全文获取类型
收费全文 | 156篇 |
免费 | 7篇 |
专业分类
儿科学 | 16篇 |
妇产科学 | 2篇 |
基础医学 | 55篇 |
临床医学 | 18篇 |
内科学 | 26篇 |
神经病学 | 4篇 |
特种医学 | 4篇 |
外科学 | 8篇 |
预防医学 | 10篇 |
眼科学 | 1篇 |
药学 | 2篇 |
肿瘤学 | 17篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 1篇 |
2020年 | 1篇 |
2019年 | 1篇 |
2017年 | 2篇 |
2016年 | 3篇 |
2015年 | 3篇 |
2014年 | 5篇 |
2013年 | 9篇 |
2012年 | 13篇 |
2011年 | 14篇 |
2010年 | 10篇 |
2009年 | 14篇 |
2008年 | 15篇 |
2007年 | 6篇 |
2006年 | 11篇 |
2005年 | 10篇 |
2004年 | 4篇 |
2003年 | 5篇 |
2002年 | 7篇 |
2001年 | 5篇 |
2000年 | 3篇 |
1999年 | 5篇 |
1998年 | 2篇 |
1996年 | 1篇 |
1989年 | 3篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1942年 | 1篇 |
1922年 | 2篇 |
1920年 | 1篇 |
1919年 | 1篇 |
排序方式: 共有163条查询结果,搜索用时 296 毫秒
1.
2.
3.
4.
M J van den Bent M J B Taphoorn A A Brandes J Menten R Stupp M Frenay O Chinot J M Kros C C D van der Rijt Ch J Vecht A Allgeier T Gorlia 《Journal of clinical oncology》2003,21(13):2525-2528
PURPOSE: Oligodendroglial tumors are chemotherapy-sensitive tumors, with two thirds of patients responding to combination chemotherapy with procarbazine, lomustine, and vincristine (PCV). Temozolomide (TMZ), a new alkylating and methylating agent, has demonstrated high response rates in patients with recurrent anaplastic astrocytoma. We investigated TMZ as first-line chemotherapy in recurrent oligodendroglial tumors (OD) and mixed oligoastrocytomas (OA) after surgery and radiation therapy. PATIENTS AND METHODS: In a prospective, nonrandomized, multicenter, phase II trial, patients were treated with 200 mg/m2 of TMZ on days 1 through 5 in 28-day cycles for 12 cycles. Patients with a recurrence after prior surgery and radiotherapy, and with measurable and enhancing disease on magnetic resonance imaging (MRI) were eligible for this study. Patients with large lesions and mass effect or with new clinical deficits were not eligible. Pathology and the MRI scans of all responding patients were centrally reviewed. RESULTS: Thirty-eight eligible patients were included. In three patients, pathology review did not confirm the presence of an OD or OA. TMZ was generally well tolerated. The most frequent side effects were hematologic; only one patient discontinued treatment for toxicity. In 20 (52.6%) of 38 patients (95% exact confidence interval, 35.8% to 69.0%), a complete (n = 10) or partial response to TMZ was observed. The median time to progression was 10.4 months for all patients and 13.2 months for responding patients. At 12 months from the start of treatment, 40% of patients were still free from progression. CONCLUSION: TMZ provides an excellent response rate with good tolerability in chemotherapy-naive patients with recurrent OD. A randomized phase III study comparing PCV with TMZ is warranted. 相似文献
5.
Genomic aberrations of the CACNA2D1 gene in three patients with epilepsy and intellectual disability
Sarah Vergult Annelies Dheedene Alfred Meurs Fran Faes Bertrand Isidor Sandra Janssens Agnès Gautier Cédric Le Caignec Bj?rn Menten 《European journal of human genetics : EJHG》2015,23(5):628-632
Voltage-gated calcium channels have an important role in neurotransmission. Aberrations affecting genes encoding the alpha subunit of these channels have been associated with epilepsy and neuropsychiatric disorders such as autism or schizophrenia. Here we report three patients with a genomic aberration affecting the CACNA2D1 gene encoding the α2δ subunit of these voltage-gated calcium channels. All three patients present with epilepsy and intellectual disability pinpointing the CACNA2D1 gene as an interesting candidate gene for these clinical features. Besides these characteristics, patient 2 also presents with obesity with hyperinsulinism, which is very likely to be caused by deletion of the CD36 gene. 相似文献
6.
Boulle A Hilderbrand K Menten J Coetzee D Ford N Matthys F Boelaert M Van der Stuyft P 《AIDS care》2008,20(7):771-781
The objective of this cross-sectional household survey was to assess factors influencing HIV risk perception, behaviour and intervention uptake in a community characterised by high HIV prevalence and availability of antiretroviral therapy (ART). The survey was conducted in Khayelitsha, South Africa and involved two-stage sampling with self-weighting clusters and random selection of households within clusters. One man and woman between 14 and 49 years old was interviewed in each household; 696 men and 879 women were interviewed for a response rate of 84% and 92% respectively. Ninety-three percent and 94% were sexually active with median age of sexual debut 15.3 and 16.5 years. Eighty-three percent and 82% reported a partner at the time of interview and 29% and 8% had additional partner(s). Forty-one percent and 33% reported condom use during the last sexual encounter. Thirty-seven percent of men not using condoms did not as they believed their partner to be faithful, whilst 27% of women did not as their partner refused. Twenty-eight percent and 53% had been tested for HIV. Having undergone HIV testing was not associated with condom usage, whilst current relationship status was the strongest association with condom usage for both men and women. In spite of a relatively high uptake of condoms and testing as well as ART availability, the HIV epidemic has continued unabated in Khayelitsha. Even greater coverage of preventive interventions is required, together with a national social and political environment that builds on the availability of both preventive and treatment services. 相似文献
7.
8.
9.
10.
Kristien Peeters PhD Paulius Palaima MSc Ana L. Pelayo‐Negro MD Antonio García MD Elena Gallardo MD Rosario García‐Barredo MD Ligia Mateiu MD PhD Jonathan Baets MD PhD Björn Menten PhD Els De Vriendt BSc Peter De Jonghe MD PhD Vincent Timmerman PhD Jon Infante MD PhD José Berciano MD PhD Albena Jordanova PhD 《Annals of neurology》2016,80(6):823-833