全文获取类型
收费全文 | 50篇 |
免费 | 1篇 |
专业分类
儿科学 | 1篇 |
妇产科学 | 1篇 |
基础医学 | 1篇 |
临床医学 | 8篇 |
内科学 | 18篇 |
神经病学 | 3篇 |
特种医学 | 8篇 |
外科学 | 4篇 |
预防医学 | 1篇 |
药学 | 4篇 |
肿瘤学 | 2篇 |
出版年
2023年 | 1篇 |
2021年 | 1篇 |
2020年 | 3篇 |
2019年 | 2篇 |
2018年 | 3篇 |
2016年 | 1篇 |
2015年 | 1篇 |
2014年 | 1篇 |
2013年 | 3篇 |
2012年 | 3篇 |
2011年 | 1篇 |
2010年 | 2篇 |
2009年 | 4篇 |
2008年 | 6篇 |
2007年 | 2篇 |
2006年 | 2篇 |
2005年 | 3篇 |
2004年 | 4篇 |
2003年 | 2篇 |
2001年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
排序方式: 共有51条查询结果,搜索用时 46 毫秒
1.
Oguzhan Deyneli İhsan Nuri Akpınar Özlem Sezgin Meriçliler Hülya Gözü Mehmet Erdem Yıldız Nefise Sema Akalın 《Annales d'endocrinologie》2014
Objectives
Contradictory results are encountered in literature regarding the effects of hypothyroidism on the risk factors of atherosclerosis. We aimed to explore the changes in atherosclerotic risk factors and insulin sensitivity before and after levothyroxine replacement therapy in women with primary hypothyroidism and compare with that of healthy controls.Patients and methods
Twelve patients (mean age of 34 ± 11.7 years) without an evident disease except for primary hypothyroidism (TSH ≥ 20 mIU/L) and eleven euthyroid, age-matched (33.8 ± 8.4 years) female volunteers as controls were included. Baseline thyroid hormones, lipid parameters, homocysteine, fibrinogen levels were measured in both groups. Flow-mediated endothelial-dependent vasodilatation (FMD) method was used to evaluate endothelial dysfunction. Insulin sensitivity was assessed by M values based on euglycemic hyperinsulinemic clamp technique. The same measurements were performed after 6 months of levothyroxine treatment and recovery of euthyroid state in hypothyroid patients.Results
Treatment reduced total cholesterol (P < 0.005), LDL-cholesterol (P < 0.005), lipoprotein(a) (P < 0.01), fibrinogen (P < 0.0001) and homocysteine (P < 0.0005) levels. Treatment significantly improved M values of hypothyroid patients (3.68 ± 1.53 mg/kg.min vs 6.02 ± 1.21 mg/kg.min, P < 0.0001) and FMD (9.1 ± 3.7% vs 16.4 ± 4.4%, hypothyroid vs euthyroid, P < 0.0001). Significant correlations were found between M values and TSH (r = −0.6, P < 0.005), fibrinogen (r = −0.53, P < 0.01) measurements, free T3 (r = 0.51, P < 0.02) and free T4 (r = 0.49, P < 0.02) levels. FMD was significantly correlated with fibrinogen levels (r = −0.49, P < 0.05).Conclusion
Insulin resistance, endothelial dysfunction, atherosclerotic risk markers improves with treatment of hypothyroidism. 相似文献2.
Meniscal tears: role of axial MRI alone and in combination with other imaging planes 总被引:2,自引:0,他引:2
Tarhan NC Chung CB Mohana-Borges AV Hughes T Resnick D 《AJR. American journal of roentgenology》2004,183(1):9-15
OBJECTIVE: The purpose of this study was to determine the reliability of standard axial MR images alone in the diagnosis of meniscal tears of the knee and in combination with other imaging planes. MATERIALS AND METHODS: Sixty-two patients (55 men, seven women; age range, 23-68 years) with a prior MRI examination who underwent arthroscopic surgery of the knee during a 1-year period were included in the study group. Images were independently reviewed for identification of meniscal tears by two musculoskeletal radiologists blinded to arthroscopic findings. Sequences for meniscal evaluation included axial fat-saturated fast spin-echo proton density, coronal fat-saturated fast spin-echo proton density, and sagittal fast spin-echo proton density with 4- to 5-mm slice thicknesses. Imaging groups for evaluation were axial, coronal, sagittal, axial and sagittal, axial and coronal, and coronal and sagittal. Observers reported a confidence level for the presence or absence of meniscal tear in all imaging groups based on a 5-point scale. Statistical analysis considered medial and lateral menisci separately. RESULTS: Forty patients had medial meniscal tears, and 16 had lateral meniscal tears at arthroscopy. For medial and lateral meniscal tears, the accuracy (79% and 71%, respectively) of imaging in the axial plane was comparable to other imaging groups but the mean confidence levels (2.82 and 3.00, respectively) were low. In one patient, the axial plane alone correctly showed that no tear was present. No statistically significant difference was observed between imaging plane groups of both menisci in the diagnosis of meniscal tears (p > 0.05). The axial plane increased the accuracy of sagittal and coronal planes of lateral meniscus when combined. CONCLUSION: In standard knee MRI examinations, the axial imaging plane may be valuable for the detection and characterization of meniscal tears. 相似文献
3.
Aydemir H Oztoprak N Celebi G Altinyazar C Barut F Piskin N Akduman D 《Internal medicine (Tokyo, Japan)》2008,47(16):1481-1484
Sweet's syndrome is a multisystem inflammatory disorder characterized by painful, erythematous plaques and aseptic neutrophilic infiltration of various organs. The absence of vasculitis is a histological criterion for diagnosis, but recent reports suggest that vasculitis can occur in Sweet's syndrome. Involvement of the central nervous system and the pulmonary system is very rare. In this case study we describe a chronic alcoholic man with Sweet's syndrome associated with acute-onset encephalitis and severe pulmonary involvement. The patient's symptoms responded dramatically to steroid treatment, and notably, a skin biopsy of his lesions showed vasculitis. 相似文献
4.
Huseyin Demirors Esra Circi Rahmi Can Akgun Nefise Cagla Tarhan Nuri Cetin Sercan Akpinar Ismail Cengiz Tuncay 《International orthopaedics》2010,34(4):531-536
The aim of this study was to investigate the correlation of tendon integrity following open cuff repairs with functional and
isokinetic strength measurements. Twenty-six shoulders of 25 patients were included in this study. At the final follow-up,
14 repairs (53.8%) were intact and 12 repairs (46.2%) had failed on magnetic resonance imaging (MRI). Mean UCLA score at latest
follow-up was 28.5 and mean Constant score was 80.3. Constant scores were found to be significantly low for the failed group.
Age was found to be significantly related to failed repair. Fatty infiltration stage in the failed repair group was significantly
high, and a strong positive correlation for both groups existed pre and postoperatively. When both groups were compared, the
failed group was found to have significantly low measurements at extension and internal rotation. Despite high failure rates,
functional results were satisfactory. Increased age and fatty infiltration stage decrease success. 相似文献
5.
6.
Adnan?GiralEmail author Kemal?Memi?o?lu Yücel?Gültekin Ne?e??meryüz Cem?Kalayc? Nefise?B?Ulusoy Nurdan?T?zün 《BMC gastroenterology》2004,4(1):7
Background
Although lateral internal sphincterotomy is the gold-standard treatment for chronic anal fissure, intrasphincteric injection of botulinum toxin seems to be a reliable new option. The aim of this non-randomized study is to compare the effect of lateral internal sphincterotomy and botulinum toxin injection treatments on the outcome and reduction of anal sphincter pressures in patients with chronic anal fissure.Methods
Patients with chronic anal fissure were treated with either botulinum toxin injection or lateral internal sphincterotomy by their own choice. Maximal resting pressure and maximal squeeze pressure measurements were performed before and 2 weeks after treatments by anal manometry. Patients were followed for fissure relapse during 14 months.Results
Twenty-one consecutive outpatients with posterior chronic anal fissure were enrolled. Eleven patients underwent surgery and ten patients received botulinum toxin injection treatment. Before the treatment, anal pressures were found to be similar in both groups. After the treatment, the maximal resting pressures were reduced from 104 ± 22 mmHg to 86 ± 15 mmHg in the surgery group (p < 0.05) and from 101 ± 23 mmHg to 83 ± 24 mmHg in the botulinum toxin group (p < 0.05). The mean maximal squeeze pressures were reduced from 70 ± 27 mmHg to 61 ± 32 mmHg (p > 0.05) in the surgery group, and from 117 ± 62 mmHg to 76 ± 34 (p < 0.01) in the botulinum toxin group. The fissures were healed in 70 percent of patients in the botulinum group and 82 percent in the surgery group (p > 0.05). There were no relapses during the 14 months of follow up.Conclusion
Lateral internal sphincterotomy and botulinum toxin injection treatments both seem to be equally effective in the treatment of chronic anal fissure.7.
Hakan Erdem Hulya Turkan Aykut Cilli Ahmet Karakas Zuhal Karakurt Uğur Bilge Ozlem Yazicioglu-Mocin Nazif Elaldi Nalan Adıguzel Gokay Gungor Canturk Taşcı Gulden Yilmaz Oral Oncul Aygul Dogan-Celik Ozcan Erdemli Nefise Oztoprak Yakup Tomak Asuman Inan Levent Gorenek 《International journal of infectious diseases》2013,17(9):e768-e772
8.
Buket Bakan Fatih Oltulu Yeliz Y?ld?r?m Altu? Yava?o?lu Sinan Akg?l Nefise ülkü Karabay Yava?o?lu 《Arhiv za higijenu rada i toksikologiju》2023,74(3):207
The aim of this safety study in mice was to determine in vivo toxicity and biodistribution potential of a single and multiple doses of L-glutamic acid-g-p(HEMA) polymeric nanoparticles as a drug delivery system. The single dose did not cause any lethal effect, and its acute oral LD50 was >2.000 mg/kg body weight (bw). Multiple doses (25, 50, or 100 mg/kg bw) given over 28 days resulted in no significant differences in body and relative organ weights compared to control. These results are supported by biochemical and histological findings. Moreover, nanoparticle exposure did not result in statistically significant differences in micronucleus counts in bone marrow cells compared to control. Nanoparticle distribution was time-dependent, and they reached the organs and even bone marrow by hour 6, as established by ex vivo imaging with the IVIS® spectrum imaging system. In conclusion, L-glutamic acid-g-p(HEMA) polymeric nanoparticles appear biocompatible and have a potential use as a drug delivery system.KEY WORDS: biocompatibility, blood biochemistry, genotoxicity, histology, in vivo toxicity, micronucleus test, polymers 相似文献
9.
Some of appropriate aminoisopropanoloxy derivatives of 4-xanthone were tested for their effect on circulatory system (protection against adrenaline-, barium-, and calcium chloride-induced arrhythmias, as well as hypotensive activity and acute toxicity). The most prominent hypotensive activity was demonstrated by (+/-)-1-[4-(hydroxyethyl)-1-(piperazinyl)]-3-(4-xanthonoxy)-2-propanol dihydrochloride (II), which diminished arterial blood pressure by about 40% during one hour observation. The investigated compounds did not prevent adrenaline- and barium-induced arrhythmias. In calcium-induced model of arrhythmia compound II slightly intensified blocks (about 7%), but delayed extrasystoles (37%), efficiently prevented bigeminy (70%, p <0.01) and diminished (53%, p <0.05) mortality of animals. All investigated compounds decreased heart rate by 10 - 18%, prolonged P-Q section, QRS complex and Q-T interval. The most potent and significant negative chronotropic effect and markedly prolonged duration of P-Q section was demonstrated by compound II. The influence of investigated compounds on ECG components suggests that activity of compound IV is similar to class 1a anti-arrhythmic compounds according to Voughan-Williams classification of antiarrhythmic drugs, because of prolongation of P-Q and Q-T intervals and extension of QRS complex. Compounds II and IV were also evaluated for anticonvulsant activity in the maximal electroshock seizures (MES) and subcutaneous pentylenetetrazole seizure threshold (ScMet) assays and for neurotoxicity (TOX). The anti-MES activity in mice was found for IV, which in a dose of 100 mg/kg within 0.5 h after ip administration showed 75% anticonvulsant protection with 50% neurotoxicity. 相似文献
10.