全文获取类型
收费全文 | 141篇 |
免费 | 19篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 8篇 |
妇产科学 | 4篇 |
基础医学 | 24篇 |
口腔科学 | 7篇 |
临床医学 | 18篇 |
内科学 | 23篇 |
皮肤病学 | 2篇 |
神经病学 | 9篇 |
特种医学 | 5篇 |
外科学 | 11篇 |
综合类 | 3篇 |
预防医学 | 15篇 |
药学 | 15篇 |
中国医学 | 2篇 |
肿瘤学 | 9篇 |
出版年
2023年 | 1篇 |
2022年 | 9篇 |
2021年 | 8篇 |
2020年 | 12篇 |
2019年 | 7篇 |
2018年 | 13篇 |
2017年 | 5篇 |
2016年 | 10篇 |
2015年 | 7篇 |
2014年 | 11篇 |
2013年 | 16篇 |
2012年 | 15篇 |
2011年 | 12篇 |
2010年 | 5篇 |
2009年 | 4篇 |
2008年 | 6篇 |
2007年 | 3篇 |
2006年 | 3篇 |
2005年 | 5篇 |
2004年 | 3篇 |
2003年 | 3篇 |
2002年 | 2篇 |
1981年 | 1篇 |
排序方式: 共有161条查询结果,搜索用时 62 毫秒
1.
2.
Khadijeh Jamialahmadi Hamid Reza Sadeghnia Ghazaleh Mohammadi Ali Masoudi Kazemabad Mahmoud Hosseini 《Pathophysiology》2013,20(4):263-267
Introduction and objectiveBeneficial effects of glucosamine in spatial learning and memory impairment induced by scopolamine has been evaluated in rats by using Morris water maze.MethodsMale Wistar rats were randomly divided into control, scopolamine and scopolamine plus glucosamine groups. All injections were given in 5 consecutive days and 30 min after each injection, the rats were tested in the Morris water maze test. Escape latency and path length to reach the hidden platform were subjected to analysis of variance [ANOVA].ResultsThe rats treated with scopolamine showed increased escape latency and path length to reach the hidden platform compared to control group (P < 0.001). Both escape latency and traveled path length to reach the hidden platform in glucosamine treated animals (1 and 2 g/kg) were significantly lower (P < 0.05 to P < 0.001) than in the scopolamine group.ConclusionThe results of this study showed that the glucosamine can inhibit scopolamine-induced impairments of spatial learning and memory in rats. Glucosamine might offer a promise in either the prevention or the treatment of neurodegenerative diseases such as Alzheimer's disease. 相似文献
3.
Fatemeh Rahimi Khadijeh Kazemi Shahla Zahednejad Daniel López-López César Calvo-Lobo 《Journal of manipulative and physiological therapeutics》2018,41(6):503-507
Objective
The purpose of this study was to determine the prevalence of musculoskeletal disorders among Iranian physical therapists.Methods
A cross-sectional study was carried out. An online survey was completed by Iranian physiotherapists from June 2017 to August 2017. A total of 333 online questionnaires were sent, and 319 questionnaires were fully completed and used for data analysis. The Persian version of the Nordic Questionnaire was the main outcome measurement. This questionnaire identified work-related pain or discomfort in 9 parts of the body, including: (1) neck, (2) shoulder, (3) elbow, (4) wrists, (5) upper back, (6) lumbar, (7) thighs, (8) knee, and (9) ankle.Results
The findings of this study showed the prevalence of musculoskeletal disorders was 94% in Iranian physiotherapists. Lumbar (65%), neck (57.4%), shoulder (50.2%), upper back (49%), and knee (45.5%) were the most prevalent regions of these disorders. While ankle (19.7%) and elbow (21.6%) disorders showed the lowest prevalence.Conclusion
The prevalence of work-related musculoskeletal disorders was high in Iranian physiotherapists, especially in the lumbar, neck, shoulder, and upper back regions. 相似文献4.
[Purpose] The purpose of this study was to investigate the effect of aquatic exercises on
nonspecific low back pain (LBP) in elderly males. [Subjects and Methods] Thirty-two
elderly men aged 65 or older were recruited and randomly allocated to two groups: aquatic
training (3 d/wk for 12 wk) or a control group. Body mass index (BMI), percentage of body
fat (PBF), waist-hip ratio (WHR), and trunk muscle mass were measured before and after
training. [Results] The results suggested that all obesity variables including BMI, WHR,
and PBF of the aquatic training group were decreased significantly, while the trunk muscle
mass of the aquatic training group was increased significantly. Furthermore, low back pain
was decreased in the subjects after the intervention. [Conclusion] The water-based program
improved LBP and body composition in the elderly men.Key words: Elderly, Low back pain, Body composition 相似文献
5.
Safety,efficacy and pitfalls of fibrocyte application in the treatment of diabetic foot ulcer
下载免费PDF全文
![点击此处可从《International wound journal》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mohaddeseh Behjati Mohammad Hashemi Alireza Shoarayenejati Khadijeh Karbalaie Mohammad H Nasr‐Esfahani 《International wound journal》2015,12(1):27-31
Fibrocytes are unique bone marrow‐derived cells with great potential in wound healing. Hence, the aim of this study was to determine the safety and efficacy of the applied circulating fibrocytes in the treatment of non healing diabetic foot ulcers. Peripheral blood mononuclear cells were isolated by centrifugation through Ficoll–Paque method. After 3 days, the non adherent cells were removed by a single, gentle aspiration. Adherent cells were cultured in the same medium for 10 days. The cells were characterised using mouse anti‐human‐CD45‐fluorescein isothiocyanate (FITC) and mouse anti‐human–collagen I, and also characterised by immunofluorescence microscopy using the above mentioned antibodies. Sterility measures were applied for clinical evaluation. Based on the literature review, cell transplantation generally requires at least 3 × 106 cells regarding efficacy measures. As fibrocytes are non proliferating cells, 350 ml patient's blood is required to prepare patient‐specific serum before cell isolation and culture, and 85 ml patient's blood is needed for cell isolation and differentiation on cell transplantation applications. In our survey, no diabetic patient was inclined to be donor of such blood volume, mainly because of their pre‐assumption that they are anaemic. It is concluded that fibrocytes do not seem to be candidate cells for cell therapy in the treatment of diabetic foot ulcers because of the rarity of this cell population in circulation. 相似文献
6.
DeFelice ML Ruchelli ED Markowitz JE Strogatz M Reddy KP Kadivar K Mulberg AE Brown KA 《The American journal of gastroenterology》2003,98(8):1777-1782
OBJECTIVES: A relationship between autism and gastrointestinal (GI) immune dysregulation has been postulated based on incidence of GI complaints as well as macroscopically observed lymphonodular hyperplasia and microscopically determined enterocolitis in pediatric patients with autism. To evaluate GI immunity, we quantitatively assessed levels of proinflammatory cytokines, interleukin (IL)-6, IL-8, and IL-1beta, produced by intestinal biopsies of children with pervasive developmental disorders. METHODS: Fifteen patients, six with pervasive developmental disorders and nine age-matched controls, presenting for diagnostic colonoscopy were enrolled. Endoscopic biopsies were organ cultured, supernatants were harvested, and IL-6, IL-8, and IL-1beta levels were quantified by ELISA. Tissue histology was evaluated by blinded pathologists. RESULTS: Concentrations of IL-6 from intestinal organ culture supernatants of patients with pervasive developmental disorders (median 318.5 pg/ml, interquartile range 282.0-393.0 pg/ml) when compared with controls (median 436.9 pg/ml, interquartile range 312.6-602.5 pg/ml) were not significantly different (p = 0.0987). Concentrations of IL-8 (median 84,000 pg/ml, interquartile range 16,000-143,000 pg/ml) when compared with controls (median 177,000 pg/ml, interquartile range 114,000-244,000 pg/ml) were not significantly different (p = 0.0707). Concentrations of IL-1beta (median 0.0 pg/ml, interquartile range 0.0-94.7 pg/ml) when compared with controls (median 0.0 pg/ml, interquartile range 0.0-60.2 pg/ml) were not significantly different (p = 0.8826). Tissue histology was nonpathological for all patients. CONCLUSIONS: We have demonstrated no significant difference in production of IL-6, IL-8, and IL-1beta between patients with pervasive developmental disorders and age-matched controls. In general, intestinal levels of IL-6 and IL-8 were lower in patients with pervasive developmental disorders than in age-matched controls. These data fail to support an association between autism and GI inflammation. 相似文献
7.
Saeed Hajirezaee Hojatollah Jafaryan Samane Nazeri Khadijeh Shamekhi Ranjbar Hossein Khara Amin Golpour 《Comparative clinical pathology》2013,22(1):101-105
To investigate the role of sex steroids of the seminal fluid on sperm quality, the relationships between sex steroids and milt quality parameters (sperm motility and sperm production) were investigated in the Persian sturgeon. The seminal fluid levels of 17α,20β,21-trihydroxy-4-pregnen-3-one (20βs), and 11-ketotestosterone (11-KT) had positive relationships with sperm motility characteristics (percentage and duration of motility) and sperm density. Also, no relationships were found between other sex steroids including: Testosterone (T), progesterone (P), 17α-hydroxyprogesterone (OHP), and milt quality parameters. The good correlation of 20βs and 11-KT of the seminal fluid with sperm motility and sperm density suggests that these steroids may be important hormones involving in final maturation of the Persian sturgeon spermatozoa. 相似文献
8.
Adeleh Dehghani Nazhvani Reza Boostani Somayeh Afrasiabi Khadijeh Sadatnezhad 《Clinical neurology and neurosurgery》2013
Objectives
Children with Bipolar Mood Disorder (BMD) and those with Attention Deficit Hyperactivity Disorder (ADHD) share many clinical signs and symptoms; therefore, achieving an accurate diagnosis is still a challenge, especially in the first interview session. The main focus of this paper is to quantitatively classify the ADHD and BMD patients using their Visual Evoke Potential (VEP) features elicited from their Electroencephalogram (EEG) signals.Methods and materials
In this study, 36 subjects were participated including 12 healthy ones, 12 patients with ADHD and 12 ones with BMD. The age of ADHD patients was 16.92 ± 6.29 and for the BMD ones was 17.85 ± 3.68. Their scalp EEG signals in the presence of visual stimulus were recorded using 22 silver electrodes located according to the 10–20 international recording protocol. To extract their VEP, first a preprocessing step was executed to remove the power line and movement artifacts. Afterward, the wavelet denoising and synchronous averaging were applied to the preprocessed trials in order to elicit the P100 component. To obtain interpretable features from the evoked patterns, amplitude and latency were extracted and applied to the 1-Nearest Neighbor (1NN) classifier due to the locally scattered distribution of the VEP features.Results
The evaluation was performed according to leave-one(subject)-out method and the experimental results were led to 92.85% classification accuracy which is a fairly promising achievement to distinguish the BMD, ADHD, and healthy subjects from each other.Conclusion
From the physiological point of view, this result point out to the existence of significant difference in the neural activities of their visual system in the ADHD, BMD, and healthy subjects in response to a periodic optical stimulus. 相似文献9.
Fatemeh Gholami Sajjad Moradi Niloufar Rasaei Neda Soveid Leila Setayesh Khadijeh Mirzaei 《Journal of neurology》2022,269(1):205-216
Journal of Neurology - The Present study was conducted to systematically review the effect of the melatonin on sleep quality. We summarized evidence from randomized clinical trials (RCTs) that... 相似文献
10.
Samaneh Nakhaee Alireza Amirabadizadeh Jeffrey Brent Ebrahim Miri-Moghaddam Mohsen Foadoddini Khadijeh Farrokhfall 《Critical reviews in toxicology》2019,49(8):710-723
AbstractIntroduction: Tramadol is a synthetic opioid which is commonly used around the world to relieve moderate to severe pain. One of the serious possible complications of its use is seizures. The present study aims to investigate and summarize the studies related to tramadol and occurrences of seizures after tramadol use and factors influencing these seizures.Methodology: Our systematic review is compliant with PRISMA guidelines. Two researchers systematically searched PubMed/Medline, Web of Sciences, and Scopus. Cohort, case-control, cross-sectional studies, and clinical trials. The risk of bias was assessed using the Newcastle–Ottawa Scale After article quality assessment, a fixed or random model, as appropriate, was used to pool the results in a meta-analysis. Heterogeneity between the studies was assessed with using I-square and Q-test. Forest plots demonstrating the point and pooled estimates were drawn.Results: A total of 51 articles with total sample size of 101 770 patients were included. The results showed that seizure event rate in the subgroups of tramadol poisoning, therapeutic dosage of tramadol, and tramadol abusers was 38% (95% CI: 27–49%), 3% (95% CI: 2–3%), 37% (95% CI: 12–62%), respectively. Tramadol dose was significantly higher in the patients with seizures than those without (mean differences: 0.82, CI 95%: 0.17–1.46). The odds for occurrence of seizures were significantly associated with male gender (pooled OR: 2.24, CI 95%: 1.80–2.77). Naloxone administration was not associated to the occurrence of seizures (pooled OR: 0.47, 95% CI: 0.15–1.49).Conclusions: Our results demonstrate that the occurrence of seizures in patients exposed to tramadol are dose-dependent and related to male gender, but not related to naloxone administration. Given that, most of the evidence derives from studies utilizing a cross-sectional design, the association of tramadol with seizures should not be considered to be definitively established 相似文献