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NORIAKI SAKURAGI HITOSHI OHKUBO RITSU YAMAMOTO YOSHIHIRO SHIINA TOSHINOBU TANAKA KIHYOE ICHINOE SEIICHIRO FUJIMOTO 《BJOG : an international journal of obstetrics and gynaecology》1988,95(6):614-618
Summary. The ratio of serum pregnancy-specific β1 -glycoprotein (SP1) to the β-subunit of human chorionic gonadotrophin (β-hCG) before and after chemotherapy was measured in 12 patients with metastatic choriocarcinoma. The ratios before chemotherapy ranged between 0. 03 and 0. 75, with a mean value of 0. 34 (SD 0. 21). The ratio increased to over 1. 0 (1. 05–53. 3) after one or two courses of chemotherapy in seven of the 12 patients. These women achieved complete remission. In the other five patients who died of the disease due to drug resistance of the tumour, the ratio after chemotherapy was low (0. 04–0. 74) and tended to decline. These data suggest that the serum SPl/β-hCG ratio can be used to predict the prognosis of patients with choriocarcinoma. 相似文献
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