全文获取类型
收费全文 | 2310篇 |
免费 | 172篇 |
国内免费 | 105篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 65篇 |
妇产科学 | 82篇 |
基础医学 | 259篇 |
口腔科学 | 60篇 |
临床医学 | 245篇 |
内科学 | 446篇 |
皮肤病学 | 78篇 |
神经病学 | 107篇 |
特种医学 | 119篇 |
外国民族医学 | 1篇 |
外科学 | 478篇 |
综合类 | 50篇 |
预防医学 | 101篇 |
眼科学 | 87篇 |
药学 | 186篇 |
中国医学 | 4篇 |
肿瘤学 | 205篇 |
出版年
2022年 | 12篇 |
2021年 | 28篇 |
2020年 | 17篇 |
2019年 | 32篇 |
2018年 | 38篇 |
2017年 | 33篇 |
2016年 | 45篇 |
2015年 | 58篇 |
2014年 | 55篇 |
2013年 | 105篇 |
2012年 | 93篇 |
2011年 | 126篇 |
2010年 | 101篇 |
2009年 | 91篇 |
2008年 | 81篇 |
2007年 | 138篇 |
2006年 | 114篇 |
2005年 | 102篇 |
2004年 | 99篇 |
2003年 | 105篇 |
2002年 | 88篇 |
2001年 | 68篇 |
2000年 | 70篇 |
1999年 | 66篇 |
1998年 | 63篇 |
1997年 | 51篇 |
1996年 | 55篇 |
1995年 | 31篇 |
1994年 | 35篇 |
1993年 | 25篇 |
1992年 | 35篇 |
1991年 | 32篇 |
1990年 | 39篇 |
1989年 | 35篇 |
1988年 | 35篇 |
1987年 | 37篇 |
1986年 | 40篇 |
1985年 | 19篇 |
1984年 | 13篇 |
1983年 | 13篇 |
1982年 | 16篇 |
1981年 | 19篇 |
1980年 | 16篇 |
1979年 | 26篇 |
1978年 | 17篇 |
1977年 | 13篇 |
1976年 | 11篇 |
1974年 | 12篇 |
1972年 | 11篇 |
1966年 | 10篇 |
排序方式: 共有2587条查询结果,搜索用时 15 毫秒
1.
B. Davido R. Batista H. Fessi H. Michelon L. Escaut C. Lawrence M. Denis C. Perronne J. Salomon A. Dinh 《Médecine et maladies infectieuses》2019,49(3):214-218
Objective
A rapid and worrying emergence of vancomycin-resistant enterococci (VRE) gut colonization is occurring worldwide and may be responsible for outbreaks, especially in healthcare facilities. While no efficient decolonization strategies are recommended, we assessed fecal microbiota transplantation (FMT) to eradicate VRE colonization.Patients and method
Our main objective was to measure the impact of FMT on decolonization of VRE carriers, confirmed by at least two consecutive negative rectal swabs at one-week interval during a 3-month follow-up period. Patients received no antibiotic prior to the FMT.Results
After a month only three patients remained colonized with VRE. Decolonization was associated with 87.5% (n = 7) of success after three months as only one patient remained colonized.Conclusion
Our first results confirm that the FMT seems to be safe, with an impact on VRE colonization over time that may help control outbreaks. 相似文献2.
Nephronophthisis related to homozygous NPHP1 gene deletion as a cause of chronic renal failure in adults. 总被引:1,自引:0,他引:1
3.
Ophira Salomon Joseph Moisseiev Tamara Vilganski Rima Dardik Shimon Kurtz Eva Shpringer David M Steinberg Nurit Rosenberg 《Blood coagulation & fibrinolysis》2006,17(6):485-488
To determine whether polymorphisms of platelet surface glycoprotein associated with arterial thrombosis are risk factors for branch retinal vein occlusion. A case-control study in which 69 patients with branch retinal vein occlusion and 147 controls who attended the eye clinic for nonvascular complications participated. DNA was extracted from whole blood and analyzed for genotyping of platelet glycoprotein polymorphisms by polymerase chain reactions and specific restricted enzymes. No relationship was found between the four platelet glycoprotein polymorphisms i.e. GPIa C807T, VNTR and Kozak of glycoprotein Ibalpha, the HPA-1 of glycoprotein IIIa and the occurrence of branch retinal vein occlusion. The HPA-2 polymorphism was found in 18 out 60 (30%) patients with branch retinal vein occlusion in comparison with 27 out 142 (19%) of controls, with an estimated odds ratio of 1.8 (95% confidence interval, 0.91-3.65). The four platelet glycoprotein polymorphisms are not risk factors for branch retinal vein occlusion and therefore it seems unnecessary to screen those patients for it. A larger study is required, however, to determine whether HPA-2 is a novel risk factor for branch retinal vein occlusion. 相似文献
4.
CM Reid M. Nelson P. Beckinsale P. Ryan LMH Wing LJ Beilin MA Brown GLR Jennings CI Johnston J. Marley JJ McNeil TO Morgan J. Shaw ID Steven MJ West 《Clinical and experimental pharmacology & physiology》1997,24(5):370-373
1. The present study aimed to determine the feasibility of conducting a 5 year cardiovascular outcome trial of the treatment of 6000 elderly hypertensive patients in Australian general practices. 2. General practitioners (GPs) were invited to participate by mail and personal follow-up. Patient records were reviewed to identify subjects for a blood pressure (BP) screening programme. Blood pressure was measured on three occasions and eligible subjects were included if the average BP was 160 mmHg systolic or 90 mmHg diastolic if systolic BP was 140 mmHg. 3. Seven hundred and forty-one GPs were approached and 89 were enrolled in the study (12% of mail invites and 75% of those receiving a personal contact). In 16 practices where screening was completed, 82 000 records were reviewed to identify 4% patients eligible for screening. Twenty-two per cent of eligible subjects attended screening. Of 1938 subjects screened, 180 (9%) had BP 5=160/90 mmHg. Forty-seven percent of subjects (n = 916) were receiving antihypertensive therapy and 184 (20%) were withdrawn from therapy. One hundred and sixteen (63%) of these subjects had BP return to study entry levels within 6 weeks. Fifty-seven newly diagnosed and 81 previously treated subjects were randomized (7% of the screened population). 4. Based on the high participation rate of GPs, the response rate of patients to attend a BP screening programme and the 7% randomization to screening ratio for entry into the study, the ANBP2 pilot study has demonstrated that it is feasible to recruit subjects from Australian general practices to a cardiovascular outcome trial. 相似文献
5.
F Salomon R K?rprich J Biscoping J Strobel 《Klinische Monatsbl?tter für Augenheilkunde》1990,196(1):26-29
Local anesthetics injected retrobulbarly are detectable in the aqueous humor. From 40 patients who received a total dose of 140 mg lidocaine, 15 mg bupivacaine, and 30 mg etidocaine, samples of aqueous humor were taken between 30 and 90 minutes after administration (average 57 minutes). The mean lidocaine concentration was 1.02 micrograms/ml, that of bupivacaine 0.075 micrograms/ml. Etidocaine, used only for facial nerve block in front of the ear, could not be detected in the aqueous humor. All three substances were found in the central venous blood. It therefore appears unlikely that any of them are transported via the blood-aqueous barrier, whether actively or passively. Local anesthetics can inhibit corneal cell proliferation and result in lens opacification when administered into the conjunctival sac. It may be that local anesthetics detected in the aqueous humor have similar effects resulting from contact with the cornea and lens. 相似文献
6.
A Terenzi I Lubin T Lapidot O Salomon Y Faktorowich I Rabi M F Martelli Y Reisner 《Transplantation》1990,50(4):717-720
7.
Salomon Esquenazi 《Journal of ocular pharmacology and therapeutics》2007,23(6):567-570
PURPOSE: The aim of this study was to report a case of cystoid macular edema (CME) in a pseudophakic patient after switching from latanoprost to BAK-free travoprost. METHODS: This study is presented as an interventional case report. RESULTS: Clinical examination showed the development of CME, proven by ocular coherence tomography, after institution of BAK-free travoprost in a patient that was previously treated with Latanoprost. Ocular signs and symptoms responded to stopping travoprost and treatment with topical prednisolone and non-steroidal anti-inflammatory medicines. The intraocular pressure was successfully controlled with brimonidine tartrate 0.15%. CONCLUSIONS: CME is a known adverse effect of all prostaglandin analogs. However, our patient developed this complication after being switched from latanoprost to BAK-free travoprost. This may be due to exacerbation of a previously undiagnosed CME or to the ionic-buffered preservative system (sofZia) alone or in combination with travoprost unique to this product. It is prudent to exercise caution in the use of prostaglandin analogs and prostamides especially in high-risk eyes. 相似文献
8.
9.
Bone scintigraphy in tuberculous sacroiliitis 总被引:1,自引:0,他引:1
Radionuclide bone imaging is becoming increasingly important in the evaluation of musculoskeletal pain of uncertain cause. A case in which Tc-99m MDP bone imaging was employed to investigate complaints of low back pain is presented. Scan abnormalities directed clinicians towards appropriate further workup and diagnosis of unilateral tuberculous sacroiliitis. 相似文献
10.