease of Ki values within the frontal cortex, parietal cortex, striatum and brain-stem. Our findings emphasize two concepts: (1) centrally acting drugs, such as arecoline, can induce changes in the BBB permeability, through several mechanisms; (2) there is no predictable correlation of drug stimulation of specific brain neuronal pathways and changes in the permeability of the BBB. 相似文献
10.