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排序方式: 共有63条查询结果,搜索用时 30 毫秒
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Dale L. Bailey Henryk Barthel Bettina Beuthin-Baumann Thomas Beyer Sotirios Bisdas Ronald Boellaard Johannes Czernin Alexander Drzezga Ulrike Ernemann Christiane Franzius Brigitte Gückel Rupert Handgretinger Markus Hartenbach Dirk Hellwig Helen Nadel Stephan G. Nekolla Thomas Pfluger Bernd J. Pichler Harald H. Quick Osama Sabri Bernhard Sattler Jürgen Schäfer Fritz Schick Barry A. Siegel Heinz P. Schlemmer Nina F. Schwenzer Jörg van den Hoff Patrick Veit-Haibach Hans F. Wehrl 《Molecular imaging and biology》2014,16(3):295-310
This workshop was held a year after the initial positron emission tomography/magnetic resonance (PET/MR) workshop in Tübingen, which was recently reported in this journal. The discussions at the 2013 workshop, however, differed substantially from those of the initial workshop, attesting to the progress of combined PET/MR as an innovative imaging modality. Discussions were focused on the search for truly novel, unique clinical and research applications as well as technical issues such as reliable and accurate approaches for attenuation and scatter correction of PET emission data. The workshop provided hands-on experience with PET and MR imaging. In addition, structured and moderated open discussion sessions, including six dialogue boards and two roundtable discussions, provided input from current and future PET/MR imaging users. This summary provides a snapshot of the current achievements and challenges for PET/MR. 相似文献
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Dose-Dependent Uptake of 3′-deoxy-3′-[18 F]Fluorothymidine by the Bowel after Total-Body Irradiation
Markus Hartenbach Andreas Delker Sabrina Hartenbach Juli Schlichtiger Sabrina Niedermoser Carmen Wängler Björn Wängler Guido Böning Franz Josef Gildehaus Klement Neumaier Kirsten Lauber Klaus Kraft Claus Belka Marcus Hacker Viktor Meineke Peter Bartenstein 《Molecular imaging and biology》2014,16(6):846-853
Purpose
The aim of this study is to non-invasively assess early, irradiation-induced normal tissue alterations via metabolic imaging with 3′-deoxy-3′-[18?F]fluorothymidine ([18?F]FLT).Procedures
Twenty-nine male C57BL/6 mice were investigated by [18?F]FLT positron emission tomography for 7 days after total body irradiation (1, 4, and 8 Gy) versus ‘sham’ irradiation (0 Gy). Target/background ratios were determined. The imaging results were validated by histology and immunohistochemistry (Thymidine kinase 1, Ki-67).Results
[18?F]FLT demonstrated a dose-dependent intestinal accumulation post irradiation. Mean target/background ratio (±standard error) 0 Gy: 1.4 (0.2), 1 Gy: 1.7 (0.1), 4 Gy: 3.1 (0.3), 8 Gy: 4.2 (0.6). Receiver operating characteristic analysis (area under the curve, p value): 0 vs. 1 Gy: 0.81, 0.049; 0 vs. 4 Gy: 1.0, 0.0016; and 0 vs. 8 Gy: 1.0, 0.0020. Immunohistochemistry confirmed the results.Conclusions
[18?F]FLT seems to provide dose-dependent information on radiation-induced proliferation in the bowel. This opens the perspective for monitoring therapy-related side-effects as well as assessing, e.g., radiation accident victims. 相似文献5.
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Fanconi H. Hamperl H. Ehrhart W. Lang H. Otto A. Hässig Ludwig Heilmeyer N. Matussek R. Marx R. Haas Talmage D. Ploog Strian W. Lang J. Eisenburg Lang Ludwig Heilmeyer H. Neubauer Walter Hartenbach A. Blumberg 《Journal of molecular medicine (Berlin, Germany)》1967,45(5):270-274
Ohne Zusammenfassung 相似文献
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Prof.Dr. W. Hartenbach 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1961,297(5):490-503
Ohne ZusammenfassungMit 12 Textabbildungen 相似文献
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W. Hartenbach 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1962,301(1):257-267
Ohne Zusammenfassung
Mit 10 Abbildungen 相似文献
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Venous thromboembolism prophylaxis: is two better than one? 总被引:1,自引:1,他引:0
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Kushner DM Connor JP Sanchez F Volk M Schink JC Bailey HH Harris LS Stewart SL Fine J Hartenbach EM;Wisconsin Oncology Network 《Gynecologic oncology》2007,105(2):358-364
OBJECTIVE: Results of the ICON4/AGO-OVAR-2.2 trial suggest that a platinum/taxane combination provides a survival benefit in relapsed, platinum-sensitive ovarian cancer compared to platinum alone. The optimal specific combination has yet to be determined. The current study evaluates weekly docetaxel and carboplatin in this setting. METHODS: Using a prospective phase II design, patients received weekly docetaxel (35 mg/m2) and carboplatin (AUC=2) administered days 1, 8, and 15 of a 28-day cycle. Initial treatment with a platinum-based regimen was required, with a treatment-free interval of at least 3 months. Patients could have received one prior regimen for recurrence. Biologically evaluable disease (CA-125) could be followed only if measurable disease was not present. Quality of life analysis utilized the FACT-O and FACT/GOG-Ntx scales. RESULTS: Thirty-six patients enrolled in the trial over 29 months. The majority had ovarian cancer (89%) and stage III/IV (97%) disease, with a median initial disease-free interval of 12 months. Most subjects were treated for first recurrence (81%) and had measurable disease (58%). The overall response rate was 67% (PR=52%, CR=15%), with 22% stable disease. Grade 3/4 neutropenia was common (48%) while serious anemia and thrombocytopenia were not. Neuropathy was generally mild and manageable. Carboplatin hypersensitivity led to 11 subjects coming off trial (31%). Diphenhydramine premedication produced a nonsignificant decrease in reaction rate. There was no detectable difference in quality of life due to therapy. CONCLUSION: The weekly regimen of carboplatin and docetaxel has a good response rate with an acceptable toxicity profile. 相似文献