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Ketai LH; Williamson MR; Telepak RJ; Levy H; Koster FT; Nolte KB; Allen SE 《Radiology》1994,191(3):665
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S. van Ruth† EBL van Dorst‡ MR Canninga-van Dijk§ MS de Bruin-Weller† 《Journal of the European Academy of Dermatology and Venereology》2007,21(5):678-680
Cutaneous metastasis of vaginal carcinoma is extremely rare. So far, the total number of reported skin metastasis of vaginal carcinoma is only one. We present another case with an unusual manifestation of vagina carcinoma metastasis: skin metastasis presenting as a leg ulcer on the lower leg. 相似文献
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Breast cancer micrometastases: Different interactions of carcinoma cells with normal and cancer patients' bone marrow stromata 总被引:6,自引:1,他引:6
Nicola MH Bizon R Machado JJ Sollero T Rodarte RS Nobre JS Magalhães MM Takiya CM Borojevic R 《Clinical & experimental metastasis》2003,20(5):471-479
The apparently dormant breast cancer micrometastases in haemopoietic marrow are correlated with distant metastatic carcinoma
dissemination. We studied in vitro interactions of carcinoma cells with adjacent stromata, using connective tissue cell cultures from breast and bone marrow
samples of normal donors, comparing them to the pericancerous breast tissue and bone marrows of 12 selected patients with
invasive breast carcinomas. Cancer cells were detected by immunocytochemistry and RT-PCR in all the bone marrows and in most
blood samples of the studied patients. We monitored the growth and interaction of carcinoma MCF-7 cells with the stromata.
The normal breast stroma sustained typical massive cancer growth. The pericancerous breast stroma induced the invasive mesenchymal
pattern of growth. Normal bone marrow stroma induced the same conversion and was highly adhesive, retaining the cells in the
stroma, but carcinoma patients' bone marrow stromata underwent low adhesive interactions with cancer cells, releasing them
potentially into the circulation. The semi-quantitative RT-PCR indicated an enhanced expression of the hepatocyte growth factor
and its receptor c-met in breast and bone marrow stromata of cancer patients. The input of cancer cells into the normal bone marrow may induce modifications
of the local microenvironment, favourable for growth and release of carcinoma cells into the systemic circulation, which correlate
with the poor prognosis of patients with bone marrow micrometastases.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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Localization of a gene for otosclerosis to chromosome 15q25-q26 总被引:5,自引:0,他引:5
Tomek MS; Brown MR; Mani SR; Ramesh A; Srisailapathy CR; Coucke P; Zbar RI; Bell AM; McGuirt WT; Fukushima K; Willems PJ; Van Camp G; Smith RJ 《Human molecular genetics》1998,7(2):285-290
Among white adults otosclerosis is the single most common cause of hearing
impairment. Although the genetics of this disease are controversial, the
majority of studies indicate autosomal dominant inheritance with reduced
penetrance. We studied a large multi- generational family in which
otosclerosis has been inherited in an autosomal dominant pattern. Five of16
affected persons have surgically confirmed otosclerosis; the remaining nine
have a conductive hearing loss but have not undergone corrective surgery.
To locate the disease- causing gene we completed genetic linkage analysis
using short tandem repeat polymorphisms (STRPs) distributed over the entire
genome. Multipoint linkage analysis showed that only one genomic region, on
chromosome 15q, generated a lod score >2.0. Additional STRPs were typed
in this area, resulting in a lod score of 3.4. STRPs FES (centromeric) and
D15S657 (telomeric) flank the 14. 5 cM region that contains an otosclerosis
gene.
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