全文获取类型
收费全文 | 577篇 |
免费 | 33篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 37篇 |
妇产科学 | 5篇 |
基础医学 | 45篇 |
口腔科学 | 18篇 |
临床医学 | 40篇 |
内科学 | 142篇 |
皮肤病学 | 8篇 |
神经病学 | 18篇 |
特种医学 | 79篇 |
外科学 | 65篇 |
综合类 | 62篇 |
预防医学 | 40篇 |
眼科学 | 8篇 |
药学 | 25篇 |
肿瘤学 | 24篇 |
出版年
2023年 | 2篇 |
2022年 | 5篇 |
2021年 | 8篇 |
2020年 | 8篇 |
2019年 | 2篇 |
2018年 | 7篇 |
2017年 | 5篇 |
2016年 | 10篇 |
2015年 | 18篇 |
2014年 | 13篇 |
2013年 | 19篇 |
2012年 | 13篇 |
2011年 | 13篇 |
2010年 | 19篇 |
2009年 | 33篇 |
2008年 | 12篇 |
2007年 | 23篇 |
2006年 | 33篇 |
2005年 | 8篇 |
2004年 | 10篇 |
2003年 | 4篇 |
2002年 | 9篇 |
2001年 | 10篇 |
2000年 | 8篇 |
1999年 | 16篇 |
1998年 | 42篇 |
1997年 | 33篇 |
1996年 | 41篇 |
1995年 | 17篇 |
1994年 | 18篇 |
1993年 | 22篇 |
1992年 | 6篇 |
1991年 | 14篇 |
1990年 | 5篇 |
1989年 | 10篇 |
1988年 | 25篇 |
1987年 | 10篇 |
1986年 | 12篇 |
1985年 | 17篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1977年 | 3篇 |
1976年 | 5篇 |
1975年 | 3篇 |
1974年 | 1篇 |
1972年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有617条查询结果,搜索用时 785 毫秒
1.
2.
3.
4.
Marco Treskes Ulbe Holwerda Leo G. J. Nijtmans Herbert M. Pinedo Wim J. F. van der Vijgh 《Cancer chemotherapy and pharmacology》1992,29(6):467-470
Summary The reversibility of cisplatin-protein interactions by the modulating agent WR2721, its active thiol-metabolite WR1065, and the symmetrical disulfide WR33278 was studied using the model compounds (Pt(diethylenetriammine) monofunctionally bound to the sulfur in glutathione (Pt(dien)SG) and Pt(diethylenetriammine) monofunctionally bound to the sulfur in S-methylglutathione (Pt(dien)SMeG). Both model compounds could be quantified by high-performance liquid chromatography (HPLC) with UV detection. The Pt-cysteine-like bond in Pt(dien)SG could not be reversed by any of the WR compounds or by the strong nucleophiles thiosulfate (TS) and diethyldithiocarbamate (DDTC). However, the Ptmethionine-like bond in Pt(dien)SMeG could be reversed by WR1065, although the reversal was slow (k2=0.142m
–1 s–1) as compared with that obtained using the modulating agents TS (k2=10.1m
–1 s–1) and DDTC (k2=3.66m
–1 s–1). WR2721 was hardly able to reverse the Pt-S bond in Pt(dien)SMeG (k2=0.00529m
–1 s–1), and WR33278 showed no capacity to do so. The activity ofcis-diamminedichloroplatinum(II) (CDDP)-inactivated fumarase was not appreciably restored by any of the WR compounds (16%, 7.7%, and 0 for 20mm WR1065, WR2721, and WR33278, respectively) in contrast to the strong nucleophile DDTC (61% for 2mm DDTC). These in vitro studies provide information at the molecular level that may explain why WR2721, in contrast to DDTC, does not provide protection against cisplatin-induced nephrotoxicity when it is given after platinum-containing chemotherapy. The results support the present clinical use of WR2721 prior to the administration of platinum compounds.This study was financially supported by the Netherlands Cancer Fund (grant IKA 87-12) and by US Bioscience 相似文献
5.
6.
7.
8.
9.
Bals-Pratsch M; De Geyter C; Muller T; Frieling U; Lerchl A; Pirke KM; Hanker JP; Becker-Carus C; Nieschlag E 《Human reproduction (Oxford, England)》1997,12(5):896-904
Preliminary data have suggested that female infertility due to corpus
luteum insufficiency may be caused by subclinical hypothyroidism
[exaggerated thyroid-stimulating hormone (TSH) response to thyrotrophin-
releasing hormone (TRH) stimulation]. L-Thyroxine supplementation has been
recommended to achieve pregnancies in subclinical hypothyroid women. This
controlled study was carried out in order to investigate the biochemical
diagnosis of subclinical hypothyroidism as a possible infertility factor.
Five infertile patients (aged 25-36 years) with subclinical hypothyroidism
(n = 4, stimulated TSH >20 microU/ml) or primary hypothyroidism (n = 1)
and five healthy controls (aged 22-39 years) with normal thyroid function
(stimulated TSH <15 microU/ml), regular cycles and no history of
infertility were studied in the early follicular phase. In the pre-study
evaluation, eight of 23 volunteers (34.8%) had to be excluded because of
subclinical hypothyroidism with stimulated TSH values (TSHs) >15
microU/ml. Cycle function of patients and controls was compared by the
method of LH pulse pattern analysis. Therefore blood samples were drawn
every 10 min during a 24 h period. Sleep was recorded from midnight to 7
a.m. Repetition of the TRH tests at the end of the 24 h blood sampling
period confirmed the difference in stimulated TSH values of the two study
groups. Pulse analysis for luteinizing hormone (LH), TSH and prolactin
showed no differences between patients and controls for pulse frequency,
amplitude, height, length, area under curve (AUC) and the 24 h mean. Even
the hypothyroid patient had a normal LH pulse pattern. Additional
measurement of melatonin in pooled sera every 30 min gave the
well-documented diurnal profiles during day and night for both groups.
Patients had significantly higher melatonin values at seven time points
during the night. Peaks for LH, TSH, prolactin and cortisol were correlated
with the sleep stages wake, rapid eye movement, 1 + 2 and 3 + 4. We
concluded that corpus luteum insufficiency in female infertility cannot be
explained by subclinical hypothyroidism and thus should not be treated with
L-thyroxine for fertility reasons.
相似文献
10.